CRCGN015_HEPG2_48H:G23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,8-dihydroxy-2-quinolinecarboxylic acid 33.29 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

30 genes differentially expressed following the CRCGN015_HEPG2_48H:G23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5.01566
PRKCQ protein kinase C, theta 5.0014
MEF2C myocyte enhancer factor 2C 4.29521
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 4.09621
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.40169
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 2.83481
MYL11 myosin light chain 11 2.44657
SNX11 sorting nexin 11 2.36828
TNNI1 troponin I type 1 (skeletal, slow) 2.33987
RASL10A RAS-like, family 10, member A 2.28693
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 2.24672
MAMLD1 mastermind-like domain containing 1 2.21068
DDN dendrin 2.15995
TIPRL TOR signaling pathway regulator 2.06756
TBPL1 TBP-like 1 2.06191

decreased expression

Symbol Name Standardized Value
VDAC1 voltage-dependent anion channel 1 -4.87839
TM9SF3 transmembrane 9 superfamily member 3 -4.87569
PLIN2 perilipin 2 -3.47367
LDHD lactate dehydrogenase D -2.83461
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.71983
S100P S100 calcium binding protein P -2.71983
HEBP1 heme binding protein 1 -2.59457
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.47108
NLGN4X neuroligin 4, X-linked -2.19451
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) -2.15635
GPR137B G protein-coupled receptor 137B -2.1261
ARF5 ADP-ribosylation factor 5 -2.10743
TJP2 tight junction protein 2 -2.08162
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) -2.07251
TRIM13 tripartite motif containing 13 -2.06782