CRCGN015_HEPG2_48H:D20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description coumophos 32.42 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

21 genes differentially expressed following the CRCGN015_HEPG2_48H:D20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.09132
DENND2D DENN/MADD domain containing 2D 2.81402
METRN meteorin, glial cell differentiation regulator 2.58068
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.51861
UBE2A ubiquitin-conjugating enzyme E2A 2.48134
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.37069
RPS5 ribosomal protein S5 2.35871
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 2.34896
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.29717
APOE apolipoprotein E 2.19849
AMDHD2 amidohydrolase domain containing 2 2.10655

decreased expression

Symbol Name Standardized Value
CXADR coxsackie virus and adenovirus receptor -7.9515
IL17RB interleukin 17 receptor B -3.23938
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.09129
PECR peroxisomal trans-2-enoyl-CoA reductase -3.05746
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -2.54783
HEATR1 HEAT repeat containing 1 -2.36138
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.32898
KLHL3 kelch-like family member 3 -2.16628
ZNF669 zinc finger protein 669 -2.12327
PTPN6 protein tyrosine phosphatase, non-receptor type 6 -2.01563