CRCGN015_HEPG2_48H:F24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1h-1,2,3-benzotriazole 11.2 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

107 genes differentially expressed following the CRCGN015_HEPG2_48H:F24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 4.95284
CHN1 chimerin 1 4.81622
UBE2A ubiquitin-conjugating enzyme E2A 4.34084
TLR4 toll-like receptor 4 4.30825
EXOSC4 exosome component 4 4.00432
COQ8A coenzyme Q8A 3.64998
FZD7 frizzled class receptor 7 3.31241
CCNF cyclin F 3.21873
UBE2D1 ubiquitin-conjugating enzyme E2D 1 3.18345
CPPED1 calcineurin-like phosphoesterase domain containing 1 2.68775
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.68581
STX10 syntaxin 10 2.58626
WIF1 WNT inhibitory factor 1 2.32008
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 2.26101
MRPS31 mitochondrial ribosomal protein S31 2.25678
GATA2 GATA binding protein 2 2.22589
VTA1 vesicle (multivesicular body) trafficking 1 2.2218
FXR2 fragile X mental retardation, autosomal homolog 2 2.20781
RPS5 ribosomal protein S5 2.16037
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 2.14942
ENTR1 endosome associated trafficking regulator 1 2.12444
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 2.08102
FUCA1 fucosidase, alpha-L- 1, tissue 2.05677
MAP3K3 mitogen-activated protein kinase kinase kinase 3 2.04935
SP3 Sp3 transcription factor 2.0484
BCCIP BRCA2 and CDKN1A interacting protein 2.02748
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.02353
LOC114841035 uncharacterized LOC114841035 2.02343
SSNA1 Sjogren syndrome nuclear autoantigen 1 2.01803
RPS12 ribosomal protein S12 2.0087
METRN meteorin, glial cell differentiation regulator 2.00595
CRNKL1 crooked neck pre-mRNA splicing factor 1 2.00341

decreased expression

Symbol Name Standardized Value
MT1X metallothionein 1X -8.09148
CXADR coxsackie virus and adenovirus receptor -7.58082
TUBB6 tubulin, beta 6 class V -5.58075
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -5.17062
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -4.79803
PECR peroxisomal trans-2-enoyl-CoA reductase -4.61611
VDAC1 voltage-dependent anion channel 1 -4.53259
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.27727
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -4.01031
SLC35F2 solute carrier family 35, member F2 -3.77254
RAI14 retinoic acid induced 14 -3.04443
CSRP2 cysteine and glycine-rich protein 2 -3.03955
OSBPL10 oxysterol binding protein-like 10 -2.84238
HSF2BP heat shock transcription factor 2 binding protein -2.82044
TFRC transferrin receptor -2.6947
IGFBP7 insulin-like growth factor binding protein 7 -2.64164
TIMELESS timeless circadian clock -2.63718
LYRM9 LYR motif containing 9 -2.61071
HBZ hemoglobin, zeta -2.54847
ND5 NADH dehydrogenase subunit 5 -2.42462
HCAR3 hydroxycarboxylic acid receptor 3 -2.38239
MT1E metallothionein 1E -2.29095
WRN Werner syndrome, RecQ helicase-like -2.27463
CDC50B cell division cycle 50 P4-ATPase accessory subunit B -2.27139
XDH xanthine dehydrogenase -2.25199
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -2.23622
OPRK1 opioid receptor, kappa 1 -2.22995
TGM2 transglutaminase 2 -2.21973
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 -2.21484
GTF2A1 general transcription factor IIA, 1, 19/37kDa -2.19518
ATG10 autophagy related 10 -2.19092
GFI1B growth factor independent 1B transcription repressor -2.18589
MT1F metallothionein 1F -2.18399
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 -2.17167
PHC1 polyhomeotic homolog 1 (Drosophila) -2.17157
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 -2.15823
HESX1 HESX homeobox 1 -2.1573
ERMAP erythroblast membrane-associated protein (Scianna blood group) -2.15687
ACKR2 atypical chemokine receptor 2 -2.13934
BCL9 B-cell CLL/lymphoma 9 -2.13849
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -2.1376
TAGLN3 transgelin 3 -2.13468
EDA2R ectodysplasin A2 receptor -2.12746
CLDN1 claudin 1 -2.1194
SLC26A4 solute carrier family 26 (anion exchanger), member 4 -2.1178
RHAG Rh-associated glycoprotein -2.10643
ELAC1 elaC ribonuclease Z 1 -2.0954
ZBED2 zinc finger, BED-type containing 2 -2.09105
TFDP3 transcription factor Dp family, member 3 -2.09066
GYPB glycophorin B (MNS blood group) -2.08321
S100P S100 calcium binding protein P -2.08091
P2RY10 purinergic receptor P2Y, G-protein coupled, 10 -2.07746
RAB6B RAB6B, member RAS oncogene family -2.07388
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 -2.0725
TP53BP2 tumor protein p53 binding protein 2 -2.06381
TENM4 teneurin transmembrane protein 4 -2.05803
KLF1 Kruppel-like factor 1 (erythroid) -2.05607
BTG3 BTG family, member 3 -2.05461
TEX15 testis expressed 15 -2.04166
GPR50 G protein-coupled receptor 50 -2.0405
MAP9 microtubule-associated protein 9 -2.03712
LXN latexin -2.03671
HYDIN HYDIN, axonemal central pair apparatus protein -2.02826
NEFH neurofilament, heavy polypeptide -2.02611
NCS1 neuronal calcium sensor 1 -2.02537
RBMS2 RNA binding motif, single stranded interacting protein 2 -2.02444
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -2.02261
LAPTM4A lysosomal protein transmembrane 4 alpha -2.02128
GPR87 G protein-coupled receptor 87 -2.02072
PRSS23 protease, serine, 23 -2.01662
LOC128966601 pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial-like -2.01325
BMP3 bone morphogenetic protein 3 -2.01306
NEUROD6 neuronal differentiation 6 -2.01099
OR10C1 olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene) -2.0029
SULT4A1 sulfotransferase family 4A, member 1 -2.0021