CRCGN015_HEPG2_48H:G17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sirolimus 3.33 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN015_HEPG2_48H:G17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 4.12875
MAMLD1 mastermind-like domain containing 1 4.01704
CHMP6 charged multivesicular body protein 6 3.48428
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 3.15566
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 3.03508
HMGA2 high mobility group AT-hook 2 2.93343
ITGB5 integrin, beta 5 2.89797
CCNF cyclin F 2.7537
CCND1 cyclin D1 2.75083
TRIB1 tribbles pseudokinase 1 2.71634
NECTIN2 nectin cell adhesion molecule 2 2.59822
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 2.42595
TMEM50A transmembrane protein 50A 2.42164
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.37791
HMGB3 high mobility group box 3 2.35961
ZMIZ1 zinc finger, MIZ-type containing 1 2.34101
BMP4 bone morphogenetic protein 4 2.33713
LGALS8 lectin, galactoside-binding, soluble, 8 2.27672
MYL9 myosin, light chain 9, regulatory 2.27316
DDB2 damage-specific DNA binding protein 2, 48kDa 2.181
KIF11 kinesin family member 11 2.1316
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 2.12183
CKAP5 cytoskeleton associated protein 5 2.10864
RASSF4 Ras association (RalGDS/AF-6) domain family member 4 2.09829
KIFC3 kinesin family member C3 2.07143
IL13RA1 interleukin 13 receptor, alpha 1 2.04677
ARHGAP5 Rho GTPase activating protein 5 2.04646
KIF18B kinesin family member 18B 2.03886
NGF nerve growth factor (beta polypeptide) 2.01648
HIP1R huntingtin interacting protein 1 related 2.00956
STMN1 stathmin 1 2.00556
IGFBP4 insulin-like growth factor binding protein 4 2.00335

decreased expression

Symbol Name Standardized Value
PDLIM1 PDZ and LIM domain 1 -3.96694
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -3.43273
PGM1 phosphoglucomutase 1 -2.84829
VAV3 vav 3 guanine nucleotide exchange factor -2.62981
MPC2 mitochondrial pyruvate carrier 2 -2.55825
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.49052
GFOD1 glucose-fructose oxidoreductase domain containing 1 -2.4843
ALDOC aldolase C, fructose-bisphosphate -2.32779
MOCS2 molybdenum cofactor synthesis 2 -2.28344
CDC40 cell division cycle 40 -2.14526
PCDH17 protocadherin 17 -2.08597
TRIM37 tripartite motif containing 37 -2.0568
NME1 NME/NM23 nucleoside diphosphate kinase 1 -2.05182
MFAP1 microfibrillar-associated protein 1 -2.04569
LRRC47 leucine rich repeat containing 47 -2.01763
DDIT4 DNA-damage-inducible transcript 4 -2.01361
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 -2.00703
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.00479