CRCGN015_HEPG2_48H:E02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tin (ii) chloride 33.32 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN015_HEPG2_48H:E02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LAGE3 L antigen family, member 3 2.97634
PEX11A peroxisomal biogenesis factor 11 alpha 2.9582
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.94989
TLCD3A TLC domain containing 3A 2.87607
EXOSC4 exosome component 4 2.69356
SNX11 sorting nexin 11 2.59346
BAD BCL2-associated agonist of cell death 2.53547
MAP2K5 mitogen-activated protein kinase kinase 5 2.46882
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.43905
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 2.29013
PMM2 phosphomannomutase 2 2.24907
PENK proenkephalin 2.24068
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.18155
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.1645
NUCB2 nucleobindin 2 2.08664
CLSTN2 calsyntenin 2 2.04199
RNF139 ring finger protein 139 2.0349

decreased expression

Symbol Name Standardized Value
S100P S100 calcium binding protein P -5.54753
RHOB ras homolog family member B -4.28247
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -4.09836
ENOPH1 enolase-phosphatase 1 -3.94166
TM9SF3 transmembrane 9 superfamily member 3 -3.63744
DNM1L dynamin 1-like -3.62356
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.52935
ZDHHC6 zinc finger, DHHC-type containing 6 -3.42138
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -3.35076
PECR peroxisomal trans-2-enoyl-CoA reductase -3.13983
APOH apolipoprotein H (beta-2-glycoprotein I) -2.44846
APOA2 apolipoprotein A-II -2.36215
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 -2.25905
SCCPDH saccharopine dehydrogenase (putative) -2.24287
XPO7 exportin 7 -2.21675
NT5C2 5'-nucleotidase, cytosolic II -2.21203
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa -2.19544
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.17509
KCTD7 potassium channel tetramerization domain containing 7 -2.10607
TPPP tubulin polymerization promoting protein -2.10014
TF transferrin -2.07623
PADI1 peptidyl arginine deiminase, type I -2.00523