CRCGN015_HEPG2_48H:F17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxymetholone 33.99 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

90 genes differentially expressed following the CRCGN015_HEPG2_48H:F17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KIFBP kinesin family binding protein 4.2768
ABHD4 abhydrolase domain containing 4 4.21619
PRKCQ protein kinase C, theta 4.07432
FPGS folylpolyglutamate synthase 3.5571
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 3.3789
TXNRD1 thioredoxin reductase 1 2.92472
BYSL bystin-like 2.83186
TLCD3A TLC domain containing 3A 2.81303
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.78613
MOK MOK protein kinase 2.68336
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.65659
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.63888
UGDH UDP-glucose 6-dehydrogenase 2.50979
TRIM32 tripartite motif containing 32 2.47772
PRMT5 protein arginine methyltransferase 5 2.40984
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 2.4091
KEAP1 kelch-like ECH-associated protein 1 2.40389
RAB5IF RAB5 interacting factor 2.37591
CLTB clathrin, light chain B 2.3749
NQO1 NAD(P)H dehydrogenase, quinone 1 2.37299
NANOS3 nanos homolog 3 (Drosophila) 2.33733
DKK4 dickkopf WNT signaling pathway inhibitor 4 2.33501
G6PC3 glucose 6 phosphatase, catalytic, 3 2.27106
EXOSC5 exosome component 5 2.26735
ERMP1 endoplasmic reticulum metallopeptidase 1 2.26318
TRIB1 tribbles pseudokinase 1 2.2543
SCAND1 SCAN domain containing 1 2.25196
ITGB5 integrin, beta 5 2.14557
RABGGTA Rab geranylgeranyltransferase, alpha subunit 2.10354
SQSTM1 sequestosome 1 2.10346
MAPK13 mitogen-activated protein kinase 13 2.07913
TMEM147 transmembrane protein 147 2.05221
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 2.03106
SQOR sulfide quinone oxidoreductase 2.02792
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.02185
NCLN nicalin 2.01828
ATP13A1 ATPase type 13A1 2.01369
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 2.00098

decreased expression

Symbol Name Standardized Value
CXADR coxsackie virus and adenovirus receptor -6.40425
IL17RB interleukin 17 receptor B -4.73706
SNX7 sorting nexin 7 -4.4905
BIRC2 baculoviral IAP repeat containing 2 -4.33963
COG2 component of oligomeric golgi complex 2 -3.82047
TRAPPC3 trafficking protein particle complex 3 -3.69488
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.69238
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.40374
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.24208
TF transferrin -3.14075
MT1X metallothionein 1X -3.07601
APOA2 apolipoprotein A-II -3.03037
RBM34 RNA binding motif protein 34 -2.88015
TM9SF3 transmembrane 9 superfamily member 3 -2.7697
FBF1 Fas (TNFRSF6) binding factor 1 -2.73936
GGPS1 geranylgeranyl diphosphate synthase 1 -2.66419
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -2.51365
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 -2.47737
BIRC3 baculoviral IAP repeat containing 3 -2.40874
WFDC1 WAP four-disulfide core domain 1 -2.40319
NBPF10 neuroblastoma breakpoint family, member 10 -2.3265
LAPTM4A lysosomal protein transmembrane 4 alpha -2.30233
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -2.26657
NR2C2 nuclear receptor subfamily 2, group C, member 2 -2.2327
ZNF562 zinc finger protein 562 -2.21567
SOX9 SRY (sex determining region Y)-box 9 -2.19999
HOXA6 homeobox A6 -2.19602
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 -2.1928
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) -2.18691
CALM2 calmodulin 2 (phosphorylase kinase, delta) -2.18332
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -2.17996
PXDNL peroxidasin-like -2.15242
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase -2.13937
PYGL phosphorylase, glycogen, liver -2.13397
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -2.12126
HOXA10-HOXA9 HOXA10-HOXA9 readthrough -2.12024
CDK14 cyclin-dependent kinase 14 -2.12015
CENPE centromere protein E, 312kDa -2.10691
OPRPN opiorphin prepropeptide -2.08408
CRYZL1 crystallin, zeta (quinone reductase)-like 1 -2.08282
CX3CL1 chemokine (C-X3-C motif) ligand 1 -2.07634
WNT5A wingless-type MMTV integration site family, member 5A -2.05643
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase -2.04503
ESRRG estrogen-related receptor gamma -2.0445
TRIM56 tripartite motif containing 56 -2.04194
PDIA3 protein disulfide isomerase family A, member 3 -2.0277
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 -2.02312
ACSL6 acyl-CoA synthetase long-chain family member 6 -2.02302
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 -2.0175
VAV3 vav 3 guanine nucleotide exchange factor -2.01673
DYNC2I1 dynein 2 intermediate chain 1 -2.00752
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 -2.00611