CRCGN015_HEPG2_48H:H24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description CH-223191 11.21 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

65 genes differentially expressed following the CRCGN015_HEPG2_48H:H24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 3.80978
BTK Bruton agammaglobulinemia tyrosine kinase 3.74209
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.28612
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.2742
FCHO1 FCH domain only 1 3.15581
PRKCH protein kinase C, eta 2.94361
TRIB1 tribbles pseudokinase 1 2.81928
ZFP36 ZFP36 ring finger protein 2.76083
MILR1 mast cell immunoglobulin-like receptor 1 2.74133
EPN2 epsin 2 2.62745
TRIB3 tribbles pseudokinase 3 2.5364
BAD BCL2-associated agonist of cell death 2.49899
ARHGAP12 Rho GTPase activating protein 12 2.43104
UBE2A ubiquitin-conjugating enzyme E2A 2.40112
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 2.20336
SQSTM1 sequestosome 1 2.19646
CRELD2 cysteine-rich with EGF-like domains 2 2.11912
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 2.11748
INPP1 inositol polyphosphate-1-phosphatase 2.08743
FAM193A family with sequence similarity 193, member A 2.0582
CNTN1 contactin 1 2.03943
DEPDC5 DEP domain containing 5 2.01726

decreased expression

Symbol Name Standardized Value
KDM3A lysine (K)-specific demethylase 3A -4.39446
PUF60 poly-U binding splicing factor 60KDa -4.04119
PECR peroxisomal trans-2-enoyl-CoA reductase -3.8508
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.75321
ZNF274 zinc finger protein 274 -3.38356
HPRT1 hypoxanthine phosphoribosyltransferase 1 -3.09793
PCCB propionyl CoA carboxylase, beta polypeptide -3.00283
NELFCD negative elongation factor complex member C/D -2.94586
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.85801
PDLIM1 PDZ and LIM domain 1 -2.74924
GNAS GNAS complex locus -2.71224
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.70424
RHOB ras homolog family member B -2.70395
PDZD2 PDZ domain containing 2 -2.55555
UBE2C ubiquitin-conjugating enzyme E2C -2.52991
PGAM4 phosphoglycerate mutase family member 4 -2.52848
FAIM Fas apoptotic inhibitory molecule -2.4829
NGRN neugrin, neurite outgrowth associated -2.44063
CXADR coxsackie virus and adenovirus receptor -2.37794
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 -2.34806
HIRIP3 HIRA interacting protein 3 -2.33516
STMN1 stathmin 1 -2.27914
CEP70 centrosomal protein 70kDa -2.23799
EVL Enah/Vasp-like -2.23512
ZBTB35 zinc finger and BTB domain containing 35 -2.22948
ATP5F1E ATP synthase F1 subunit epsilon -2.22894
SAP30BP SAP30 binding protein -2.22012
S100A7 S100 calcium binding protein A7 -2.20047
EXD2 exonuclease 3'-5' domain containing 2 -2.19804
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -2.17697
RPL38 ribosomal protein L38 -2.15364
MKS1 Meckel syndrome, type 1 -2.14483
LMAN2L lectin, mannose-binding 2-like -2.12628
DBR1 debranching RNA lariats 1 -2.12387
TPMT thiopurine S-methyltransferase -2.10861
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) -2.09017
SHFL shiftless antiviral inhibitor of ribosomal frameshifting -2.08042
RTF2 replication termination factor 2 -2.07783
GPC4 glypican 4 -2.07566
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial -2.06584
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase -2.06075
UBC ubiquitin C -2.03494
ADA adenosine deaminase -2.00891