CRCGN015_HEPG2_48H:G19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dinitrotoluene 99.01 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

334 genes differentially expressed following the CRCGN015_HEPG2_48H:G19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 5.39085
DENND2D DENN/MADD domain containing 2D 5.33625
AMDHD2 amidohydrolase domain containing 2 4.99905
STAP2 signal transducing adaptor family member 2 4.7028
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 4.53615
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 4.49265
BAD BCL2-associated agonist of cell death 4.49218
UBE2A ubiquitin-conjugating enzyme E2A 4.38765
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 4.11675
SCT secretin 3.9781
PLSCR3 phospholipid scramblase 3 3.91178
MNMIP1 manchette microtubule inner protein 1 3.8495
ICAM3 intercellular adhesion molecule 3 3.82625
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 3.7048
EMID1 EMI domain containing 1 3.6419
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 3.59785
CEP131 centrosomal protein 131kDa 3.5594
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 3.46545
REM1 RAS (RAD and GEM)-like GTP-binding 1 3.26295
PRH1 proline-rich protein HaeIII subfamily 1 3.2227
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 3.21635
GNL1 guanine nucleotide binding protein-like 1 3.1848
PRRX1 paired related homeobox 1 3.1753
DSPP dentin sialophosphoprotein 3.1488
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 3.1235
EXD3 exonuclease 3'-5' domain containing 3 3.11825
FSD1 fibronectin type III and SPRY domain containing 1 3.11445
ZNF219 zinc finger protein 219 3.10975
NKRF NFKB repressing factor 3.10425
KRT3 keratin 3, type II 3.0817
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 3.07185
AVPR1B arginine vasopressin receptor 1B 3.0679
CBARP CACN subunit beta associated regulatory protein 3.06555
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 3.00515
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.9909
WDR77 WD repeat domain 77 2.98887
TLE6 transducin-like enhancer of split 6 2.96795
ROM1 retinal outer segment membrane protein 1 2.9641
KRT33A keratin 33A, type I 2.90705
ETAA1 Ewing tumor-associated antigen 1 2.89985
ADRA2C adrenoceptor alpha 2C 2.8755
VSX1 visual system homeobox 1 2.8669
ADGRB1 adhesion G protein-coupled receptor B1 2.85235
DMBT1 deleted in malignant brain tumors 1 2.851
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 2.8456
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 2.7893
MYBBP1A MYB binding protein (P160) 1a 2.7757
VRTN vertebrae development associated 2.7715
TGIF2 TGFB-induced factor homeobox 2 2.76162
KIF25 kinesin family member 25 2.75618
IMPG2 interphotoreceptor matrix proteoglycan 2 2.739
LCN1 lipocalin 1 2.7374
WDR4 WD repeat domain 4 2.72965
ZNF205 zinc finger protein 205 2.7199
ZNF821 zinc finger protein 821 2.71788
POGLUT2 protein O-glucosyltransferase 2 2.71425
DNASE1 deoxyribonuclease I 2.71045
MORN1 MORN repeat containing 1 2.70225
MYH13 myosin, heavy chain 13, skeletal muscle 2.69835
VCX3A variable charge, X-linked 3A 2.6884
RAMP1 receptor (G protein-coupled) activity modifying protein 1 2.68795
DUX4 double homeobox 4 2.6803
ZSCAN2 zinc finger and SCAN domain containing 2 2.6683
MMP26 matrix metallopeptidase 26 2.65895
GUCA1B guanylate cyclase activator 1B (retina) 2.6588
GPALPP1 GPALPP motifs containing 1 2.65585
NKX6-1 NK6 homeobox 1 2.6506
CATSPERH catsper channel auxiliary subunit eta 2.6434
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.63715
RHBG Rh family, B glycoprotein (gene/pseudogene) 2.6348
AIRE autoimmune regulator 2.6266
TP53TG5 TP53 target 5 2.6216
ATOX1 antioxidant 1 copper chaperone 2.61175
DOC2B double C2-like domains, beta 2.6101
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.59855
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 2.5903
PSPN persephin 2.5861
SSTR5 somatostatin receptor 5 2.58315
CCDC170 coiled-coil domain containing 170 2.58005
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 2.5796
CYREN cell cycle regulator of NHEJ 2.56895
PTP4A3 protein tyrosine phosphatase type IVA, member 3 2.5689
MAPK4 mitogen-activated protein kinase 4 2.56225
DUS2 dihydrouridine synthase 2 2.55697
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 2.5395
FOXL2 forkhead box L2 2.5336
DEF6 differentially expressed in FDCP 6 homolog (mouse) 2.53195
IFNGR1 interferon gamma receptor 1 2.52755
PRDM11 PR domain containing 11 2.51125
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 2.5048
SDK2 sidekick cell adhesion molecule 2 2.4949
HSFX2 heat shock transcription factor family, X linked 2 2.4863
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 2.48505
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B 2.4826
CRH corticotropin releasing hormone 2.48187
NEU2 sialidase 2 (cytosolic sialidase) 2.4796
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 2.4788
PSKH1 protein serine kinase H1 2.47815
MSX1 msh homeobox 1 2.4639
ZNF696 zinc finger protein 696 2.46365
OXLD1 oxidoreductase-like domain containing 1 2.45845
TAAR5 trace amine associated receptor 5 2.4546
DNAH9 dynein, axonemal, heavy chain 9 2.44815
VAMP5 vesicle-associated membrane protein 5 2.44775
HAND2 heart and neural crest derivatives expressed 2 2.44475
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 2.44215
APOA4 apolipoprotein A-IV 2.4309
LOC124907090 ankyrin repeat domain-containing protein SOWAHC-like 2.41825
MUC7 mucin 7, secreted 2.4085
KRT36 keratin 36, type I 2.40575
TRPC6 transient receptor potential cation channel, subfamily C, member 6 2.40197
ZNRF4 zinc and ring finger 4 2.4
GDF7 growth differentiation factor 7 2.3982
IGF1R insulin-like growth factor 1 receptor 2.39785
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.39735
OR10H1 olfactory receptor, family 10, subfamily H, member 1 2.3849
EFNB3 ephrin-B3 2.38442
MATN1 matrilin 1, cartilage matrix protein 2.38242
PRB3 proline-rich protein BstNI subfamily 3 2.37895
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 2.37805
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.3746
PCSK5 proprotein convertase subtilisin/kexin type 5 2.37325
INKA2 inka box actin regulator 2 2.36785
DLX6 distal-less homeobox 6 2.36175
IFT81 intraflagellar transport 81 2.36105
MTNAP1 mitochondrial nucleoid associated protein 1 2.3582
CLDN15 claudin 15 2.34465
NGB neuroglobin 2.3414
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 2.33925
PCYT1B phosphate cytidylyltransferase 1, choline, beta 2.33705
FIP1L1 factor interacting with PAPOLA and CPSF1 2.33535
POLR2G polymerase (RNA) II (DNA directed) polypeptide G 2.33175
SOX15 SRY (sex determining region Y)-box 15 2.3286
EVA1B eva-1 homolog B (C. elegans) 2.3261
SPATA31A3 SPATA31 subfamily A, member 3 2.3251
CYTH3 cytohesin 3 2.3201
TRMT61A tRNA methyltransferase 61A 2.32008
CORO7-PAM16 CORO7-PAM16 readthrough 2.31675
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 2.3145
AMN amnion associated transmembrane protein 2.3124
EXOSC4 exosome component 4 2.31128
B3GAT3 beta-1,3-glucuronyltransferase 3 2.30623
GJA3 gap junction protein, alpha 3, 46kDa 2.30475
ALOX12B arachidonate 12-lipoxygenase, 12R type 2.30015
PHOX2B paired-like homeobox 2b 2.3001
PLA2G3 phospholipase A2, group III 2.29955
PHF13 PHD finger protein 13 2.29545
GPR45 G protein-coupled receptor 45 2.2946
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 2.29305
FABP2 fatty acid binding protein 2, intestinal 2.28905
ADORA3 adenosine A3 receptor 2.27595
NKX2-8 NK2 homeobox 8 2.26295
AP5S1 adaptor-related protein complex 5, sigma 1 subunit 2.2628
CRX cone-rod homeobox 2.25885
FGF8 fibroblast growth factor 8 (androgen-induced) 2.25815
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.25605
HNF1A HNF1 homeobox A 2.25567
PALB2 partner and localizer of BRCA2 2.25395
PRB2 proline-rich protein BstNI subfamily 2 2.25157
RFXANK regulatory factor X-associated ankyrin-containing protein 2.25075
ZNF516 zinc finger protein 516 2.2504
NTSR1 neurotensin receptor 1 (high affinity) 2.2494
TMEM143 transmembrane protein 143 2.2399
EMX2 empty spiracles homeobox 2 2.2381
EVC Ellis van Creveld protein 2.23415
PKD2L1 polycystic kidney disease 2-like 1 2.23305
KIAA1614 KIAA1614 2.2317
TMEM258 transmembrane protein 258 2.2296
FABP4 fatty acid binding protein 4, adipocyte 2.2291
MAPKAP1 mitogen-activated protein kinase associated protein 1 2.22865
HOXD12 homeobox D12 2.22525
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 2.22353
RFXAP regulatory factor X-associated protein 2.22305
SORBS1 sorbin and SH3 domain containing 1 2.21635
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) 2.211
GALR2 galanin receptor 2 2.2046
FRAS1 Fraser extracellular matrix complex subunit 1 2.19705
CD5 CD5 molecule 2.19265
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 2.1916
CTSF cathepsin F 2.18925
GRK1 G protein-coupled receptor kinase 1 2.1889
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 2.1883
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.18755
HOXD9 homeobox D9 2.1875
POU2F2 POU class 2 homeobox 2 2.17788
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 2.17646
CFAP410 cilia and flagella associated protein 410 2.17485
PICK1 protein interacting with PRKCA 1 2.1746
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.1745
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 2.1722
DCAKD dephospho-CoA kinase domain containing 2.16775
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound 2.16683
POU3F4 POU class 3 homeobox 4 2.16405
SOX17 SRY (sex determining region Y)-box 17 2.1635
CRYBB1 crystallin, beta B1 2.1624
CCL24 chemokine (C-C motif) ligand 24 2.1623
OPRD1 opioid receptor, delta 1 2.16125
CD180 CD180 molecule 2.1586
HMX1 H6 family homeobox 1 2.15235
SAMD14 sterile alpha motif domain containing 14 2.152
TSPAN9 tetraspanin 9 2.1501
HDAC11 histone deacetylase 11 2.1439
JRKL JRK-like 2.1424
IL12RB1 interleukin 12 receptor, beta 1 2.1421
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.14125
HSPB2 heat shock 27kDa protein 2 2.14005
MMP17 matrix metallopeptidase 17 (membrane-inserted) 2.13775
FAAP24 FA core complex associated protein 24 2.1376
SERF1A small EDRK-rich factor 1A (telomeric) 2.1345
INSL6 insulin-like 6 2.1342
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 2.13345
IQCC IQ motif containing C 2.1334
POMT2 protein-O-mannosyltransferase 2 2.13325
TADA2A transcriptional adaptor 2A 2.12988
SHH sonic hedgehog 2.1293
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 2.128
LHX6 LIM homeobox 6 2.1266
BIRC7 baculoviral IAP repeat containing 7 2.1258
ERN2 endoplasmic reticulum to nucleus signaling 2 2.1245
CES3 carboxylesterase 3 2.12435
A4GALT alpha 1,4-galactosyltransferase 2.121
NMUR1 neuromedin U receptor 1 2.1188
IKZF4 IKAROS family zinc finger 4 (Eos) 2.11385
RNF113A ring finger protein 113A 2.1123
PTCRA pre T-cell antigen receptor alpha 2.11043
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial 2.10775
EGFL6 EGF-like-domain, multiple 6 2.10295
BRMS1L breast cancer metastasis-suppressor 1-like 2.1025
ZBTB14 zinc finger and BTB domain containing 14 2.10245
KRT83 keratin 83, type II 2.1019
PDCD1 programmed cell death 1 2.1011
GFER growth factor, augmenter of liver regeneration 2.09975
SSTR3 somatostatin receptor 3 2.0965
EPCIP exosomal polycystin 1 interacting protein 2.09315
ZSCAN16 zinc finger and SCAN domain containing 16 2.0928
SETMAR SET domain and mariner transposase fusion gene 2.0928
CRYGC crystallin, gamma C 2.09215
ST14 suppression of tumorigenicity 14 (colon carcinoma) 2.07805
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.07485
DCTPP1 dCTP pyrophosphatase 1 2.07405
LOC124907012 endogenous retrovirus group K member 7 Env polyprotein-like 2.0734
P3H3 prolyl 3-hydroxylase 3 2.06805
PTGDR2 prostaglandin D2 receptor 2 2.06643
NEUROG1 neurogenin 1 2.065
SHANK1 SH3 and multiple ankyrin repeat domains 1 2.06173
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 2.05975
PRB4 proline-rich protein BstNI subfamily 4 2.05725
LHX5 LIM homeobox 5 2.0565
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 2.0562
RBP3 retinol binding protein 3, interstitial 2.0496
MYO1A myosin IA 2.04845
ZSCAN5A zinc finger and SCAN domain containing 5A 2.04805
CASP6 caspase 6, apoptosis-related cysteine peptidase 2.0475
BARX2 BARX homeobox 2 2.04565
CNGB1 cyclic nucleotide gated channel beta 1 2.04508
MATN4 matrilin 4 2.04425
PDCL phosducin-like 2.04243
NEUROG3 neurogenin 3 2.04155
GMIP GEM interacting protein 2.04155
GFAP glial fibrillary acidic protein 2.04152
TULP4 tubby like protein 4 2.03925
THAP3 THAP domain containing, apoptosis associated protein 3 2.0374
ITPKA inositol-trisphosphate 3-kinase A 2.03615
CHI3L2 chitinase 3-like 2 2.0361
ACTR8 ARP8 actin-related protein 8 homolog (yeast) 2.03605
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 2.0354
CCIN calicin 2.0326
KLHL36 kelch-like family member 36 2.0316
MYH14 myosin, heavy chain 14, non-muscle 2.03013
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 2.03
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.02925
POPDC2 popeye domain containing 2 2.0235
CERS4 ceramide synthase 4 2.0198
POU4F1 POU class 4 homeobox 1 2.01852
PCDHGA11 protocadherin gamma subfamily A, 11 2.0185
DIO3 deiodinase, iodothyronine, type III 2.0168
URM1 ubiquitin related modifier 1 2.01675
SGF29 SAGA complex associated factor 29 2.0157
SYNDIG1 synapse differentiation inducing 1 2.01425
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3 2.01213
CRYBA4 crystallin, beta A4 2.01205
ANGPT4 angiopoietin 4 2.01155
SLCO5A1 solute carrier organic anion transporter family, member 5A1 2.00965
CDK2 cyclin-dependent kinase 2 2.009
MFAP2 microfibrillar-associated protein 2 2.0073
SYK spleen tyrosine kinase 2.0065
DEF8 differentially expressed in FDCP 8 homolog (mouse) 2.00545
VEGFB vascular endothelial growth factor B 2.0034
ZNF107 zinc finger protein 107 2.00205
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 2.00105

decreased expression

Symbol Name Standardized Value
HPRT1 hypoxanthine phosphoribosyltransferase 1 -9.27695
TM9SF3 transmembrane 9 superfamily member 3 -6.3164
PCCB propionyl CoA carboxylase, beta polypeptide -5.40435
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -4.9313
S100P S100 calcium binding protein P -4.66275
PDLIM1 PDZ and LIM domain 1 -4.4928
PECR peroxisomal trans-2-enoyl-CoA reductase -4.28765
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -4.12235
MT1X metallothionein 1X -4.01102
FOXJ3 forkhead box J3 -3.89205
PROM1 prominin 1 -3.32265
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.2507
RAB4A RAB4A, member RAS oncogene family -2.9785
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -2.76675
STEAP3 STEAP family member 3, metalloreductase -2.6979
MEAF6 MYST/Esa1-associated factor 6 -2.60295
HBEGF heparin-binding EGF-like growth factor -2.56787
FBXL12 F-box and leucine-rich repeat protein 12 -2.5555
APOH apolipoprotein H (beta-2-glycoprotein I) -2.5392
NPDC1 neural proliferation, differentiation and control, 1 -2.51055
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 -2.49035
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 -2.4472
NEFH neurofilament, heavy polypeptide -2.33985
TENM1 teneurin transmembrane protein 1 -2.2688
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.25358
PLD3 phospholipase D family, member 3 -2.253
CD82 CD82 molecule -2.24855
CPEB3 cytoplasmic polyadenylation element binding protein 3 -2.23835
ZDHHC7 zinc finger, DHHC-type containing 7 -2.2004
KIFC3 kinesin family member C3 -2.1909
GSE1 Gse1 coiled-coil protein -2.17558
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa -2.15795
SPATA20 spermatogenesis associated 20 -2.1433
CTSB cathepsin B -2.1309
ACTMAP actin maturation protease -2.12915
LRRC8D leucine rich repeat containing 8 family, member D -2.10365
MRPS10 mitochondrial ribosomal protein S10 -2.08705
HEXB hexosaminidase B (beta polypeptide) -2.0811
PRPF3 pre-mRNA processing factor 3 -2.06825
LAPTM4A lysosomal protein transmembrane 4 alpha -2.04795
PLXNB2 plexin B2 -2.02295
SARAF store-operated calcium entry-associated regulatory factor -2.0214
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa -2.01535
MOAP1 modulator of apoptosis 1 -2.0056