CRCGN015_HEPG2_48H:G16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sirolimus 10.0 um perturbation at 48 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

112 genes differentially expressed following the CRCGN015_HEPG2_48H:G16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PLEKHJ1 pleckstrin homology domain containing, family J member 1 4.06662
HMGA2 high mobility group AT-hook 2 3.54475
FAT1 FAT atypical cadherin 1 3.42034
FHL2 four and a half LIM domains 2 3.24858
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.10256
ITGB5 integrin, beta 5 2.95136
EDN1 endothelin 1 2.79785
TMEM50A transmembrane protein 50A 2.77747
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.71111
SQOR sulfide quinone oxidoreductase 2.66243
TRIB1 tribbles pseudokinase 1 2.61944
BAMBI BMP and activin membrane-bound inhibitor 2.6191
SNRPE small nuclear ribonucleoprotein polypeptide E 2.59409
DUSP6 dual specificity phosphatase 6 2.52485
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.51965
PTPRM protein tyrosine phosphatase, receptor type, M 2.45504
ADSL adenylosuccinate lyase 2.45192
RGS4 regulator of G-protein signaling 4 2.4434
MMRN1 multimerin 1 2.39265
MAP2K5 mitogen-activated protein kinase kinase 5 2.35832
LGALS8 lectin, galactoside-binding, soluble, 8 2.31728
GRB10 growth factor receptor-bound protein 10 2.31524
CST1 cystatin SN 2.30509
MAPK13 mitogen-activated protein kinase 13 2.29261
TRIM6-TRIM34 TRIM6-TRIM34 readthrough 2.28691
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 2.24015
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2.23335
WNT6 wingless-type MMTV integration site family, member 6 2.14886
IL13RA1 interleukin 13 receptor, alpha 1 2.14781
GGT5 gamma-glutamyltransferase 5 2.143
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.11167
FOXC2 forkhead box C2 2.10334
TUBB6 tubulin, beta 6 class V 2.09132
CYFIP1 cytoplasmic FMR1 interacting protein 1 2.08966
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 2.083
RNF103-CHMP3 RNF103-CHMP3 readthrough 2.08171
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 2.06706
COL9A2 collagen, type IX, alpha 2 2.06335
NLRP4 NLR family, pyrin domain containing 4 2.06113
PCYOX1L prenylcysteine oxidase 1 like 2.04872
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2.04368
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 2.03172
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.0314
NGF nerve growth factor (beta polypeptide) 2.0259
PTCH2 patched 2 2.0173
ERN2 endoplasmic reticulum to nucleus signaling 2 2.01343
PRDM11 PR domain containing 11 2.00458

decreased expression

Symbol Name Standardized Value
RPS4Y1 ribosomal protein S4, Y-linked 1 -7.46541
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -4.27559
RHOB ras homolog family member B -3.92128
TM9SF3 transmembrane 9 superfamily member 3 -3.35992
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -3.18032
PHGDH phosphoglycerate dehydrogenase -2.99816
SNX6 sorting nexin 6 -2.95224
PGM1 phosphoglucomutase 1 -2.86884
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.84059
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.84029
ATG4A autophagy related 4A, cysteine peptidase -2.71519
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.61033
CCDC86 coiled-coil domain containing 86 -2.56689
MPC2 mitochondrial pyruvate carrier 2 -2.55802
VAV3 vav 3 guanine nucleotide exchange factor -2.53774
SCCPDH saccharopine dehydrogenase (putative) -2.4768
DHCR7 7-dehydrocholesterol reductase -2.46191
P4HB prolyl 4-hydroxylase, beta polypeptide -2.44941
APMAP adipocyte plasma membrane associated protein -2.44646
MARCHF5 membrane associated ring-CH-type finger 5 -2.43548
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.42176
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) -2.40413
PGC progastricsin (pepsinogen C) -2.39772
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.38921
PSAT1 phosphoserine aminotransferase 1 -2.38746
FOXK2 forkhead box K2 -2.3842
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -2.37431
S100P S100 calcium binding protein P -2.36806
FTL ferritin, light polypeptide -2.35456
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 -2.35416
RNF187 ring finger protein 187 -2.3526
HSPA4L heat shock 70kDa protein 4-like -2.3516
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 -2.29375
TRIB3 tribbles pseudokinase 3 -2.29182
KCTD2 potassium channel tetramerization domain containing 2 -2.29146
ACADSB acyl-CoA dehydrogenase, short/branched chain -2.2837
GFOD1 glucose-fructose oxidoreductase domain containing 1 -2.28075
SELENBP1 selenium binding protein 1 -2.27971
PAK1IP1 PAK1 interacting protein 1 -2.26198
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -2.23959
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.20126
ACO1 aconitase 1, soluble -2.19214
DCUN1D2 DCN1, defective in cullin neddylation 1, domain containing 2 -2.19123
TEX10 testis expressed 10 -2.18881
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) -2.18232
PCID2 PCI domain containing 2 -2.15414
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.14912
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.14578
NUCB2 nucleobindin 2 -2.13366
IP6K1 inositol hexakisphosphate kinase 1 -2.1232
PYCR1 pyrroline-5-carboxylate reductase 1 -2.12257
NIT1 nitrilase 1 -2.11684
HMOX1 heme oxygenase 1 -2.11292
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) -2.10189
MLF2 myeloid leukemia factor 2 -2.07398
MEN1 multiple endocrine neoplasia I -2.07207
THAP12 THAP domain containing 12 -2.06793
DHCR24 24-dehydrocholesterol reductase -2.06731
NUCB1 nucleobindin 1 -2.0562
MFAP4 microfibrillar-associated protein 4 -2.03583
ACAD8 acyl-CoA dehydrogenase family, member 8 -2.0348
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -2.03417
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.02793
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.01594
VSIG2 V-set and immunoglobulin domain containing 2 -2.01166