CRCGN015_HEPG2_48H:G18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sirolimus 1.11 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN015_HEPG2_48H:G18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 3.08974
LCN2 lipocalin 2 3.07662
IGFBP3 insulin-like growth factor binding protein 3 2.95726
BMP4 bone morphogenetic protein 4 2.6435
KIF5C kinesin family member 5C 2.62903
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.62479
SCRN1 secernin 1 2.5955
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.4764
KNTC1 kinetochore associated 1 2.45448
NLRP4 NLR family, pyrin domain containing 4 2.4497
BAMBI BMP and activin membrane-bound inhibitor 2.38875
FAT1 FAT atypical cadherin 1 2.3536
ITGB5 integrin, beta 5 2.29443
PDZK1IP1 PDZK1 interacting protein 1 2.28255
IL13RA1 interleukin 13 receptor, alpha 1 2.23827
IRF2 interferon regulatory factor 2 2.1983
TMEM50A transmembrane protein 50A 2.16078
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) 2.15326
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 2.09508
RNPEP arginyl aminopeptidase (aminopeptidase B) 2.08059
ZMIZ1 zinc finger, MIZ-type containing 1 2.05853
DUOX2 dual oxidase 2 2.01642

decreased expression

Symbol Name Standardized Value
RPS4Y1 ribosomal protein S4, Y-linked 1 -4.54181
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.96595
MACF1 microtubule-actin crosslinking factor 1 -2.73537
FASTKD5 FAST kinase domains 5 -2.66711
HSPA4L heat shock 70kDa protein 4-like -2.62175
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.48159
GP1BA glycoprotein Ib (platelet), alpha polypeptide -2.46046
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.44087
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.43954
PGM1 phosphoglucomutase 1 -2.43936
ZSCAN5A zinc finger and SCAN domain containing 5A -2.42959
GALNS galactosamine (N-acetyl)-6-sulfatase -2.36578
POLR2H polymerase (RNA) II (DNA directed) polypeptide H -2.30463
LAP3 leucine aminopeptidase 3 -2.29769
NELFE negative elongation factor complex member E -2.27987
IFT46 intraflagellar transport 46 -2.21045
POMT2 protein-O-mannosyltransferase 2 -2.13387
TFRC transferrin receptor -2.11148
CDK7 cyclin-dependent kinase 7 -2.10592
GFOD1 glucose-fructose oxidoreductase domain containing 1 -2.10211
NMD3 NMD3 ribosome export adaptor -2.10189
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.08459
MPC2 mitochondrial pyruvate carrier 2 -2.08375
IFT88 intraflagellar transport 88 -2.08271
BUD31 BUD31 homolog (S. cerevisiae) -2.08184
PHGDH phosphoglycerate dehydrogenase -2.0735
BCL2A1 BCL2-related protein A1 -2.061
NXT1 nuclear transport factor 2-like export factor 1 -2.05727
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit -2.04822
EFCAB6 EF-hand calcium binding domain 6 -2.04743
CCDC86 coiled-coil domain containing 86 -2.04503
DNAH7 dynein, axonemal, heavy chain 7 -2.04327
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.02637
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 -2.00785
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.00066