CRCGN015_HEPG2_48H:H16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-(chloromethyl)pyridine.hcl 99.45 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

127 genes differentially expressed following the CRCGN015_HEPG2_48H:H16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 3.59075
CNPY3 canopy FGF signaling regulator 3 3.38998
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.35295
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.08651
CCND1 cyclin D1 3.07231
ITGB5 integrin, beta 5 3.03157
PLAG1 pleiomorphic adenoma gene 1 2.97527
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.96949
TMEM50A transmembrane protein 50A 2.81192
DUSP6 dual specificity phosphatase 6 2.76424
STMN1 stathmin 1 2.73832
SIDT1 SID1 transmembrane family, member 1 2.69829
INF2 inverted formin, FH2 and WH2 domain containing 2.67911
ADRB2 adrenoceptor beta 2, surface 2.65617
CD8A CD8a molecule 2.64175
PHLDA2 pleckstrin homology-like domain, family A, member 2 2.63957
TMEM80 transmembrane protein 80 2.63732
RIPOR2 RHO family interacting cell polarization regulator 2 2.62306
PRKCD protein kinase C, delta 2.61786
POLR2M polymerase (RNA) II (DNA directed) polypeptide M 2.58863
SYPL1 synaptophysin-like 1 2.58344
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.54104
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.50847
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 2.47019
VASP vasodilator-stimulated phosphoprotein 2.43377
NUSAP1 nucleolar and spindle associated protein 1 2.43304
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 2.43091
FOSL1 FOS-like antigen 1 2.4236
LSR lipolysis stimulated lipoprotein receptor 2.39682
TIPRL TOR signaling pathway regulator 2.37803
LGALS8 lectin, galactoside-binding, soluble, 8 2.34945
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 2.33666
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.3345
DHPS deoxyhypusine synthase 2.29748
PTER phosphotriesterase related 2.2901
CNRIP1 cannabinoid receptor interacting protein 1 2.24605
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.244
TRIB1 tribbles pseudokinase 1 2.23994
FAT1 FAT atypical cadherin 1 2.23762
CD3E CD3e molecule, epsilon (CD3-TCR complex) 2.23152
TRIM66 tripartite motif containing 66 2.21614
BZW2 basic leucine zipper and W2 domains 2 2.18304
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 2.17374
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 2.16875
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2.16179
ITK IL2-inducible T-cell kinase 2.13087
SMTN smoothelin 2.12916
CCDC88C coiled-coil domain containing 88C 2.12739
EGR3 early growth response 3 2.11969
ANKRD36C ankyrin repeat domain 36C 2.0978
MINDY3 MINDY lysine 48 deubiquitinase 3 2.08984
UBE2W ubiquitin-conjugating enzyme E2W (putative) 2.08457
STK38L serine/threonine kinase 38 like 2.07004
HMGB3 high mobility group box 3 2.06557
ERCC2 excision repair cross-complementation group 2 2.0622
TRIM6-TRIM34 TRIM6-TRIM34 readthrough 2.06081
CAPNS1 calpain, small subunit 1 2.05541
GPR88 G protein-coupled receptor 88 2.04964
DBN1 drebrin 1 2.03931
BICRAL BICRA like chromatin remodeling complex associated protein 2.03832
ACAD10 acyl-CoA dehydrogenase family, member 10 2.03798
IRF2 interferon regulatory factor 2 2.0372
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 2.03572
GZMK granzyme K (granzyme 3; tryptase II) 2.03043
ANKRD28 ankyrin repeat domain 28 2.02936
MYBPH myosin binding protein H 2.02585
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 2.02307
SYNGAP1 synaptic Ras GTPase activating protein 1 2.01448

decreased expression

Symbol Name Standardized Value
CXADR coxsackie virus and adenovirus receptor -4.92999
TM9SF3 transmembrane 9 superfamily member 3 -4.32522
NUP85 nucleoporin 85kDa -3.85733
LAP3 leucine aminopeptidase 3 -3.64688
APOH apolipoprotein H (beta-2-glycoprotein I) -3.63575
KCTD2 potassium channel tetramerization domain containing 2 -3.59758
GFOD1 glucose-fructose oxidoreductase domain containing 1 -3.34946
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -3.3456
MT1X metallothionein 1X -3.32639
IL17RB interleukin 17 receptor B -3.30559
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.26714
APOA2 apolipoprotein A-II -3.22761
NGRN neugrin, neurite outgrowth associated -3.20738
ENOPH1 enolase-phosphatase 1 -3.17338
BIRC2 baculoviral IAP repeat containing 2 -3.09946
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.05681
SMNDC1 survival motor neuron domain containing 1 -2.98962
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -2.98597
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.93294
ACOX1 acyl-CoA oxidase 1, palmitoyl -2.91497
LYRM1 LYR motif containing 1 -2.89879
TF transferrin -2.87694
SLC38A12 solute carrier family 38 member 12 -2.85646
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.8047
RPN1 ribophorin I -2.70198
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.61823
MTFR1 mitochondrial fission regulator 1 -2.58337
C3 complement component 3 -2.42171
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.42131
WDR45B WD repeat domain 45B -2.41383
SPINK1 serine peptidase inhibitor, Kazal type 1 -2.38494
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -2.36085
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -2.33101
MRPS7 mitochondrial ribosomal protein S7 -2.30676
CIB1 calcium and integrin binding 1 (calmyrin) -2.27738
PRCP prolylcarboxypeptidase (angiotensinase C) -2.27124
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) -2.2657
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -2.24555
MACO1 macoilin 1 -2.24495
SAP30BP SAP30 binding protein -2.23744
C1R complement component 1, r subcomponent -2.23485
C1S complement component 1, s subcomponent -2.2219
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.19953
HMOX1 heme oxygenase 1 -2.1723
CCNH cyclin H -2.17116
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.16068
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) -2.16066
RNF4 ring finger protein 4 -2.15826
WIPI1 WD repeat domain, phosphoinositide interacting 1 -2.14483
TMED5 transmembrane emp24 protein transport domain containing 5 -2.12119
FBF1 Fas (TNFRSF6) binding factor 1 -2.11773
TBC1D2 TBC1 domain family, member 2 -2.10575
LOC102724560 cystathionine beta-synthase -2.10243
CPE carboxypeptidase E -2.09842
POM121C POM121 transmembrane nucleoporin C -2.06134
DDIT4 DNA-damage-inducible transcript 4 -2.05432
ZNF250 zinc finger protein 250 -2.04915
CTRB1 chymotrypsinogen B1 -2.04402
CFI complement factor I -2.02397