CRCGN015_HEPG2_48H:F06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description BRD-K63993117 11.39 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

20 genes differentially expressed following the CRCGN015_HEPG2_48H:F06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MCOLN1 mucolipin 1 3.95363
GRB10 growth factor receptor-bound protein 10 3.06953
CCDC92 coiled-coil domain containing 92 2.99825
SSBP2 single-stranded DNA binding protein 2 2.71935
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.7028
ILK integrin-linked kinase 2.22836
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.03862

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.27922
CCNB2 cyclin B2 -3.52039
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -3.14019
DUSP6 dual specificity phosphatase 6 -3.10667
MACF1 microtubule-actin crosslinking factor 1 -3.09891
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -3.0447
HPRT1 hypoxanthine phosphoribosyltransferase 1 -2.86092
C2CD5 C2 calcium-dependent domain containing 5 -2.61811
DNM1L dynamin 1-like -2.57153
PLS1 plastin 1 -2.4979
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -2.29857
MT1X metallothionein 1X -2.18716
BMAL2 basic helix-loop-helix ARNT like 2 -2.04286