CRCGN015_HEPG2_48H:D05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fm550 perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

65 genes differentially expressed following the CRCGN015_HEPG2_48H:D05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIMP2 TIMP metallopeptidase inhibitor 2 7.00852
ZNF586 zinc finger protein 586 5.51337
MSRA methionine sulfoxide reductase A 5.39407
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 5.2232
PHKA1 phosphorylase kinase, alpha 1 (muscle) 5.19037
C2CD2 C2 calcium-dependent domain containing 2 4.71944
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.19019
ABHD4 abhydrolase domain containing 4 3.8275
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.6735
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.30171
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.24278
CRELD2 cysteine-rich with EGF-like domains 2 2.86737
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 2.684
AXIN1 axin 1 2.64619
TSPAN1 tetraspanin 1 2.54262
KRTAP5-2 keratin associated protein 5-2 2.46918
ZNF134 zinc finger protein 134 2.43719
ZNF552 zinc finger protein 552 2.3776
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 2.34151
U2AF2 U2 small nuclear RNA auxiliary factor 2 2.3346
PGPEP1 pyroglutamyl-peptidase I 2.3097
GPR143 G protein-coupled receptor 143 2.30113
SLC75A1 solute carrier family 75 member 1 2.2973
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 2.2756
GSTK1 glutathione S-transferase kappa 1 2.2707
CXCR1 chemokine (C-X-C motif) receptor 1 2.25164
ARSF arylsulfatase F 2.21142
WDR4 WD repeat domain 4 2.19194
SPPL2A signal peptide peptidase like 2A 2.18341
TBC1D19 TBC1 domain family, member 19 2.17861
SLC45A2 solute carrier family 45, member 2 2.16067
REPIN1 replication initiator 1 2.14927
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 2.13961
RABL6 RAB, member RAS oncogene family-like 6 2.12866
GFRA3 GDNF family receptor alpha 3 2.12691
TATDN2 TatD DNase domain containing 2 2.10907
MEX3C mex-3 RNA binding family member C 2.10801
TRABD TraB domain containing 2.09684
NRBF2 nuclear receptor binding factor 2 2.07365
THOP1 thimet oligopeptidase 1 2.05395
PRRX1 paired related homeobox 1 2.05062
KCTD11 potassium channel tetramerization domain containing 11 2.04452

decreased expression

Symbol Name Standardized Value
ISOC1 isochorismatase domain containing 1 -7.84261
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -7.31994
COG7 component of oligomeric golgi complex 7 -3.81123
CXADR coxsackie virus and adenovirus receptor -3.62775
MT1X metallothionein 1X -3.56543
EIF5 eukaryotic translation initiation factor 5 -3.3193
TMEM97 transmembrane protein 97 -2.5912
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.56137
TUBB6 tubulin, beta 6 class V -2.3547
ATG4A autophagy related 4A, cysteine peptidase -2.35097
BMP4 bone morphogenetic protein 4 -2.34108
CPNE3 copine III -2.31747
COL4A5 collagen, type IV, alpha 5 -2.25389
AHR aryl hydrocarbon receptor -2.20924
MRTFB myocardin related transcription factor B -2.18379
CD2AP CD2-associated protein -2.18337
UBE2J1 ubiquitin-conjugating enzyme E2, J1 -2.11256
MARK3 MAP/microtubule affinity-regulating kinase 3 -2.0739
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 -2.05783
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -2.04062
ATF7IP2 activating transcription factor 7 interacting protein 2 -2.03297
FAM234B family with sequence similarity 234 member B -2.00795
SNAP29 synaptosomal-associated protein, 29kDa -2.00007