CRCGN015_HEPG2_48H:G20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dinitrotoluene 33.0 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

163 genes differentially expressed following the CRCGN015_HEPG2_48H:G20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FZD7 frizzled class receptor 7 5.50065
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 5.03934
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 4.82598
TNIP1 TNFAIP3 interacting protein 1 4.73951
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.44337
BACE2 beta-site APP-cleaving enzyme 2 3.88633
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.66712
EXOSC4 exosome component 4 3.63601
FCHO1 FCH domain only 1 3.63169
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 3.51043
METRN meteorin, glial cell differentiation regulator 3.4941
PPOX protoporphyrinogen oxidase 3.33996
MAST2 microtubule associated serine/threonine kinase 2 3.33694
MRPL16 mitochondrial ribosomal protein L16 3.17031
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 2.76109
SLC66A2 solute carrier family 66 member 2 2.71446
MRM2 mitochondrial rRNA methyltransferase 2 2.70202
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.6373
SRRD SRR1 domain containing 2.5895
SFRP4 secreted frizzled-related protein 4 2.55493
EIF3I eukaryotic translation initiation factor 3, subunit I 2.53948
EPS8 epidermal growth factor receptor pathway substrate 8 2.52795
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 2.48649
POLR2F polymerase (RNA) II (DNA directed) polypeptide F 2.4656
STX18 syntaxin 18 2.44106
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.41471
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa 2.41172
UIMC1 ubiquitin interaction motif containing 1 2.402
CPZ carboxypeptidase Z 2.34886
TRIT1 tRNA isopentenyltransferase 1 2.33577
WIPI2 WD repeat domain, phosphoinositide interacting 2 2.32412
BIN3 bridging integrator 3 2.32386
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 2.30634
TMEM101 transmembrane protein 101 2.28535
PRPS2 phosphoribosyl pyrophosphate synthetase 2 2.27762
COMP cartilage oligomeric matrix protein 2.27715
ZCCHC24 zinc finger, CCHC domain containing 24 2.26117
PLPP1 phospholipid phosphatase 1 2.25255
CCDC69 coiled-coil domain containing 69 2.25103
RAB25 RAB25, member RAS oncogene family 2.23392
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2 2.23211
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 2.20688
ISLR immunoglobulin superfamily containing leucine-rich repeat 2.20504
KRCC1 lysine-rich coiled-coil 1 2.1988
TREM1 triggering receptor expressed on myeloid cells 1 2.17254
KLHL7 kelch-like family member 7 2.1721
RAP1A RAP1A, member of RAS oncogene family 2.17073
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 2.16558
GARS1 glycyl-tRNA synthetase 1 2.16496
SPINK1 serine peptidase inhibitor, Kazal type 1 2.16011
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 2.14131
VTA1 vesicle (multivesicular body) trafficking 1 2.13981
PIAS3 protein inhibitor of activated STAT, 3 2.13853
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 2.12982
HEBP2 heme binding protein 2 2.10702
SFRP1 secreted frizzled-related protein 1 2.10561
MPST mercaptopyruvate sulfurtransferase 2.10511
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 2.09348
TMEM160 transmembrane protein 160 2.08789
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 2.08783
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.05657
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 2.04005
CUTC cutC copper transporter 2.03051
BUD23 BUD23 rRNA methyltransferase and ribosome maturation factor 2.02598
RUVBL2 RuvB-like AAA ATPase 2 2.02473
ARF5 ADP-ribosylation factor 5 2.02341
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) 2.01418
ASCC2 activating signal cointegrator 1 complex subunit 2 2.01302
OSR2 odd-skipped related transciption factor 2 2.01135
RBM10 RNA binding motif protein 10 2.00404

decreased expression

Symbol Name Standardized Value
HSPA8 heat shock 70kDa protein 8 -5.0415
SYPL1 synaptophysin-like 1 -4.922
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -4.91908
CXADR coxsackie virus and adenovirus receptor -4.83866
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -4.66234
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.48553
BIRC2 baculoviral IAP repeat containing 2 -4.3595
PECR peroxisomal trans-2-enoyl-CoA reductase -4.08718
STAT1 signal transducer and activator of transcription 1, 91kDa -4.00433
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.652
NGRN neugrin, neurite outgrowth associated -3.54713
COG2 component of oligomeric golgi complex 2 -3.51704
MSMO1 methylsterol monooxygenase 1 -3.16082
RNF167 ring finger protein 167 -3.13431
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 -2.97197
LCK LCK proto-oncogene, Src family tyrosine kinase -2.85124
IL13RA1 interleukin 13 receptor, alpha 1 -2.76978
IFI44 interferon-induced protein 44 -2.76614
FADS2 fatty acid desaturase 2 -2.75669
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 -2.70614
ARHGAP33 Rho GTPase activating protein 33 -2.59843
TMEM164 transmembrane protein 164 -2.52973
FEV FEV (ETS oncogene family) -2.51065
NOCT nocturnin -2.5075
IFI44L interferon-induced protein 44-like -2.49845
ERV3-1-ZNF117 ERV3-1-ZNF117 readthrough -2.47102
SPRR1B small proline-rich protein 1B -2.4639
HMBOX1 homeobox containing 1 -2.44888
RHOB ras homolog family member B -2.4402
IFI27 interferon, alpha-inducible protein 27 -2.43866
TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough -2.42859
PROZ protein Z, vitamin K-dependent plasma glycoprotein -2.41161
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.38838
SV2A synaptic vesicle glycoprotein 2A -2.38482
NOL9 nucleolar protein 9 -2.38457
PRKCQ protein kinase C, theta -2.38063
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -2.36413
GSTA4 glutathione S-transferase alpha 4 -2.35395
EFNB1 ephrin-B1 -2.31124
IL36G interleukin 36, gamma -2.30521
NELL2 NEL-like 2 (chicken) -2.28772
TFRC transferrin receptor -2.27512
LAMP3 lysosomal-associated membrane protein 3 -2.27299
ZNF345 zinc finger protein 345 -2.26194
KRT6A keratin 6A, type II -2.25729
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.25089
XAF1 XIAP associated factor 1 -2.2379
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -2.2056
MCOLN3 mucolipin 3 -2.19687
SOSTDC1 sclerostin domain containing 1 -2.18669
TACR2 tachykinin receptor 2 -2.18414
PROX1 prospero homeobox 1 -2.18375
CCNK cyclin K -2.1736
RBM41 RNA binding motif protein 41 -2.17006
CCDC15 coiled-coil domain containing 15 -2.16759
FKTN fukutin -2.16743
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -2.16185
TEX10 testis expressed 10 -2.15471
BIRC3 baculoviral IAP repeat containing 3 -2.15198
GSK3B glycogen synthase kinase 3 beta -2.14793
HSPH1 heat shock 105kDa/110kDa protein 1 -2.14604
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 -2.1436
SPRR1A small proline-rich protein 1A -2.14185
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) -2.13703
GPSM3 G-protein signaling modulator 3 -2.13583
GBP1 guanylate binding protein 1, interferon-inducible -2.13381
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) -2.13357
IL12RB2 interleukin 12 receptor, beta 2 -2.11977
ITGA1 integrin, alpha 1 -2.10731
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 -2.09917
NCKAP1 NCK-associated protein 1 -2.09639
CXCL11 chemokine (C-X-C motif) ligand 11 -2.09402
FAR2 fatty acyl CoA reductase 2 -2.09358
CPNE7 copine VII -2.08227
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa -2.08059
FGFBP1 fibroblast growth factor binding protein 1 -2.07437
LPAR3 lysophosphatidic acid receptor 3 -2.073
PTPN7 protein tyrosine phosphatase, non-receptor type 7 -2.06022
WNT8B wingless-type MMTV integration site family, member 8B -2.05657
LIMA1 LIM domain and actin binding 1 -2.05506
NOX4 NADPH oxidase 4 -2.05026
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -2.0438
SOAT2 sterol O-acyltransferase 2 -2.0427
UBA7 ubiquitin-like modifier activating enzyme 7 -2.04171
RABEP1 rabaptin, RAB GTPase binding effector protein 1 -2.0385
ABITRAM actin binding transcription modulator -2.03618
EDAR ectodysplasin A receptor -2.03097
TDO2 tryptophan 2,3-dioxygenase -2.02595
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -2.02463
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.01564
RBBP9 retinoblastoma binding protein 9 -2.01116
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -2.00392
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -2.002