CRCGN015_HEPG2_48H:F15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzoic acid, sodium 11.27 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

92 genes differentially expressed following the CRCGN015_HEPG2_48H:F15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TRIB1 tribbles pseudokinase 1 3.8086
RHEB Ras homolog enriched in brain 2.678
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 2.65735
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 2.63555
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.5913
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 2.58595
UBE2S ubiquitin-conjugating enzyme E2S 2.5112
IGF1R insulin-like growth factor 1 receptor 2.49623
CASC3 cancer susceptibility candidate 3 2.4853
CCNE1 cyclin E1 2.4597
TUBB2A tubulin, beta 2A class IIa 2.37919
NUSAP1 nucleolar and spindle associated protein 1 2.36888
CD8A CD8a molecule 2.3276
TMEM50A transmembrane protein 50A 2.2969
AARS1 alanyl-tRNA synthetase 1 2.28885
MED24 mediator complex subunit 24 2.2679
TUBB4B tubulin, beta 4B class IVb 2.26275
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.22035
CD151 CD151 molecule (Raph blood group) 2.1564
THTPA thiamine triphosphatase 2.1244
MYOD1 myogenic differentiation 1 2.1097
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.09765
REPS1 RALBP1 associated Eps domain containing 1 2.09125
SYNGAP1 synaptic Ras GTPase activating protein 1 2.0865
LRRC59 leucine rich repeat containing 59 2.07425
GSTZ1 glutathione S-transferase zeta 1 2.07065
FOSL1 FOS-like antigen 1 2.0597
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 2.0559
TMEM260 transmembrane protein 260 2.0317
TSPAN4 tetraspanin 4 2.0304
PLBD1 phospholipase B domain containing 1 2.02545
ITFG1 integrin alpha FG-GAP repeat containing 1 2.02375
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.02
MPDU1 mannose-P-dolichol utilization defect 1 2.0181
CDC45 cell division cycle 45 2.01795
FAM3C family with sequence similarity 3, member C 2.001

decreased expression

Symbol Name Standardized Value
APOH apolipoprotein H (beta-2-glycoprotein I) -5.10845
COG7 component of oligomeric golgi complex 7 -4.6178
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.5152
FOXJ3 forkhead box J3 -3.77292
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.68478
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -3.5671
CXADR coxsackie virus and adenovirus receptor -3.48205
LYRM1 LYR motif containing 1 -3.4713
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.24685
MAPK13 mitogen-activated protein kinase 13 -3.22395
HEBP1 heme binding protein 1 -3.19495
LCMT1 leucine carboxyl methyltransferase 1 -3.0666
UFM1 ubiquitin-fold modifier 1 -2.99885
MTFR1 mitochondrial fission regulator 1 -2.93957
UBFD1 ubiquitin family domain containing 1 -2.91095
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.84045
DCTN5 dynactin 5 (p25) -2.7732
SCNN1B sodium channel, non voltage gated 1 beta subunit -2.71645
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) -2.5908
PALB2 partner and localizer of BRCA2 -2.54155
MED8 mediator complex subunit 8 -2.5097
CAMLG calcium modulating ligand -2.4544
ARHGAP17 Rho GTPase activating protein 17 -2.4415
PROSER1 proline and serine rich 1 -2.42585
NGRN neugrin, neurite outgrowth associated -2.3699
ASPHD1 aspartate beta-hydroxylase domain containing 1 -2.3634
THUMPD1 THUMP domain containing 1 -2.34565
RPN1 ribophorin I -2.3148
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase -2.2571
SGF29 SAGA complex associated factor 29 -2.2418
SMNDC1 survival motor neuron domain containing 1 -2.23345
CCL21 chemokine (C-C motif) ligand 21 -2.22315
PEX13 peroxisomal biogenesis factor 13 -2.17775
PRCP prolylcarboxypeptidase (angiotensinase C) -2.17065
VPS33B vacuolar protein sorting 33 homolog B (yeast) -2.16943
SAP30L SAP30-like -2.1619
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -2.1392
TXNL4B thioredoxin-like 4B -2.1077
RAB5B RAB5B, member RAS oncogene family -2.10255
TIGAR TP53 induced glycolysis regulatory phosphatase -2.10095
SLC61A1 solute carrier family 61 member 1 -2.09975
TSLIG3A tRNA splicing ligase complex subunit 3A -2.0993
RNF40 ring finger protein 40, E3 ubiquitin protein ligase -2.0862
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) -2.08367
ZNF629 zinc finger protein 629 -2.0764
FLCN folliculin -2.0687
CCNH cyclin H -2.0531
TOPBP1 topoisomerase (DNA) II binding protein 1 -2.0465
TF transferrin -2.04131
PDGFRL platelet-derived growth factor receptor-like -2.03505
WDR3 WD repeat domain 3 -2.03445
DDIT4 DNA-damage-inducible transcript 4 -2.0336
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -2.0299
RFX5 regulatory factor X, 5 (influences HLA class II expression) -2.02583
APOA2 apolipoprotein A-II -2.02583
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -2.0234