CRCGN015_HEPG2_48H:D06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fm550 perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

25 genes differentially expressed following the CRCGN015_HEPG2_48H:D06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 3.46577
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.00777
FFAR2 free fatty acid receptor 2 2.63115
CDC45 cell division cycle 45 2.44147
CASC3 cancer susceptibility candidate 3 2.32112
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 2.28731
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 2.2097
CXCR2 chemokine (C-X-C motif) receptor 2 2.16826
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.14584
POLR2M polymerase (RNA) II (DNA directed) polypeptide M 2.13381
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 2.08667
SLC75A1 solute carrier family 75 member 1 2.0668
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.05563

decreased expression

Symbol Name Standardized Value
MT1X metallothionein 1X -4.31739
LAP3 leucine aminopeptidase 3 -3.36693
S100P S100 calcium binding protein P -3.24524
SLC31A2 solute carrier family 31 (copper transporter), member 2 -2.71522
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.68938
TOR1A torsin family 1, member A (torsin A) -2.49474
VDAC1 voltage-dependent anion channel 1 -2.37056
CXADR coxsackie virus and adenovirus receptor -2.33639
TM9SF3 transmembrane 9 superfamily member 3 -2.18816
TEX10 testis expressed 10 -2.17378
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 -2.12454
SPHK1 sphingosine kinase 1 -2.08545