CRCGN015_HEPG2_48H:F14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzoic acid, sodium 33.82 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

156 genes differentially expressed following the CRCGN015_HEPG2_48H:F14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CASC3 cancer susceptibility candidate 3 4.22114
IL4R interleukin 4 receptor 3.58197
MAP7 microtubule-associated protein 7 3.56572
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 3.17559
AARS1 alanyl-tRNA synthetase 1 3.04945
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 3.03072
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 3.01797
ARMC6 armadillo repeat containing 6 2.95674
NNT nicotinamide nucleotide transhydrogenase 2.81296
CRTAM cytotoxic and regulatory T cell molecule 2.71469
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.66368
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.61057
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 2.60577
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 2.6047
NPTN neuroplastin 2.58303
CMTR1 cap methyltransferase 1 2.55151
PEX11B peroxisomal biogenesis factor 11 beta 2.51458
MAGEA8 melanoma antigen family A8 2.45092
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.38863
PHKB phosphorylase kinase, beta 2.36915
SYMPK symplekin 2.33272
GSTA4 glutathione S-transferase alpha 4 2.32895
CCDC86 coiled-coil domain containing 86 2.32874
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) 2.32626
UBE2M ubiquitin-conjugating enzyme E2M 2.32388
TARP TCR gamma alternate reading frame protein 2.31929
PCDHB12 protocadherin beta 12 2.3179
FKBP8 FK506 binding protein 8, 38kDa 2.31499
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.30944
MED15 mediator complex subunit 15 2.30274
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 2.28602
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 2.2752
MED24 mediator complex subunit 24 2.26976
RHEB Ras homolog enriched in brain 2.26272
BRD9 bromodomain containing 9 2.25821
ZNF282 zinc finger protein 282 2.21423
GPR18 G protein-coupled receptor 18 2.21115
ELP5 elongator acetyltransferase complex subunit 5 2.21036
ZDHHC6 zinc finger, DHHC-type containing 6 2.20401
PDCD6 programmed cell death 6 2.20052
CSK c-src tyrosine kinase 2.18678
CUL7 cullin 7 2.18393
IRF8 interferon regulatory factor 8 2.17096
PGAM4 phosphoglycerate mutase family member 4 2.15914
MYOD1 myogenic differentiation 1 2.1585
RPL29 ribosomal protein L29 2.15704
USP18 ubiquitin specific peptidase 18 2.15143
FAM216A family with sequence similarity 216, member A 2.1514
MECR mitochondrial trans-2-enoyl-CoA reductase 2.12644
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 2.10538
RAB27A RAB27A, member RAS oncogene family 2.10524
GTF2A2 general transcription factor IIA, 2, 12kDa 2.10218
GOLGA8F golgin A8 family, member F 2.10097
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa 2.10006
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 2.09779
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 2.09077
LAG3 lymphocyte-activation gene 3 2.08879
GZMM granzyme M (lymphocyte met-ase 1) 2.08818
ZNF692 zinc finger protein 692 2.08481
GPHRA golgi pH regulator A 2.08022
LRRC31 leucine rich repeat containing 31 2.08004
RNPS1 RNA binding protein S1, serine-rich domain 2.0767
UBA3 ubiquitin-like modifier activating enzyme 3 2.07074
PUS1 pseudouridylate synthase 1 2.06969
ZNF571 zinc finger protein 571 2.06848
NISCH nischarin 2.06674
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.05766
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 2.05599
ZNF426 zinc finger protein 426 2.05455
NT5C 5', 3'-nucleotidase, cytosolic 2.05346
MRPL4 mitochondrial ribosomal protein L4 2.05102
ABHD17A abhydrolase domain containing 17A 2.04631
RPL18 ribosomal protein L18 2.04242
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa 2.03952
ERMP1 endoplasmic reticulum metallopeptidase 1 2.03014
DUSP14 dual specificity phosphatase 14 2.02955
CDC20 cell division cycle 20 2.02865
ZNF862 zinc finger protein 862 2.02734
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 2.02131
FSTL3 follistatin-like 3 (secreted glycoprotein) 2.01926
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.01658
BIN2 bridging integrator 2 2.01144
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 2.00507
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle 2.00478
ZBTB32 zinc finger and BTB domain containing 32 2.00356

decreased expression

Symbol Name Standardized Value
MT1X metallothionein 1X -5.20773
MTFR1 mitochondrial fission regulator 1 -3.74527
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.65316
PUF60 poly-U binding splicing factor 60KDa -3.52456
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -3.4849
HEATR1 HEAT repeat containing 1 -3.44681
SCRIB scribbled planar cell polarity protein -3.3285
PRCP prolylcarboxypeptidase (angiotensinase C) -3.19925
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -3.12797
OSBPL11 oxysterol binding protein-like 11 -3.0651
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.92757
ENY2 enhancer of yellow 2 homolog (Drosophila) -2.91985
ZNF623 zinc finger protein 623 -2.87781
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.67646
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.66978
HSPA12A heat shock 70kDa protein 12A -2.65843
MCUR1 mitochondrial calcium uniporter regulator 1 -2.64964
CHD9NB CHD9 neighbor -2.64047
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.63086
LYRM1 LYR motif containing 1 -2.62736
SYBU syntabulin (syntaxin-interacting) -2.61649
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.5692
NGRN neugrin, neurite outgrowth associated -2.54958
NUP93 nucleoporin 93kDa -2.53373
RPN1 ribophorin I -2.47005
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.4505
ZNF217 zinc finger protein 217 -2.42185
AGO1 argonaute RISC catalytic component 1 -2.39226
SMNDC1 survival motor neuron domain containing 1 -2.39064
JRKL JRK-like -2.38573
ZC3H3 zinc finger CCCH-type containing 3 -2.36944
ZNF250 zinc finger protein 250 -2.368
TOPBP1 topoisomerase (DNA) II binding protein 1 -2.36564
SARAF store-operated calcium entry-associated regulatory factor -2.36183
DAZAP2 DAZ associated protein 2 -2.32877
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 -2.30597
ANXA7 annexin A7 -2.29957
KIFBP kinesin family binding protein -2.29805
GSDMD gasdermin D -2.29573
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.27615
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -2.27232
CRYBG1 crystallin beta-gamma domain containing 1 -2.25496
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -2.22891
UBQLN2 ubiquilin 2 -2.21973
SLC31A2 solute carrier family 31 (copper transporter), member 2 -2.21185
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -2.18852
SCUBE2 signal peptide, CUB domain, EGF-like 2 -2.17248
MKNK2 MAP kinase interacting serine/threonine kinase 2 -2.16196
AGO2 argonaute RISC catalytic component 2 -2.15408
SMIM40 small integral membrane protein 40 -2.14817
WBP1L WW domain binding protein 1-like -2.1293
GMPS guanine monphosphate synthase -2.12815
CCNH cyclin H -2.12315
BCL10 B-cell CLL/lymphoma 10 -2.12261
CA6 carbonic anhydrase VI -2.10561
TBPL1 TBP-like 1 -2.10277
SAP130 Sin3A-associated protein, 130kDa -2.09683
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.09365
C2CD3 C2 calcium-dependent domain containing 3 -2.09316
PCNP PEST proteolytic signal containing nuclear protein -2.09119
VTCN1 V-set domain containing T cell activation inhibitor 1 -2.09113
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -2.08367
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.07486
FNBP1L formin binding protein 1-like -2.06661
JADE3 jade family PHD finger 3 -2.05271
IL1R1 interleukin 1 receptor, type I -2.05167
PHF20L1 PHD finger protein 20-like 1 -2.04576
STARD7 StAR-related lipid transfer (START) domain containing 7 -2.03821
IGFBP7 insulin-like growth factor binding protein 7 -2.01953
GPR143 G protein-coupled receptor 143 -2.01678
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.00257