CRCGN015_HEPG2_48H:E18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description propyl gallate 11.16 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

127 genes differentially expressed following the CRCGN015_HEPG2_48H:E18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 4.43013
PRKCH protein kinase C, eta 3.99841
KDM5A lysine (K)-specific demethylase 5A 3.84451
ABHD4 abhydrolase domain containing 4 3.70872
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.53141
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 3.4991
NUCB2 nucleobindin 2 3.41793
PLSCR3 phospholipid scramblase 3 3.26543
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.04425
TARP TCR gamma alternate reading frame protein 2.99181
CD8A CD8a molecule 2.94812
TIMP2 TIMP metallopeptidase inhibitor 2 2.88795
SH2D2A SH2 domain containing 2A 2.87828
GABPB1 GA binding protein transcription factor, beta subunit 1 2.85932
CTSW cathepsin W 2.72778
GZMK granzyme K (granzyme 3; tryptase II) 2.71252
TRAK2 trafficking protein, kinesin binding 2 2.68662
ERMP1 endoplasmic reticulum metallopeptidase 1 2.64929
CIDEB cell death-inducing DFFA-like effector b 2.62259
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 2.5975
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 2.53539
ITFG1 integrin alpha FG-GAP repeat containing 1 2.52697
AARS1 alanyl-tRNA synthetase 1 2.51768
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.51046
ITK IL2-inducible T-cell kinase 2.50367
RNF103 ring finger protein 103 2.43794
KLRC4-KLRK1 KLRC4-KLRK1 readthrough 2.4193
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.37875
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 2.37126
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.36039
CST7 cystatin F (leukocystatin) 2.3597
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.35688
TXNRD1 thioredoxin reductase 1 2.35013
PLXND1 plexin D1 2.32082
MAGEF1 melanoma antigen family F1 2.30858
ELF5 E74-like factor 5 (ets domain transcription factor) 2.30304
SEC62 SEC62 homolog (S. cerevisiae) 2.28833
FKBP11 FK506 binding protein 11, 19 kDa 2.27951
TBX21 T-box 21 2.26358
NQO1 NAD(P)H dehydrogenase, quinone 1 2.26247
SQSTM1 sequestosome 1 2.25413
KIAA0319L KIAA0319-like 2.24654
UGDH UDP-glucose 6-dehydrogenase 2.23023
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.2255
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 2.21535
AKR1C3 aldo-keto reductase family 1, member C3 2.20808
IGF2R insulin-like growth factor 2 receptor 2.17736
RAP2A RAP2A, member of RAS oncogene family 2.17266
NKG7 natural killer cell granule protein 7 2.16795
PHF20L1 PHD finger protein 20-like 1 2.129
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 2.12839
PRELID3A PRELI domain containing 3A 2.11914
TZMP1 transition zone microprotein 1 2.10833
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.10697
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.104
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 2.0988
YAF2 YY1 associated factor 2 2.09728
MED23 mediator complex subunit 23 2.09269
CREB3L2 cAMP responsive element binding protein 3-like 2 2.09209
SLC38A6 solute carrier family 38, member 6 2.08466
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.07761
INSL4 insulin-like 4 (placenta) 2.07001
IHH indian hedgehog 2.06914
GK glycerol kinase 2.05145
GPR18 G protein-coupled receptor 18 2.04907
POLK polymerase (DNA directed) kappa 2.04699
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 2.04077
WDR11 WD repeat domain 11 2.03994
ACADSB acyl-CoA dehydrogenase, short/branched chain 2.03757
SERP1 stress-associated endoplasmic reticulum protein 1 2.03519
CENPC centromere protein C 2.00253

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -5.59799
NUP85 nucleoporin 85kDa -5.25371
JPT1 Jupiter microtubule associated homolog 1 -4.93702
ISOC1 isochorismatase domain containing 1 -4.83502
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -4.61634
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -4.32573
RPS4Y1 ribosomal protein S4, Y-linked 1 -4.06684
MRPS7 mitochondrial ribosomal protein S7 -3.78875
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -3.69169
CXADR coxsackie virus and adenovirus receptor -3.58815
KCTD2 potassium channel tetramerization domain containing 2 -3.46073
MT1X metallothionein 1X -3.43025
SAP30BP SAP30 binding protein -3.39961
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -3.23103
MRPL58 mitochondrial ribosomal protein L58 -3.18365
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -3.00731
LRRC42 leucine rich repeat containing 42 -3.00113
DNAAF5 dynein, axonemal, assembly factor 5 -2.95805
RARS1 arginyl-tRNA synthetase 1 -2.9375
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -2.89798
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.81261
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.76335
HRAS Harvey rat sarcoma viral oncogene homolog -2.71179
NME1 NME/NM23 nucleoside diphosphate kinase 1 -2.6847
UBE2O ubiquitin-conjugating enzyme E2O -2.68066
CFAP298 cilia and flagella associated protein 298 -2.66417
PGAM4 phosphoglycerate mutase family member 4 -2.62212
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -2.59591
LRRC47 leucine rich repeat containing 47 -2.56867
IER3 immediate early response 3 -2.54043
MYL9 myosin, light chain 9, regulatory -2.43643
PLS1 plastin 1 -2.42702
BABAM1 BRISC and BRCA1 A complex member 1 -2.40565
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -2.35878
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.3486
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -2.30978
BIRC2 baculoviral IAP repeat containing 2 -2.30738
TMEM164 transmembrane protein 164 -2.27648
CCT8 chaperonin containing TCP1, subunit 8 (theta) -2.27509
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.23726
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 -2.22981
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5 -2.22357
ADSL adenylosuccinate lyase -2.18517
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.15387
TPM2 tropomyosin 2 (beta) -2.13257
NUDC nudC nuclear distribution protein -2.13139
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -2.11503
LAP3 leucine aminopeptidase 3 -2.1024
KLF10 Kruppel-like factor 10 -2.08798
SMIM44 small integral membrane protein 44 -2.0671
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 -2.06322
CCL20 chemokine (C-C motif) ligand 20 -2.0589
IFITM3 interferon induced transmembrane protein 3 -2.05182
OLFM4 olfactomedin 4 -2.04894
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.04135
NOL9 nucleolar protein 9 -2.01174