CRCGN015_HEPG2_48H:D24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n,n-dimethyl-n'-[3-(trifluoromethyl)phenyl]urea 10.73 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN015_HEPG2_48H:D24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 3.97283
LOC122526780 uncharacterized LOC122526780 3.35175
C2CD2 C2 calcium-dependent domain containing 2 3.33196
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 2.90399
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.82094
MAP7 microtubule-associated protein 7 2.71814
CYB561 cytochrome b561 2.47454
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.32921
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.28301
SNRPE small nuclear ribonucleoprotein polypeptide E 2.21781
CCNC cyclin C 2.14541
ZFP36 ZFP36 ring finger protein 2.11989
ETFA electron-transfer-flavoprotein, alpha polypeptide 2.1153
GRWD1 glutamate-rich WD repeat containing 1 2.11487
MRPL19 mitochondrial ribosomal protein L19 2.0833

decreased expression

Symbol Name Standardized Value
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -6.85298
S100P S100 calcium binding protein P -3.83291
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -3.38989
KIF20A kinesin family member 20A -3.15341
ATG4A autophagy related 4A, cysteine peptidase -2.81531
UFM1 ubiquitin-fold modifier 1 -2.6318
MT1X metallothionein 1X -2.60576
FAIM Fas apoptotic inhibitory molecule -2.44234
FBXO21 F-box protein 21 -2.42666
DTX4 deltex 4, E3 ubiquitin ligase -2.39659
EGFL6 EGF-like-domain, multiple 6 -2.32877
KCTD7 potassium channel tetramerization domain containing 7 -2.25799
GMPR2 guanosine monophosphate reductase 2 -2.23259
COL4A5 collagen, type IV, alpha 5 -2.21473
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.15107
PLAG1 pleiomorphic adenoma gene 1 -2.11739
MFAP1 microfibrillar-associated protein 1 -2.07055
ISLR immunoglobulin superfamily containing leucine-rich repeat -2.06555