CRCGN015_HEPG2_48H:E22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description norethindrone 100.09 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

556 genes differentially expressed following the CRCGN015_HEPG2_48H:E22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 5.51586
SNX11 sorting nexin 11 4.76533
ADGRB1 adhesion G protein-coupled receptor B1 4.13975
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 4.05129
BARX2 BARX homeobox 2 3.78528
P3H3 prolyl 3-hydroxylase 3 3.73349
FGF17 fibroblast growth factor 17 3.58854
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 3.51674
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma 3.50536
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) 3.49462
LMX1B LIM homeobox transcription factor 1, beta 3.4834
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 3.47961
DRC4 dynein regulatory complex subunit 4 3.47281
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 3.42551
NKG7 natural killer cell granule protein 7 3.37711
OXT oxytocin/neurophysin I prepropeptide 3.36074
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 3.32437
NSD1 nuclear receptor binding SET domain protein 1 3.32363
ZFPM1 zinc finger protein, FOG family member 1 3.30832
INO80D INO80 complex subunit D 3.29419
VRTN vertebrae development associated 3.28074
POLL polymerase (DNA directed), lambda 3.25009
MORN1 MORN repeat containing 1 3.2297
SIPA1 signal-induced proliferation-associated 1 3.20684
SCT secretin 3.20628
OR10H1 olfactory receptor, family 10, subfamily H, member 1 3.19601
PRB2 proline-rich protein BstNI subfamily 2 3.18555
PKD2L1 polycystic kidney disease 2-like 1 3.17641
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 3.17542
PRH1 proline-rich protein HaeIII subfamily 1 3.15476
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 3.15365
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 3.14547
GNL1 guanine nucleotide binding protein-like 1 3.14526
IDUA iduronidase, alpha-L- 3.1258
GPR27 G protein-coupled receptor 27 3.09648
MYBPC3 myosin binding protein C, cardiac 3.0802
CD180 CD180 molecule 3.0788
KLHL36 kelch-like family member 36 3.07376
KRT3 keratin 3, type II 3.07046
HROB homologous recombination factor with OB-fold 3.06937
CBX1 chromobox homolog 1 3.06172
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 3.05536
MNMIP1 manchette microtubule inner protein 1 3.03223
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 3.02036
KCNA10 potassium channel, voltage gated shaker related subfamily A, member 10 3.00902
NGB neuroglobin 3.00764
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 2.99385
SDK2 sidekick cell adhesion molecule 2 2.97107
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 2.96753
WWC3 WWC family member 3 2.95099
PRB3 proline-rich protein BstNI subfamily 3 2.92231
KRT75 keratin 75, type II 2.92172
POU2F2 POU class 2 homeobox 2 2.91754
EDA2R ectodysplasin A2 receptor 2.8949
ZNF205 zinc finger protein 205 2.89086
AFTPH aftiphilin 2.87464
PSPN persephin 2.87295
EBI3 Epstein-Barr virus induced 3 2.86068
SORBS1 sorbin and SH3 domain containing 1 2.85717
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.8456
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.83988
SOCS1 suppressor of cytokine signaling 1 2.83751
ALPG alkaline phosphatase, germ cell 2.82336
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 2.82058
CLCN7 chloride channel, voltage-sensitive 7 2.81814
TRPV4 transient receptor potential cation channel, subfamily V, member 4 2.81736
PODXL2 podocalyxin-like 2 2.81332
TP53TG5 TP53 target 5 2.80874
EEF1AKMT4-ECE2 EEF1AKMT4-ECE2 readthrough 2.7858
HOXC8 homeobox C8 2.74779
POMT2 protein-O-mannosyltransferase 2 2.74474
ADRB2 adrenoceptor beta 2, surface 2.73927
MYL5 myosin, light chain 5, regulatory 2.73452
EVA1B eva-1 homolog B (C. elegans) 2.72977
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 2.71827
IBSP integrin-binding sialoprotein 2.71369
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 2.69127
RAB3A RAB3A, member RAS oncogene family 2.68847
REM1 RAS (RAD and GEM)-like GTP-binding 1 2.67818
TNP1 transition protein 1 (during histone to protamine replacement) 2.67554
CST7 cystatin F (leukocystatin) 2.6716
CDPF1 cysteine-rich, DPF motif domain containing 1 2.65713
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 2.65561
MATN1 matrilin 1, cartilage matrix protein 2.65478
PLCH2 phospholipase C, eta 2 2.65384
PKD1 polycystic kidney disease 1 (autosomal dominant) 2.65303
UCMA upper zone of growth plate and cartilage matrix associated 2.64614
UPK1B uroplakin 1B 2.64394
CACFD1 calcium channel flower domain containing 1 2.63512
KYAT1 kynurenine aminotransferase 1 2.63463
ADRA2B adrenoceptor alpha 2B 2.63232
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 2.62551
OSGIN1 oxidative stress induced growth inhibitor 1 2.62199
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.60348
ASCC2 activating signal cointegrator 1 complex subunit 2 2.60257
INPP5J inositol polyphosphate-5-phosphatase J 2.59727
KCTD17 potassium channel tetramerization domain containing 17 2.59421
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 2.58957
BIRC7 baculoviral IAP repeat containing 7 2.57771
PARD6A par-6 family cell polarity regulator alpha 2.57055
SLC35F6 solute carrier family 35, member F6 2.56693
FAM53B family with sequence similarity 53, member B 2.56123
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 2.56103
ZNF671 zinc finger protein 671 2.55972
PDCD1 programmed cell death 1 2.5569
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 2.54823
GSTT4 glutathione S-transferase theta 4 2.5464
DOCK2 dedicator of cytokinesis 2 2.54563
CDH22 cadherin 22, type 2 2.53889
KIF25 kinesin family member 25 2.53836
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 2.53456
PAPPA pregnancy-associated plasma protein A, pappalysin 1 2.51599
PRSS21 protease, serine, 21 (testisin) 2.51234
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.51072
EXOSC4 exosome component 4 2.5045
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 2.49913
PRB4 proline-rich protein BstNI subfamily 4 2.488
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like 2.48694
MPPED1 metallophosphoesterase domain containing 1 2.48483
MYH13 myosin, heavy chain 13, skeletal muscle 2.48182
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 2.48058
GRIP2 glutamate receptor interacting protein 2 2.47855
CLN3 ceroid-lipofuscinosis, neuronal 3 2.4782
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 2.47535
JMJD7 jumonji domain containing 7 2.4738
EFNA3 ephrin-A3 2.47309
DUS2 dihydrouridine synthase 2 2.47014
DNAAF8 dynein axonemal assembly factor 8 2.46776
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 2.46387
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 2.46005
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.45346
PAX9 paired box 9 2.45266
CLUH clustered mitochondria (cluA/CLU1) homolog 2.4447
HBQ1 hemoglobin, theta 1 2.44447
RAB40C RAB40C, member RAS oncogene family 2.44356
ASB6 ankyrin repeat and SOCS box containing 6 2.42484
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 2.42449
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 2.42264
PAOX polyamine oxidase (exo-N4-amino) 2.42159
PRDM8 PR domain containing 8 2.42077
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 2.41278
PGLYRP1 peptidoglycan recognition protein 1 2.40555
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 2.40002
RPL39L ribosomal protein L39-like 2.3976
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 2.39759
MYL10 myosin, light chain 10, regulatory 2.3965
SLC61A1 solute carrier family 61 member 1 2.39611
LHX5 LIM homeobox 5 2.39239
ZNF358 zinc finger protein 358 2.3865
CLDN9 claudin 9 2.38555
HEATR6 HEAT repeat containing 6 2.3824
ITFG1 integrin alpha FG-GAP repeat containing 1 2.38013
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 2.37807
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.37722
HAAO 3-hydroxyanthranilate 3,4-dioxygenase 2.36303
CCNE1 cyclin E1 2.36008
MED16 mediator complex subunit 16 2.35982
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 2.35758
GJD2 gap junction protein, delta 2, 36kDa 2.35647
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 2.35304
OVOL3 ovo-like zinc finger 3 2.35144
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.35136
CATSPERH catsper channel auxiliary subunit eta 2.35075
PHF7 PHD finger protein 7 2.33724
TBC1D13 TBC1 domain family, member 13 2.33562
CNTFR ciliary neurotrophic factor receptor 2.33354
MYH14 myosin, heavy chain 14, non-muscle 2.33262
SAMD14 sterile alpha motif domain containing 14 2.3278
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.31971
RWDD2B RWD domain containing 2B 2.31668
HTRA2 HtrA serine peptidase 2 2.31029
INO80B INO80 complex subunit B 2.30391
TMSB4Y thymosin beta 4, Y-linked 2.30094
SQSTM1 sequestosome 1 2.30052
MTA2 metastasis associated 1 family, member 2 2.29835
TRIM25 tripartite motif containing 25 2.29756
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.29615
NPAS1 neuronal PAS domain protein 1 2.29168
IZUMO4 IZUMO family member 4 2.29153
WDR4 WD repeat domain 4 2.28651
TEC tec protein tyrosine kinase 2.28649
F8A2 coagulation factor VIII-associated 2 2.28528
DKKL1 dickkopf-like 1 2.28356
CD70 CD70 molecule 2.28143
AMN amnion associated transmembrane protein 2.28098
TGM5 transglutaminase 5 2.28084
TERF2IP telomeric repeat binding factor 2, interacting protein 2.28033
RBL2 retinoblastoma-like 2 2.27719
GCDH glutaryl-CoA dehydrogenase 2.27611
RFX2 regulatory factor X, 2 (influences HLA class II expression) 2.27533
PCDHB13 protocadherin beta 13 2.26837
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 2.26724
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.26631
A4GALT alpha 1,4-galactosyltransferase 2.26021
TLX1 T-cell leukemia homeobox 1 2.25903
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 2.25831
YIPF2 Yip1 domain family, member 2 2.25707
RPP25 ribonuclease P/MRP 25kDa subunit 2.25322
CTDNEP1 CTD nuclear envelope phosphatase 1 2.25231
EDC4 enhancer of mRNA decapping 4 2.24944
PCDHGA9 protocadherin gamma subfamily A, 9 2.24407
SAP30 Sin3A-associated protein, 30kDa 2.24245
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 2.23781
MPV17 MpV17 mitochondrial inner membrane protein 2.22991
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 2.22778
PAX7 paired box 7 2.22736
CTSF cathepsin F 2.227
UNKL unkempt family zinc finger-like 2.22372
MACROD1 MACRO domain containing 1 2.22072
KRI1 KRI1 homolog (S. cerevisiae) 2.2203
BORCS6 BLOC-1 related complex subunit 6 2.21985
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) 2.21975
IFI30 interferon, gamma-inducible protein 30 2.21716
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.21527
TMEM131 transmembrane protein 131 2.21426
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) 2.20737
TYK2 tyrosine kinase 2 2.20659
LRRC61 leucine rich repeat containing 61 2.20467
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 2.20218
FGF6 fibroblast growth factor 6 2.19986
SRPX sushi-repeat containing protein, X-linked 2.19974
DEF6 differentially expressed in FDCP 6 homolog (mouse) 2.1991
POGLUT2 protein O-glucosyltransferase 2 2.19814
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 2.1972
ABHD4 abhydrolase domain containing 4 2.19686
GJA3 gap junction protein, alpha 3, 46kDa 2.19597
LOC107985101 uncharacterized LOC107985101 2.19419
GRM1 glutamate receptor, metabotropic 1 2.18776
SCTR secretin receptor 2.18762
LTC4S leukotriene C4 synthase 2.18231
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 2.18146
NCLN nicalin 2.18115
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 2.17974
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 2.17706
SRR serine racemase 2.17315
GRAMD1B GRAM domain containing 1B 2.1725
BCAR3 breast cancer anti-estrogen resistance 3 2.1723
PTP4A3 protein tyrosine phosphatase type IVA, member 3 2.16733
ZNF821 zinc finger protein 821 2.1673
E2F1 E2F transcription factor 1 2.1631
GFI1 growth factor independent 1 transcription repressor 2.15896
ZSWIM8 zinc finger, SWIM-type containing 8 2.15765
FAT2 FAT atypical cadherin 2 2.15482
UBXN1 UBX domain protein 1 2.15194
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 2.1477
GAA glucosidase, alpha; acid 2.14356
KRT85 keratin 85, type II 2.14169
AMHR2 anti-Mullerian hormone receptor, type II 2.13887
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 2.13729
SSTR5 somatostatin receptor 5 2.13536
TUBA3C tubulin, alpha 3c 2.13499
NQO1 NAD(P)H dehydrogenase, quinone 1 2.1337
TULP1 tubby like protein 1 2.13289
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.1287
CDK5RAP2 CDK5 regulatory subunit associated protein 2 2.12593
LPO lactoperoxidase 2.12393
LMF1 lipase maturation factor 1 2.114
KLK14 kallikrein-related peptidase 14 2.10582
CD79B CD79b molecule, immunoglobulin-associated beta 2.10479
NDOR1 NADPH dependent diflavin oxidoreductase 1 2.10281
POU2AF1 POU class 2 associating factor 1 2.09883
CRNN cornulin 2.09718
LMO1 LIM domain only 1 (rhombotin 1) 2.09498
RHCG Rh family, C glycoprotein 2.09327
SKI SKI proto-oncogene 2.09094
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 2.08963
POLA2 polymerase (DNA directed), alpha 2, accessory subunit 2.08683
ZNF248 zinc finger protein 248 2.0857
HAMP hepcidin antimicrobial peptide 2.08448
NPY4R2 neuropeptide Y receptor Y4-2 2.08395
CCKBR cholecystokinin B receptor 2.07765
TAAR5 trace amine associated receptor 5 2.07715
HRH3 histamine receptor H3 2.07675
KLC3 kinesin light chain 3 2.07644
ZNF276 zinc finger protein 276 2.07576
COMMD9 COMM domain containing 9 2.0757
SLAMF1 signaling lymphocytic activation molecule family member 1 2.07555
ASIC4 acid sensing (proton gated) ion channel family member 4 2.07372
NEU2 sialidase 2 (cytosolic sialidase) 2.06923
GALR2 galanin receptor 2 2.06492
SMG6 SMG6 nonsense mediated mRNA decay factor 2.06393
SAR1A secretion associated, Ras related GTPase 1A 2.06263
DGKQ diacylglycerol kinase, theta 110kDa 2.06143
NLRP4 NLR family, pyrin domain containing 4 2.05947
KEAP1 kelch-like ECH-associated protein 1 2.05785
APOA4 apolipoprotein A-IV 2.05454
PLXNA1 plexin A1 2.05173
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 2.04863
TRAPPC2L trafficking protein particle complex 2-like 2.04766
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 2.04505
PNMA3 paraneoplastic Ma antigen 3 2.04393
GSTM2 glutathione S-transferase mu 2 (muscle) 2.04203
MYO19 myosin XIX 2.0418
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 2.03948
RHOD ras homolog family member D 2.03827
VPS9D1 VPS9 domain containing 1 2.03793
B3GAT3 beta-1,3-glucuronyltransferase 3 2.03692
PADI1 peptidyl arginine deiminase, type I 2.03507
MAPT microtubule-associated protein tau 2.03494
MATN4 matrilin 4 2.03471
GJA8 gap junction protein, alpha 8, 50kDa 2.03212
ACTL7B actin-like 7B 2.02945
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.02716
CGB8 chorionic gonadotropin, beta polypeptide 8 2.02681
MEGF9 multiple EGF-like-domains 9 2.02614
KCNH4 potassium channel, voltage gated eag related subfamily H, member 4 2.02602
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.02601
IFI35 interferon-induced protein 35 2.02255
SH3GL1 SH3-domain GRB2-like 1 2.02068
RAX retina and anterior neural fold homeobox 2.02031
AAMDC adipogenesis associated, Mth938 domain containing 2.02012
MTCL1 microtubule crosslinking factor 1 2.01847
SLC38A7 solute carrier family 38, member 7 2.01835
TLE6 transducin-like enhancer of split 6 2.01755
NEUROG1 neurogenin 1 2.01733
SHH sonic hedgehog 2.0152
TBC1D2 TBC1 domain family, member 2 2.01243
MYL7 myosin, light chain 7, regulatory 2.0079
CHRD chordin 2.00694
GRM4 glutamate receptor, metabotropic 4 2.00454
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 2.00279
VEGFB vascular endothelial growth factor B 2.0026

decreased expression

Symbol Name Standardized Value
TM9SF3 transmembrane 9 superfamily member 3 -5.23861
NCK1 NCK adaptor protein 1 -4.98942
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.5243
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -4.42137
S100P S100 calcium binding protein P -4.31894
LOC124907782 dual specificity protein phosphatase 22 -4.21482
XPO7 exportin 7 -3.97962
PON2 paraoxonase 2 -3.90244
CNBP CCHC-type zinc finger, nucleic acid binding protein -3.79642
RINT1 RAD50 interactor 1 -3.73013
CENPE centromere protein E, 312kDa -3.71205
SRFBP1 serum response factor binding protein 1 -3.62564
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -3.62541
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -3.59119
CXADR coxsackie virus and adenovirus receptor -3.51857
KRT2 keratin 2, type II -3.4423
CDC20 cell division cycle 20 -3.30046
FAIM Fas apoptotic inhibitory molecule -3.28979
FNTA farnesyltransferase, CAAX box, alpha -3.24908
USP3 ubiquitin specific peptidase 3 -3.10877
WBP11 WW domain binding protein 11 -3.10402
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -3.07479
ACOT9 acyl-CoA thioesterase 9 -3.07467
PECR peroxisomal trans-2-enoyl-CoA reductase -3.07026
TRIT1 tRNA isopentenyltransferase 1 -3.0372
MACF1 microtubule-actin crosslinking factor 1 -2.9898
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 -2.98279
HNRNPM heterogeneous nuclear ribonucleoprotein M -2.98107
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 -2.97484
HPRT1 hypoxanthine phosphoribosyltransferase 1 -2.95844
TDG thymine-DNA glycosylase -2.95373
KIF20A kinesin family member 20A -2.95139
RWDD3 RWD domain containing 3 -2.94083
SARAF store-operated calcium entry-associated regulatory factor -2.9231
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa -2.89339
PUF60 poly-U binding splicing factor 60KDa -2.86502
COG2 component of oligomeric golgi complex 2 -2.8636
ZBTB35 zinc finger and BTB domain containing 35 -2.82119
RAB23 RAB23, member RAS oncogene family -2.79138
PLS3 plastin 3 -2.77848
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -2.77439
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -2.76794
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) -2.76421
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.76413
GARS1 glycyl-tRNA synthetase 1 -2.7628
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -2.76234
YAF2 YY1 associated factor 2 -2.75694
ADSL adenylosuccinate lyase -2.73851
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.71549
KPLCE KPRP N-terminal and LCE C-terminal like protein -2.71076
CDO1 cysteine dioxygenase type 1 -2.67723
TSPAN6 tetraspanin 6 -2.6731
THSD1 thrombospondin, type I, domain containing 1 -2.65595
ACSL6 acyl-CoA synthetase long-chain family member 6 -2.65562
ZBED4 zinc finger, BED-type containing 4 -2.65473
TEX10 testis expressed 10 -2.64078
SPRYD7 SPRY domain containing 7 -2.62892
RAB5A RAB5A, member RAS oncogene family -2.62679
NOP2 NOP2 nucleolar protein -2.62379
ANXA5 annexin A5 -2.61542
PLIN2 perilipin 2 -2.61542
RHOB ras homolog family member B -2.61542
ZNF7 zinc finger protein 7 -2.6142
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.61344
R3HCC1L R3H domain and coiled-coil containing 1-like -2.60757
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 -2.59795
DSG1 desmoglein 1 -2.59083
SALL1 spalt-like transcription factor 1 -2.58892
MT1X metallothionein 1X -2.58666
SLC35F2 solute carrier family 35, member F2 -2.58342
HIGD1A HIG1 hypoxia inducible domain family, member 1A -2.57903
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -2.57754
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.57636
CYCS cytochrome c, somatic -2.56947
ILKAP integrin-linked kinase-associated serine/threonine phosphatase -2.56454
PMM2 phosphomannomutase 2 -2.56051
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.55735
COPS5 COP9 signalosome subunit 5 -2.54962
PDLIM1 PDZ and LIM domain 1 -2.54879
TMED2 transmembrane emp24 domain trafficking protein 2 -2.53941
FYN FYN proto-oncogene, Src family tyrosine kinase -2.53903
LORICRIN loricrin cornified envelope precursor protein -2.52398
GGCT gamma-glutamylcyclotransferase -2.52297
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.52239
CHP2 calcineurin-like EF-hand protein 2 -2.52236
CASD1 CAS1 domain containing 1 -2.52069
CDK5RAP1 CDK5 regulatory subunit associated protein 1 -2.4943
RPF1 ribosome production factor 1 homolog (S. cerevisiae) -2.48654
LCE2B late cornified envelope 2B -2.47682
MRPL42 mitochondrial ribosomal protein L42 -2.4755
GASK1B golgi associated kinase 1B -2.47177
FBLN5 fibulin 5 -2.46672
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -2.46027
KIF13B kinesin family member 13B -2.44836
BRD1 bromodomain containing 1 -2.44413
ITGA9 integrin, alpha 9 -2.44379
INAVA innate immunity activator -2.44217
SMIM41 small integral membrane protein 41 -2.43696
RNF34 ring finger protein 34, E3 ubiquitin protein ligase -2.42626
NUP42 nucleoporin 42 -2.40804
MTERF3 mitochondrial transcription termination factor 3 -2.40006
TTC13 tetratricopeptide repeat domain 13 -2.39678
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -2.39545
H2AJ H2A.J histone -2.38924
DZIP3 DAZ interacting zinc finger protein 3 -2.38305
PUM3 pumilio RNA binding family member 3 -2.38113
NT5DC2 5'-nucleotidase domain containing 2 -2.37546
MARCHF3 membrane associated ring-CH-type finger 3 -2.36217
DERA deoxyribose-phosphate aldolase (putative) -2.36026
JAM3 junctional adhesion molecule 3 -2.3439
NEK2 NIMA-related kinase 2 -2.34362
GGPS1 geranylgeranyl diphosphate synthase 1 -2.33296
GYG1 glycogenin 1 -2.32224
ARF6 ADP-ribosylation factor 6 -2.32058
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 -2.32006
RTRAF RNA transcription, translation and transport factor -2.31701
NGLY1 N-glycanase 1 -2.31661
LACTB2 lactamase, beta 2 -2.31606
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit -2.31508
RIC8B RIC8 guanine nucleotide exchange factor B -2.31257
DPYSL2 dihydropyrimidinase-like 2 -2.31243
PIGH phosphatidylinositol glycan anchor biosynthesis, class H -2.30941
NUP37 nucleoporin 37kDa -2.30096
GTF3A general transcription factor IIIA -2.29203
NUP62CL nucleoporin 62kDa C-terminal like -2.28941
NAE1 NEDD8 activating enzyme E1 subunit 1 -2.28607
RLF rearranged L-myc fusion -2.2837
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C -2.2813
NGRN neugrin, neurite outgrowth associated -2.28091
SINHCAF SIN3-HDAC complex associated factor -2.27373
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -2.27328
TUBB2A tubulin, beta 2A class IIa -2.2656
LRRC47 leucine rich repeat containing 47 -2.26123
NANOG Nanog homeobox -2.25978
KIZ kizuna centrosomal protein -2.25943
ARPP19 cAMP-regulated phosphoprotein, 19kDa -2.25708
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 -2.25401
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase -2.24969
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -2.24633
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 -2.23136
MRPL15 mitochondrial ribosomal protein L15 -2.22372
TYRP1 tyrosinase-related protein 1 -2.21879
MDH2 malate dehydrogenase 2, NAD (mitochondrial) -2.21625
FGF9 fibroblast growth factor 9 -2.21348
FKBP1C FK506 binding protein 1C -2.21115
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa -2.20943
PUS7 pseudouridylate synthase 7 (putative) -2.20444
NIPAL2 NIPA-like domain containing 2 -2.20044
PTK2 protein tyrosine kinase 2 -2.19896
PSAT1 phosphoserine aminotransferase 1 -2.19628
WDR45B WD repeat domain 45B -2.19576
NUDC nudC nuclear distribution protein -2.19506
GRAMD4 GRAM domain containing 4 -2.19424
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) -2.19288
KRT1 keratin 1, type II -2.18926
SGPP1 sphingosine-1-phosphate phosphatase 1 -2.18748
ZFAND1 zinc finger, AN1-type domain 1 -2.17234
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase -2.17111
TMSB15B thymosin beta 15B -2.17066
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -2.1695
RIOK3 RIO kinase 3 -2.16934
ORC5 origin recognition complex, subunit 5 -2.16788
FERRY3 FERRY endosomal RAB5 effector complex subunit 3 -2.16513
DCTN4 dynactin 4 (p62) -2.15902
ATP5F1B ATP synthase F1 subunit beta -2.15432
IFFO1 intermediate filament family orphan 1 -2.15081
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 -2.14571
PHF2 PHD finger protein 2 -2.14487
GID8 GID complex subunit 8 -2.14301
PEX2 peroxisomal biogenesis factor 2 -2.13992
TMEM254 transmembrane protein 254 -2.13864
VSIG2 V-set and immunoglobulin domain containing 2 -2.13794
COPS7A COP9 signalosome subunit 7A -2.12968
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -2.12674
OXR1 oxidation resistance 1 -2.12449
MOB4 MOB family member 4, phocein -2.12435
CBX3 chromobox homolog 3 -2.12302
ZNF226 zinc finger protein 226 -2.11962
GOLT1B golgi transport 1B -2.11443
ZNF227 zinc finger protein 227 -2.11093
TGFBI transforming growth factor, beta-induced, 68kDa -2.11023
UFM1 ubiquitin-fold modifier 1 -2.10611
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 -2.10461
SAYSD1 SAYSVFN motif domain containing 1 -2.10342
DMAC2L distal membrane arm assembly component 2 like -2.10022
ETF1 eukaryotic translation termination factor 1 -2.09228
KXD1 KxDL motif containing 1 -2.09055
LIAS lipoic acid synthetase -2.0903
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 -2.08848
ZNHIT6 zinc finger, HIT-type containing 6 -2.08187
TAGLN2 transgelin 2 -2.08132
TSNAX translin-associated factor X -2.08057
NID1 nidogen 1 -2.07847
ATP5PB ATP synthase peripheral stalk-membrane subunit b -2.07842
CCT2 chaperonin containing TCP1, subunit 2 (beta) -2.07767
TTC12 tetratricopeptide repeat domain 12 -2.07597
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 -2.07153
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -2.07034
BIN3 bridging integrator 3 -2.07014
LOC124907012 endogenous retrovirus group K member 7 Env polyprotein-like -2.06921
YBX3 Y box binding protein 3 -2.06746
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.06672
CLDND1 claudin domain containing 1 -2.06474
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -2.06312
RNFT1 ring finger protein, transmembrane 1 -2.06027
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -2.05936
HCFC2 host cell factor C2 -2.05874
POLR1F RNA polymerase I subunit F -2.05668
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.05645
HNRNPK heterogeneous nuclear ribonucleoprotein K -2.04549
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 -2.04392
TCF21 transcription factor 21 -2.04068
RNF14 ring finger protein 14 -2.03933
CERK ceramide kinase -2.03791
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -2.03449
MTCH1 mitochondrial carrier 1 -2.03334
S100A10 S100 calcium binding protein A10 -2.03316
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.03261
KIF15 kinesin family member 15 -2.03191
KNTC1 kinetochore associated 1 -2.0315
CSRP2 cysteine and glycine-rich protein 2 -2.02833
TMX2 thioredoxin-related transmembrane protein 2 -2.02821
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -2.02703
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) -2.02651
MRPS22 mitochondrial ribosomal protein S22 -2.02601
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -2.02145
DDA1 DET1 and DDB1 associated 1 -2.01885
CCN2 cellular communication network factor 2 -2.0181
ART3 ADP-ribosyltransferase 3 -2.01791
DPP6 dipeptidyl-peptidase 6 -2.01446
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) -2.01067
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 -2.008
SNRPA small nuclear ribonucleoprotein polypeptide A -2.00045
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -2.00014