CRCGN015_HEPG2_48H:C11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cimetidine 33.32 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN015_HEPG2_48H:C11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PLEKHJ1 pleckstrin homology domain containing, family J member 1 3.40397
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 3.2679
LASP1 LIM and SH3 protein 1 3.18643
WDR7 WD repeat domain 7 3.1721
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) 2.83415
CCDC86 coiled-coil domain containing 86 2.57838
PCGF2 polycomb group ring finger 2 2.57732
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 2.57017
CASC3 cancer susceptibility candidate 3 2.46891
ZNF280A zinc finger protein 280A 2.44412
FAM184A family with sequence similarity 184, member A 2.4096
AMT aminomethyltransferase 2.33218
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 2.29523
RNPS1 RNA binding protein S1, serine-rich domain 2.24977
MED24 mediator complex subunit 24 2.24458
CPED1 cadherin-like and PC-esterase domain containing 1 2.23786
GSK3A glycogen synthase kinase 3 alpha 2.22614
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa 2.18248
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) 2.17243
MRGBP MRG/MORF4L binding protein 2.16474
GSTM5 glutathione S-transferase mu 5 2.13177
NPTN neuroplastin 2.10861
TBXA2R thromboxane A2 receptor 2.10328
CAPNS1 calpain, small subunit 1 2.08969
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 2.0864
ATP5F1A ATP synthase F1 subunit alpha 2.07019
GSTA4 glutathione S-transferase alpha 4 2.06375
MRPL4 mitochondrial ribosomal protein L4 2.05439
NR0B2 nuclear receptor subfamily 0, group B, member 2 2.05114
LOC100533997 MAGEA10-MAGEA5 readthrough 2.03388
COPS4 COP9 signalosome subunit 4 2.02666
MOSPD3 motile sperm domain containing 3 2.00906
ARHGAP24 Rho GTPase activating protein 24 2.0026

decreased expression

Symbol Name Standardized Value
CXADR coxsackie virus and adenovirus receptor -5.73461
MRPS16 mitochondrial ribosomal protein S16 -4.18688
RECQL RecQ helicase-like -3.36925
PROM1 prominin 1 -3.00517
ERGIC2 ERGIC and golgi 2 -3.00506
DNM1L dynamin 1-like -2.9631
GOLT1B golgi transport 1B -2.80367
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.7812
TES testin LIM domain protein -2.70761
MT1X metallothionein 1X -2.42698
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.39239
CCDC91 coiled-coil domain containing 91 -2.37669
CSRP2 cysteine and glycine-rich protein 2 -2.36181
INTS13 integrator complex subunit 13 -2.34438
THBS4 thrombospondin 4 -2.24798
DPYSL2 dihydropyrimidinase-like 2 -2.22075
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -2.20616
JPT2 Jupiter microtubule associated homolog 2 -2.19349
BHLHE41 basic helix-loop-helix family, member e41 -2.12234
PLAAT3 phospholipase A and acyltransferase 3 -2.11538
TFPI2 tissue factor pathway inhibitor 2 -2.0558
TM9SF3 transmembrane 9 superfamily member 3 -2.04904
DERL1 derlin 1 -2.00206