CRCGN015_HEPG2_48H:E17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description propyl gallate 33.49 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

318 genes differentially expressed following the CRCGN015_HEPG2_48H:E17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD4 abhydrolase domain containing 4 5.59088
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 4.75514
CHIC2 cysteine-rich hydrophobic domain 2 4.39424
MINDY1 MINDY lysine 48 deubiquitinase 1 4.33292
CDPF1 cysteine-rich, DPF motif domain containing 1 4.26476
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.01447
TXNRD1 thioredoxin reductase 1 4.00866
BLCAP bladder cancer associated protein 3.91712
ITFG1 integrin alpha FG-GAP repeat containing 1 3.8247
SQSTM1 sequestosome 1 3.75905
TRIB3 tribbles pseudokinase 3 3.74511
CTSL cathepsin L 3.60915
H2BC21 H2B clustered histone 21 3.56489
IGF2R insulin-like growth factor 2 receptor 3.32972
EMC7 ER membrane protein complex subunit 7 3.26443
AARS1 alanyl-tRNA synthetase 1 3.23555
LRP10 low density lipoprotein receptor-related protein 10 3.23298
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.16893
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.15729
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 3.02695
TERF2IP telomeric repeat binding factor 2, interacting protein 3.01813
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.98048
AKTIP AKT interacting protein 2.97918
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.95974
LOC128125814 uncharacterized LOC128125814 2.95607
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 2.93102
MAPK13 mitogen-activated protein kinase 13 2.91402
INPP1 inositol polyphosphate-1-phosphatase 2.86793
MICALL1 MICAL-like 1 2.84422
YARS1 tyrosyl-tRNA synthetase 1 2.81978
DDIT4 DNA-damage-inducible transcript 4 2.79893
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.79813
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 2.78103
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 2.71049
CCPG1 cell cycle progression 1 2.68457
RAP1GAP RAP1 GTPase activating protein 2.67257
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.65959
TMEM184B transmembrane protein 184B 2.63994
TMEM208 transmembrane protein 208 2.63014
TM2D1 TM2 domain containing 1 2.62094
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 2.60878
MAP7 microtubule-associated protein 7 2.58588
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.5762
TRIB1 tribbles pseudokinase 1 2.55978
ERMP1 endoplasmic reticulum metallopeptidase 1 2.51282
FCHO1 FCH domain only 1 2.5094
SLC67A1 solute carrier family 67 member 1 2.48679
NANOS3 nanos homolog 3 (Drosophila) 2.48297
DDB2 damage-specific DNA binding protein 2, 48kDa 2.48262
SARS1 seryl-tRNA synthetase 1 2.45963
GLRX glutaredoxin (thioltransferase) 2.44282
OSBPL2 oxysterol binding protein-like 2 2.43987
TMEM59 transmembrane protein 59 2.42973
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 2.42066
RAB5IF RAB5 interacting factor 2.41829
SPG11 spastic paraplegia 11 (autosomal recessive) 2.41519
CEPT1 choline/ethanolamine phosphotransferase 1 2.41339
BAZ2B bromodomain adjacent to zinc finger domain, 2B 2.41339
GPX2 glutathione peroxidase 2 2.39024
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 2.38107
CTSA cathepsin A 2.37753
NCOA1 nuclear receptor coactivator 1 2.37248
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.37193
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 2.36147
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.35892
ATG2A autophagy related 2A 2.35714
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 2.35199
KEAP1 kelch-like ECH-associated protein 1 2.3494
DDRGK1 DDRGK domain containing 1 2.34818
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.32817
IFRD1 interferon-related developmental regulator 1 2.31967
DERA deoxyribose-phosphate aldolase (putative) 2.31385
UBL3 ubiquitin-like 3 2.30575
CEMIP cell migration inducing protein, hyaluronan binding 2.29964
IL22RA1 interleukin 22 receptor, alpha 1 2.29627
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.29181
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 2.28426
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.27476
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.2696
OPLAH 5-oxoprolinase (ATP-hydrolysing) 2.26143
TSKU tsukushi, small leucine rich proteoglycan 2.25945
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.25524
SPATA20 spermatogenesis associated 20 2.24689
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 2.24384
CST7 cystatin F (leukocystatin) 2.24383
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 2.24093
NPC1 Niemann-Pick disease, type C1 2.22788
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.22557
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 2.22427
TMEM127 transmembrane protein 127 2.22407
NQO1 NAD(P)H dehydrogenase, quinone 1 2.19749
UBAP1 ubiquitin associated protein 1 2.18112
WHRN whirlin 2.17944
TOX3 TOX high mobility group box family member 3 2.1791
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.17667
LY96 lymphocyte antigen 96 2.17146
APOC1 apolipoprotein C-I 2.16781
AHCYL1 adenosylhomocysteinase-like 1 2.14836
TMEM106C transmembrane protein 106C 2.14033
CLCN3 chloride channel, voltage-sensitive 3 2.1371
HMOX1 heme oxygenase 1 2.13435
FERMT1 fermitin family member 1 2.1214
RNF43 ring finger protein 43 2.11171
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.10352
CISD1 CDGSH iron sulfur domain 1 2.10133
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 2.08397
ZFP36 ZFP36 ring finger protein 2.08218
RNF13 ring finger protein 13 2.08092
NPC2 Niemann-Pick disease, type C2 2.07042
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 2.06952
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 2.06291
RB1CC1 RB1-inducible coiled-coil 1 2.05816
PHGDH phosphoglycerate dehydrogenase 2.05809
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 2.05356
GARS1 glycyl-tRNA synthetase 1 2.05323
ATG9A autophagy related 9A 2.05296
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.04903
LAMA5 laminin, alpha 5 2.03473
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.02917
RETREG1 reticulophagy regulator 1 2.02817
CLCC1 chloride channel CLIC-like 1 2.01337
ACTR10 actin-related protein 10 homolog (S. cerevisiae) 2.00766
NARS1 asparaginyl-tRNA synthetase 1 2.00505

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -6.67147
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -4.93918
CDC20 cell division cycle 20 -4.4142
KIF20A kinesin family member 20A -4.34894
ERCC6L excision repair cross-complementation group 6-like -4.04354
BPHL biphenyl hydrolase-like (serine hydrolase) -3.9978
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.99241
CDCA3 cell division cycle associated 3 -3.63859
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.5709
NCK1 NCK adaptor protein 1 -3.44094
MCM3 minichromosome maintenance complex component 3 -3.37537
PLK1 polo-like kinase 1 -3.32975
KIFC1 kinesin family member C1 -3.32738
RPUSD2 RNA pseudouridylate synthase domain containing 2 -3.32335
BIRC5 baculoviral IAP repeat containing 5 -3.2958
NEK2 NIMA-related kinase 2 -3.28436
CCNB2 cyclin B2 -3.21187
UBE2C ubiquitin-conjugating enzyme E2C -3.15569
PIMREG PICALM interacting mitotic regulator -3.09322
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -3.09042
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -3.08171
AURKB aurora kinase B -2.99941
SNRPA small nuclear ribonucleoprotein polypeptide A -2.92755
MCM7 minichromosome maintenance complex component 7 -2.91708
KIF18A kinesin family member 18A -2.90233
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.89432
KIF4A kinesin family member 4A -2.89037
CENPE centromere protein E, 312kDa -2.88773
TPM1 tropomyosin 1 (alpha) -2.85396
CENPI centromere protein I -2.85288
LMNB1 lamin B1 -2.84164
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.79189
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.78063
H2AZ2 H2A.Z variant histone 2 -2.77323
CDCA8 cell division cycle associated 8 -2.76501
HJURP Holliday junction recognition protein -2.76183
CDC25C cell division cycle 25C -2.75905
NCAPD2 non-SMC condensin I complex, subunit D2 -2.75689
MCM10 minichromosome maintenance complex component 10 -2.74749
TRIP13 thyroid hormone receptor interactor 13 -2.74171
BTBD2 BTB (POZ) domain containing 2 -2.72638
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -2.71955
TUBA1B tubulin, alpha 1b -2.71636
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.70144
DEPDC1 DEP domain containing 1 -2.70008
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.66291
STMN1 stathmin 1 -2.65097
GJD3 gap junction protein, delta 3, 31.9kDa -2.64932
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.64764
CCNF cyclin F -2.64708
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 -2.62919
SPAG5 sperm associated antigen 5 -2.61609
RBMX RNA binding motif protein, X-linked -2.60623
SRSF2 serine/arginine-rich splicing factor 2 -2.60172
WRAP53 WD repeat containing, antisense to TP53 -2.58981
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -2.58489
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -2.58475
PARPBP PARP1 binding protein -2.58249
TUBA1A tubulin, alpha 1a -2.56968
KIF22 kinesin family member 22 -2.56931
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.55886
FEN1 flap structure-specific endonuclease 1 -2.54468
MYL9 myosin, light chain 9, regulatory -2.54251
GINS4 GINS complex subunit 4 (Sld5 homolog) -2.53894
ZNF287 zinc finger protein 287 -2.53127
TUBB4B tubulin, beta 4B class IVb -2.52506
INCENP inner centromere protein antigens 135/155kDa -2.51298
CCNA2 cyclin A2 -2.512
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) -2.51093
FLOT2 flotillin 2 -2.49217
KIF11 kinesin family member 11 -2.49085
PYCR3 pyrroline-5-carboxylate reductase 3 -2.48652
CHAF1A chromatin assembly factor 1, subunit A (p150) -2.47625
RFC2 replication factor C (activator 1) 2, 40kDa -2.45641
SQLE squalene epoxidase -2.45261
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.43545
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -2.42592
CDK2 cyclin-dependent kinase 2 -2.42521
TMEM97 transmembrane protein 97 -2.42079
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -2.41882
MSH6 mutS homolog 6 -2.40743
NGRN neugrin, neurite outgrowth associated -2.4058
TRMT5 tRNA methyltransferase 5 -2.40463
FBL fibrillarin -2.40202
TPX2 TPX2, microtubule-associated -2.39562
TUBA1C tubulin, alpha 1c -2.39529
HMGN2 high mobility group nucleosomal binding domain 2 -2.38779
CENPF centromere protein F, 350/400kDa -2.37568
TTK TTK protein kinase -2.36558
UBE2S ubiquitin-conjugating enzyme E2S -2.36414
OIP5 Opa interacting protein 5 -2.36079
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.34672
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -2.33535
KIF23 kinesin family member 23 -2.33292
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 -2.32575
NCAPD3 non-SMC condensin II complex, subunit D3 -2.32292
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A -2.32188
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.31581
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -2.31284
HSPA4 heat shock 70kDa protein 4 -2.3011
SDF2L1 stromal cell-derived factor 2-like 1 -2.28522
FAIM Fas apoptotic inhibitory molecule -2.28297
MKI67 marker of proliferation Ki-67 -2.27872
DCBLD2 discoidin, CUB and LCCL domain containing 2 -2.27568
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.27495
EID1 EP300 interacting inhibitor of differentiation 1 -2.2738
RUVBL1 RuvB-like AAA ATPase 1 -2.2723
HMGA2 high mobility group AT-hook 2 -2.27164
BORA bora, aurora kinase A activator -2.25987
HSPA8 heat shock 70kDa protein 8 -2.25495
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa -2.25458
ARHGAP11A Rho GTPase activating protein 11A -2.25378
KIF15 kinesin family member 15 -2.24818
SRP9 signal recognition particle 9kDa -2.24641
HMGB2 high mobility group box 2 -2.246
CALB1 calbindin 1, 28kDa -2.24557
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) -2.24382
SELE selectin E -2.23591
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -2.23479
TUBB2A tubulin, beta 2A class IIa -2.22054
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -2.21758
FOXM1 forkhead box M1 -2.20923
PPIH peptidylprolyl isomerase H (cyclophilin H) -2.20504
VRK1 vaccinia related kinase 1 -2.20278
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.20229
NUSAP1 nucleolar and spindle associated protein 1 -2.20158
PLK4 polo-like kinase 4 -2.19366
THAP11 THAP domain containing 11 -2.19332
PRPF4 pre-mRNA processing factor 4 -2.19207
TUBB tubulin, beta class I -2.18558
PDE5A phosphodiesterase 5A, cGMP-specific -2.18305
MCM4 minichromosome maintenance complex component 4 -2.16819
SRSF1 serine/arginine-rich splicing factor 1 -2.16259
QARS1 glutaminyl-tRNA synthetase 1 -2.16041
ZNF286A zinc finger protein 286A -2.15945
NUDC nudC nuclear distribution protein -2.15786
MYEF2 myelin expression factor 2 -2.15557
ILF2 interleukin enhancer binding factor 2 -2.1549
PYDC1 PYD (pyrin domain) containing 1 -2.15309
PRRX1 paired related homeobox 1 -2.15127
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) -2.15027
HMGB1 high mobility group box 1 -2.14862
DUT deoxyuridine triphosphatase -2.14739
SAMHD1 SAM domain and HD domain 1 -2.14736
CERT1 ceramide transporter 1 -2.14715
RUVBL2 RuvB-like AAA ATPase 2 -2.14421
TOP2A topoisomerase (DNA) II alpha 170kDa -2.14273
PLS1 plastin 1 -2.14078
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 -2.13835
NOCT nocturnin -2.13819
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor -2.13536
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.12597
TRDN triadin -2.12029
SLC26A4 solute carrier family 26 (anion exchanger), member 4 -2.12
TGFBR1 transforming growth factor, beta receptor 1 -2.11476
MCM5 minichromosome maintenance complex component 5 -2.11465
PDIA3 protein disulfide isomerase family A, member 3 -2.11424
RARS1 arginyl-tRNA synthetase 1 -2.11409
GPR176 G protein-coupled receptor 176 -2.11124
RFC3 replication factor C (activator 1) 3, 38kDa -2.10854
PLN phospholamban -2.10716
TM9SF3 transmembrane 9 superfamily member 3 -2.10666
SCN7A sodium channel, voltage gated, type VII alpha subunit -2.10517
WDR46 WD repeat domain 46 -2.10465
PAK1IP1 PAK1 interacting protein 1 -2.09977
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -2.08486
HTATSF1 HIV-1 Tat specific factor 1 -2.08431
SAFB scaffold attachment factor B -2.07818
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -2.07668
MNS1 meiosis-specific nuclear structural 1 -2.07663
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.07631
RAI1 retinoic acid induced 1 -2.07287
NDC80 NDC80 kinetochore complex component -2.07266
CLINT1 clathrin interactor 1 -2.06371
PGAM4 phosphoglycerate mutase family member 4 -2.05743
CCHCR1 coiled-coil alpha-helical rod protein 1 -2.057
ATG5 autophagy related 5 -2.05148
SLC39A7 solute carrier family 39 (zinc transporter), member 7 -2.04905
NOD2 nucleotide-binding oligomerization domain containing 2 -2.04846
GTSE1 G-2 and S-phase expressed 1 -2.04776
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.04501
TFPI2 tissue factor pathway inhibitor 2 -2.04403
PPP2R5D protein phosphatase 2, regulatory subunit B', delta -2.04356
PTTG1 pituitary tumor-transforming 1 -2.04119
NLRP2 NLR family, pyrin domain containing 2 -2.04025
TPI1 triosephosphate isomerase 1 -2.03658
HELLS helicase, lymphoid-specific -2.0288
VDAC1 voltage-dependent anion channel 1 -2.0236
ERC1 ELKS/RAB6-interacting/CAST family member 1 -2.02084
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 -2.01625
PSRC1 proline/serine-rich coiled-coil 1 -2.01468
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) -2.01164
MSH2 mutS homolog 2 -2.00957
CEP97 centrosomal protein 97kDa -2.00895
HMGN1 high mobility group nucleosome binding domain 1 -2.00191