CRCGN015_HEPG2_48H:E10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-methylene-bis(2-methyl?aniline) 100.97 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

234 genes differentially expressed following the CRCGN015_HEPG2_48H:E10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BAX BCL2-associated X protein 4.86555
PRR15L proline rich 15-like 3.7625
HIKESHI heat shock protein nuclear import factor hikeshi 3.30375
FPGS folylpolyglutamate synthase 3.21
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 3.0995
TRIB3 tribbles pseudokinase 3 2.96025
VAT1 vesicle amine transport 1 2.95645
STOML2 stomatin (EPB72)-like 2 2.91425
TRIB1 tribbles pseudokinase 1 2.78965
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.78235
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.76965
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) 2.7338
DHRS4 dehydrogenase/reductase (SDR family) member 4 2.6895
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 2.68395
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.6767
PYCARD PYD and CARD domain containing 2.67565
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.6248
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) 2.604
SMIM5 small integral membrane protein 5 2.56983
IL32 interleukin 32 2.5667
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.536
PNPO pyridoxamine 5'-phosphate oxidase 2.5163
TMEM135 transmembrane protein 135 2.5126
GIPC2 GIPC PDZ domain containing family, member 2 2.43505
TPCN1 two pore segment channel 1 2.43385
TLCD3A TLC domain containing 3A 2.4187
TRIM15 tripartite motif containing 15 2.40665
GRAMD4 GRAM domain containing 4 2.3985
RIC8B RIC8 guanine nucleotide exchange factor B 2.3692
SQSTM1 sequestosome 1 2.3633
GPX2 glutathione peroxidase 2 2.3527
LACTB2 lactamase, beta 2 2.347
SLC67A1 solute carrier family 67 member 1 2.3315
DDIT4 DNA-damage-inducible transcript 4 2.30885
CARD9 caspase recruitment domain family, member 9 2.299
FES FES proto-oncogene, tyrosine kinase 2.2867
MTMR6 myotubularin related protein 6 2.28625
GK glycerol kinase 2.27318
YARS1 tyrosyl-tRNA synthetase 1 2.2695
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.2422
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.2312
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.2298
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like 2.22965
HKDC1 hexokinase domain containing 1 2.2244
CORO2A coronin, actin binding protein, 2A 2.2235
SPAG1 sperm associated antigen 1 2.2144
APOL6 apolipoprotein L, 6 2.20515
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 2.20183
NFE2L3 nuclear factor, erythroid 2-like 3 2.1891
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.1866
ZW10 zw10 kinetochore protein 2.1854
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) 2.17605
CERS6 ceramide synthase 6 2.1573
ATF4 activating transcription factor 4 2.15495
CHEK2 checkpoint kinase 2 2.14018
AEN apoptosis enhancing nuclease 2.1328
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 2.13115
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 2.10995
PCTP phosphatidylcholine transfer protein 2.1
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein 2.09965
TRIM37 tripartite motif containing 37 2.07825
NT5C 5', 3'-nucleotidase, cytosolic 2.07575
RAB11FIP1 RAB11 family interacting protein 1 (class I) 2.0603
AACS acetoacetyl-CoA synthetase 2.0538
SLC38A6 solute carrier family 38, member 6 2.0523
TXNRD1 thioredoxin reductase 1 2.05085
GATAD2A GATA zinc finger domain containing 2A 2.04515
TMEM147 transmembrane protein 147 2.03245
UBXN8 UBX domain protein 8 2.0299
HEATR3 HEAT repeat containing 3 2.02415
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 2.02338
PEPD peptidase D 2.01745
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 2.00467
GAB2 GRB2-associated binding protein 2 2.0004

decreased expression

Symbol Name Standardized Value
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -8.694
CALM2 calmodulin 2 (phosphorylase kinase, delta) -5.10075
GNAS GNAS complex locus -4.83546
HEATR1 HEAT repeat containing 1 -3.99255
MTERF3 mitochondrial transcription termination factor 3 -3.80285
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -3.67635
PABPC1 poly(A) binding protein, cytoplasmic 1 -3.4546
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -3.2304
SRSF4 serine/arginine-rich splicing factor 4 -3.13285
HMGN2 high mobility group nucleosomal binding domain 2 -2.9384
IKZF3 IKAROS family zinc finger 3 (Aiolos) -2.9211
KRT36 keratin 36, type I -2.866
CAPN6 calpain 6 -2.82585
TUBA1C tubulin, alpha 1c -2.81085
TUBA1B tubulin, alpha 1b -2.8006
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa -2.79365
RPLP2 ribosomal protein, large, P2 -2.7584
RPL19 ribosomal protein L19 -2.74495
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) -2.734
SRP9 signal recognition particle 9kDa -2.7118
STMN1 stathmin 1 -2.7018
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -2.67945
CSRP2 cysteine and glycine-rich protein 2 -2.678
NUP85 nucleoporin 85kDa -2.6559
ZNF148 zinc finger protein 148 -2.62138
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 -2.61713
TCL1A T-cell leukemia/lymphoma 1A -2.59293
CCNB1 cyclin B1 -2.57575
IL2 interleukin 2 -2.54805
RPL3 ribosomal protein L3 -2.54777
UBE2C ubiquitin-conjugating enzyme E2C -2.54105
RPL38 ribosomal protein L38 -2.53785
RCAN3 RCAN family member 3 -2.5365
TUBA1A tubulin, alpha 1a -2.51688
NCAM2 neural cell adhesion molecule 2 -2.5146
TLL1 tolloid-like 1 -2.50835
ZNF132 zinc finger protein 132 -2.49445
NCAPD2 non-SMC condensin I complex, subunit D2 -2.46765
BFSP2 beaded filament structural protein 2, phakinin -2.4485
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -2.4467
ZNF211 zinc finger protein 211 -2.4362
SELE selectin E -2.42125
ZNF350 zinc finger protein 350 -2.40945
NR2C2 nuclear receptor subfamily 2, group C, member 2 -2.4061
ENY2 enhancer of yellow 2 homolog (Drosophila) -2.401
ACTG1 actin gamma 1 -2.38007
MTSS2 MTSS I-BAR domain containing 2 -2.37405
ERGIC2 ERGIC and golgi 2 -2.3729
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 -2.36995
H2BC6 H2B clustered histone 6 -2.35445
NRTN neurturin -2.3478
MTMR10 myotubularin related protein 10 -2.33915
RPL27A ribosomal protein L27a -2.3327
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic -2.3287
CXADR coxsackie virus and adenovirus receptor -2.32835
CFHR5 complement factor H-related 5 -2.32315
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 -2.31855
CXCR5 chemokine (C-X-C motif) receptor 5 -2.31498
KLF12 Kruppel-like factor 12 -2.31288
MFAP1 microfibrillar-associated protein 1 -2.3123
PAGE4 P antigen family, member 4 (prostate associated) -2.3047
PTMA prothymosin, alpha -2.2876
SLC45A2 solute carrier family 45, member 2 -2.28338
HMGB1 high mobility group box 1 -2.26263
YBX1 Y box binding protein 1 -2.25713
NELFCD negative elongation factor complex member C/D -2.253
IGFBP7 insulin-like growth factor binding protein 7 -2.25075
SLC30A4 solute carrier family 30 (zinc transporter), member 4 -2.24835
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -2.2482
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 -2.24722
LEMD3 LEM domain containing 3 -2.24035
KIAA0040 KIAA0040 -2.2374
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -2.23265
POPDC2 popeye domain containing 2 -2.2319
PRELID3B PRELI domain containing 3B -2.22815
NRG2 neuregulin 2 -2.21905
H3-3A H3.3 histone A -2.2145
RIT2 Ras-like without CAAX 2 -2.21095
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 -2.20825
LEFTY1 left-right determination factor 1 -2.2059
MORF4L2 mortality factor 4 like 2 -2.2048
LOC100533997 MAGEA10-MAGEA5 readthrough -2.2026
EPHA5 EPH receptor A5 -2.20065
UBC ubiquitin C -2.19047
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -2.18633
MYT1L myelin transcription factor 1-like -2.1802
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -2.17665
LECT2 leukocyte cell-derived chemotaxin 2 -2.17655
NALF1 NALCN channel auxiliary factor 1 -2.17595
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.1727
GDF10 growth differentiation factor 10 -2.16745
SLBP stem-loop binding protein -2.1644
KMT2D lysine (K)-specific methyltransferase 2D -2.164
RPL4 ribosomal protein L4 -2.16285
COX6C cytochrome c oxidase subunit VIc -2.1619
ZXDA zinc finger, X-linked, duplicated A -2.14972
ZNF304 zinc finger protein 304 -2.14535
ZP2 zona pellucida glycoprotein 2 (sperm receptor) -2.1445
RPS11 ribosomal protein S11 -2.14435
RNF32 ring finger protein 32 -2.141
RIMS1 regulating synaptic membrane exocytosis 1 -2.14085
FGF14 fibroblast growth factor 14 -2.1394
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha -2.13855
CCKBR cholecystokinin B receptor -2.13815
PPIH peptidylprolyl isomerase H (cyclophilin H) -2.13765
STAP1 signal transducing adaptor family member 1 -2.1319
RORB RAR-related orphan receptor B -2.12695
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -2.1234
RPN2 ribophorin II -2.1233
ZFY zinc finger protein, Y-linked -2.1218
PUM1 pumilio RNA-binding family member 1 -2.1199
IP6K1 inositol hexakisphosphate kinase 1 -2.11865
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -2.0982
PRKD3 protein kinase D3 -2.09705
ORAI2 ORAI calcium release-activated calcium modulator 2 -2.09485
TACC3 transforming, acidic coiled-coil containing protein 3 -2.08515
SLIT2 slit homolog 2 (Drosophila) -2.08085
CCDC177 coiled-coil domain containing 177 -2.0794
UFD1 ubiquitin recognition factor in ER associated degradation 1 -2.07545
GJD3 gap junction protein, delta 3, 31.9kDa -2.07495
RPL30 ribosomal protein L30 -2.0738
HSPA1L heat shock 70kDa protein 1-like -2.07335
CD81 CD81 molecule -2.07225
RBMY1J RNA binding motif protein, Y-linked, family 1, member J -2.07165
EDDM3B epididymal protein 3B -2.06955
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -2.06955
RPS20 ribosomal protein S20 -2.06862
PPP1R3A protein phosphatase 1, regulatory subunit 3A -2.06745
UBXN2B UBX domain protein 2B -2.067
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 -2.0655
TUBA3E tubulin, alpha 3e -2.0643
EFNB2 ephrin-B2 -2.05655
GRM1 glutamate receptor, metabotropic 1 -2.05543
LATS1 large tumor suppressor kinase 1 -2.05425
KLHL11 kelch-like family member 11 -2.0521
GDF9 growth differentiation factor 9 -2.05145
ZNF37A zinc finger protein 37A -2.0494
FBXO34 F-box protein 34 -2.0492
TCEAL4 transcription elongation factor A (SII)-like 4 -2.04595
MTA2 metastasis associated 1 family, member 2 -2.0452
PBOV1 prostate and breast cancer overexpressed 1 -2.0451
TRPM1 transient receptor potential cation channel, subfamily M, member 1 -2.04205
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 -2.04135
SCN7A sodium channel, voltage gated, type VII alpha subunit -2.0396
SEC62 SEC62 homolog (S. cerevisiae) -2.0392
PLCB4 phospholipase C, beta 4 -2.034
ZNF334 zinc finger protein 334 -2.03375
TMA7 translation machinery associated 7 homolog (S. cerevisiae) -2.0326
ZNF324 zinc finger protein 324 -2.0316
CYB5R3 cytochrome b5 reductase 3 -2.03045
SLITRK3 SLIT and NTRK-like family, member 3 -2.02965
RPL36A ribosomal protein L36a -2.0253
ZNF287 zinc finger protein 287 -2.02425
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.0154
ZNF460 zinc finger protein 460 -2.01395
EEF2 eukaryotic translation elongation factor 2 -2.01375
ZNF432 zinc finger protein 432 -2.01305
CRISP1 cysteine-rich secretory protein 1 -2.01305
ADAM7 ADAM metallopeptidase domain 7 -2.01152
CDADC1 cytidine and dCMP deaminase domain containing 1 -2.01015