CRCGN015_HEPG2_48H:D22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n,n-dimethyl-n'-[3-(trifluoromethyl)phenyl]urea 96.55 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN015_HEPG2_48H:D22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 4.02233
ANO10 anoctamin 10 3.63852
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.31109
CNPY3 canopy FGF signaling regulator 3 3.09249
KIFBP kinesin family binding protein 3.0567
EPHB2 EPH receptor B2 2.91858
CALCOCO2 calcium binding and coiled-coil domain 2 2.42561
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.41122
SAP30L SAP30-like 2.39951
GPN3 GPN-loop GTPase 3 2.37747
RPS5 ribosomal protein S5 2.12727
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.08332
CHMP6 charged multivesicular body protein 6 2.0372
SMYD2 SET and MYND domain containing 2 2.03447
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 2.00395

decreased expression

Symbol Name Standardized Value
CXADR coxsackie virus and adenovirus receptor -7.00365
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -4.51234
LOC124907782 dual specificity protein phosphatase 22 -3.23381
MT1X metallothionein 1X -3.18436
S100P S100 calcium binding protein P -3.08968
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.81113
BIRC2 baculoviral IAP repeat containing 2 -2.62993
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -2.61438
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -2.60126
CRELD2 cysteine-rich with EGF-like domains 2 -2.53899
IGFBP7 insulin-like growth factor binding protein 7 -2.3953
RBM41 RNA binding motif protein 41 -2.38524
AP1S1 adaptor-related protein complex 1, sigma 1 subunit -2.33486
GASK1B golgi associated kinase 1B -2.2998
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 -2.28938
AFF4 AF4/FMR2 family, member 4 -2.27479
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -2.26797
NUSAP1 nucleolar and spindle associated protein 1 -2.25284
ND5 NADH dehydrogenase subunit 5 -2.24217
COG2 component of oligomeric golgi complex 2 -2.22977
ZNF665 zinc finger protein 665 -2.17692
KANSL3 KAT8 regulatory NSL complex subunit 3 -2.17599
ANXA5 annexin A5 -2.1384
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.13119
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.12262
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -2.11828
SOS2 son of sevenless homolog 2 (Drosophila) -2.10577
FCRLB Fc receptor-like B -2.09432
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 -2.08865
MAPK8 mitogen-activated protein kinase 8 -2.04654
NBPF10 neuroblastoma breakpoint family, member 10 -2.04588
PWWP3A PWWP domain containing 3A, DNA repair factor -2.03386
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -2.02467
NIPAL2 NIPA-like domain containing 2 -2.02169
TM9SF3 transmembrane 9 superfamily member 3 -2.01903
CD46 CD46 molecule, complement regulatory protein -2.01667