CRCGN015_HEPG2_48H:E23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description norethindrone 33.36 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN015_HEPG2_48H:E23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 4.84662
CBR3 carbonyl reductase 3 4.43536
MAP7 microtubule-associated protein 7 4.30487
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.21506
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.74185
CRYM crystallin, mu 2.61172
NSG2 neuronal vesicle trafficking associated 2 2.51064
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.46238
SYN1 synapsin I 2.39584
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.28083
SNAP91 synaptosomal-associated protein, 91kDa 2.24207
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 2.15566
SH3GL2 SH3-domain GRB2-like 2 2.14166
SNCB synuclein, beta 2.12026
QDPR quinoid dihydropteridine reductase 2.09086
RGS7 regulator of G-protein signaling 7 2.0806
WDR11 WD repeat domain 11 2.06972
STMN2 stathmin 2 2.03659

decreased expression

Symbol Name Standardized Value
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -7.41304
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.86533
APOA2 apolipoprotein A-II -3.28408
ATG4A autophagy related 4A, cysteine peptidase -2.77287
MT1X metallothionein 1X -2.6096
APOH apolipoprotein H (beta-2-glycoprotein I) -2.56479
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -2.48629
CLCNKA chloride channel, voltage-sensitive Ka -2.42172
FBXL12 F-box and leucine-rich repeat protein 12 -2.34504
RFX5 regulatory factor X, 5 (influences HLA class II expression) -2.29767
HEBP1 heme binding protein 1 -2.23969
ZGPAT zinc finger, CCCH-type with G patch domain -2.21931
TMEM164 transmembrane protein 164 -2.10168