CRCGN015_HEPG2_48H:I08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phenformin 33.49 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

235 genes differentially expressed following the CRCGN015_HEPG2_48H:I08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CD8A CD8a molecule 4.66882
AARS1 alanyl-tRNA synthetase 1 4.3796
SCRN1 secernin 1 3.70526
TMEM50A transmembrane protein 50A 3.49005
AKT1 v-akt murine thymoma viral oncogene homolog 1 3.40842
CARS1 cysteinyl-tRNA synthetase 1 3.20251
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 3.20159
YARS1 tyrosyl-tRNA synthetase 1 3.12401
SNCA synuclein, alpha (non A4 component of amyloid precursor) 3.0896
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.00771
FHL2 four and a half LIM domains 2 3.00093
TRIB1 tribbles pseudokinase 1 2.89084
FPGS folylpolyglutamate synthase 2.88509
TSPAN4 tetraspanin 4 2.85901
SMIM40 small integral membrane protein 40 2.81924
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.77126
SH2D2A SH2 domain containing 2A 2.74953
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.73872
ZFP36 ZFP36 ring finger protein 2.65644
IL32 interleukin 32 2.65016
IL2RB interleukin 2 receptor, beta 2.64267
RALB v-ral simian leukemia viral oncogene homolog B 2.64014
GARS1 glycyl-tRNA synthetase 1 2.63024
TRAPPC3 trafficking protein particle complex 3 2.62315
VAT1 vesicle amine transport 1 2.62149
RIC8A RIC8 guanine nucleotide exchange factor A 2.61317
MVP major vault protein 2.60206
NARS1 asparaginyl-tRNA synthetase 1 2.6015
NANOS3 nanos homolog 3 (Drosophila) 2.56531
GLRX glutaredoxin (thioltransferase) 2.54402
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.52811
KLRC4-KLRK1 KLRC4-KLRK1 readthrough 2.52707
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 2.50463
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 2.49066
TPST2 tyrosylprotein sulfotransferase 2 2.4758
REXO2 RNA exonuclease 2 2.45403
SNX6 sorting nexin 6 2.44684
CEP170B centrosomal protein 170B 2.44582
ITGB5 integrin, beta 5 2.43373
INPP1 inositol polyphosphate-1-phosphatase 2.41805
PYGB phosphorylase, glycogen; brain 2.38524
IGF2R insulin-like growth factor 2 receptor 2.36763
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.35073
VGLL4 vestigial-like family member 4 2.33447
TMEM80 transmembrane protein 80 2.33189
VASP vasodilator-stimulated phosphoprotein 2.31029
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 2.29761
ITFG1 integrin alpha FG-GAP repeat containing 1 2.28207
IFITM3 interferon induced transmembrane protein 3 2.27509
SQSTM1 sequestosome 1 2.27137
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 2.27053
EFHD1 EF-hand domain family, member D1 2.26599
TLCD3A TLC domain containing 3A 2.25358
DENND2B DENN domain containing 2B 2.25291
DNM1 dynamin 1 2.24964
RAB27A RAB27A, member RAS oncogene family 2.24206
TACC2 transforming, acidic coiled-coil containing protein 2 2.2394
HEBP1 heme binding protein 1 2.23681
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.23623
CAMK1 calcium/calmodulin-dependent protein kinase I 2.23575
TATDN2 TatD DNase domain containing 2 2.22906
BLVRA biliverdin reductase A 2.22115
DBN1 drebrin 1 2.21588
GIPC1 GIPC PDZ domain containing family, member 1 2.21408
GPX4 glutathione peroxidase 4 2.20939
TRIM37 tripartite motif containing 37 2.20163
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2.19548
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 2.18896
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 2.17348
TIMP2 TIMP metallopeptidase inhibitor 2 2.17199
GSDME gasdermin E 2.15232
GTF2IRD1 GTF2I repeat domain containing 1 2.1471
DUSP5 dual specificity phosphatase 5 2.13603
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2.12753
LAP3 leucine aminopeptidase 3 2.12729
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 2.12366
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 2.11406
MOSPD3 motile sperm domain containing 3 2.11357
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 2.10497
ACOT9 acyl-CoA thioesterase 9 2.093
WARS1 tryptophanyl-tRNA synthetase 1 2.09111
ACO2 aconitase 2, mitochondrial 2.09012
DEAF1 DEAF1 transcription factor 2.08216
CD151 CD151 molecule (Raph blood group) 2.07565
TALDO1 transaldolase 1 2.07257
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa 2.05047
H2BC21 H2B clustered histone 21 2.04646
GSAP gamma-secretase activating protein 2.04513
GSR glutathione reductase 2.04208
ALOX5AP arachidonate 5-lipoxygenase-activating protein 2.03806
CCDC169-SOHLH2 CCDC169-SOHLH2 readthrough 2.02543
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 2.02484
DUSP6 dual specificity phosphatase 6 2.02422
RAB5C RAB5C, member RAS oncogene family 2.02118
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 2.01833
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 2.01398
ACTA1 actin, alpha 1, skeletal muscle 2.01364
CST7 cystatin F (leukocystatin) 2.00766
MYH9 myosin, heavy chain 9, non-muscle 2.00069
CYFIP1 cytoplasmic FMR1 interacting protein 1 2.00059

decreased expression

Symbol Name Standardized Value
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -5.55056
CETN3 centrin, EF-hand protein, 3 -4.57515
PGRMC1 progesterone receptor membrane component 1 -3.86955
KIF20A kinesin family member 20A -3.75565
OIP5 Opa interacting protein 5 -3.70328
ISOC1 isochorismatase domain containing 1 -3.67964
PECR peroxisomal trans-2-enoyl-CoA reductase -3.54765
SESN1 sestrin 1 -3.39697
RPA3 replication protein A3, 14kDa -3.29126
LBR lamin B receptor -3.28684
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.14178
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.13363
MORC4 MORC family CW-type zinc finger 4 -3.08805
NME6 NME/NM23 nucleoside diphosphate kinase 6 -3.05652
KHDC4 KH domain containing 4, pre-mRNA splicing factor -2.8954
SPC25 SPC25, NDC80 kinetochore complex component -2.86872
SPAG5 sperm associated antigen 5 -2.8436
CENPE centromere protein E, 312kDa -2.80864
PLK1 polo-like kinase 1 -2.80523
FAM53C family with sequence similarity 53, member C -2.78528
TPGS1 tubulin polyglutamylase complex subunit 1 -2.76882
EPM2AIP1 EPM2A (laforin) interacting protein 1 -2.73573
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -2.72054
SPDL1 spindle apparatus coiled-coil protein 1 -2.71838
TSPYL5 TSPY-like 5 -2.69533
GCA grancalcin, EF-hand calcium binding protein -2.68767
HMOX1 heme oxygenase 1 -2.68195
TRAIP TRAF interacting protein -2.67648
MIS12 MIS12 kinetochore complex component -2.67181
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.65784
CDC25C cell division cycle 25C -2.65429
DDB2 damage-specific DNA binding protein 2, 48kDa -2.64807
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.6376
UBE4A ubiquitination factor E4A -2.6351
CDC23 cell division cycle 23 -2.61161
HADH hydroxyacyl-CoA dehydrogenase -2.61132
FHIT fragile histidine triad -2.60535
KIF11 kinesin family member 11 -2.60057
HJURP Holliday junction recognition protein -2.589
CSF3R colony stimulating factor 3 receptor (granulocyte) -2.56441
TK1 thymidine kinase 1, soluble -2.54485
PCNP PEST proteolytic signal containing nuclear protein -2.54456
WDR73 WD repeat domain 73 -2.5393
SMNDC1 survival motor neuron domain containing 1 -2.52851
TP53RK TP53 regulating kinase -2.51831
ZNF14 zinc finger protein 14 -2.51794
GIN1 gypsy retrotransposon integrase 1 -2.50616
MED7 mediator complex subunit 7 -2.50463
ERI2 ERI1 exoribonuclease family member 2 -2.4949
PARPBP PARP1 binding protein -2.49339
NLRP4 NLR family, pyrin domain containing 4 -2.47329
MNS1 meiosis-specific nuclear structural 1 -2.46307
PURA purine-rich element binding protein A -2.45444
PPIH peptidylprolyl isomerase H (cyclophilin H) -2.43783
BIRC5 baculoviral IAP repeat containing 5 -2.42764
GEMIN6 gem (nuclear organelle) associated protein 6 -2.42669
TMEM39A transmembrane protein 39A -2.41437
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.40248
CASP8AP2 caspase 8 associated protein 2 -2.38429
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 -2.37573
ZNF200 zinc finger protein 200 -2.36746
ANKRD49 ankyrin repeat domain 49 -2.36602
RIDA reactive intermediate imine deaminase A homolog -2.35276
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -2.35052
DERL2 derlin 2 -2.33542
STIL SCL/TAL1 interrupting locus -2.32974
ARCN1 archain 1 -2.32218
KIF14 kinesin family member 14 -2.31619
AURKB aurora kinase B -2.30844
MCM10 minichromosome maintenance complex component 10 -2.30832
GID8 GID complex subunit 8 -2.30344
SMC3 structural maintenance of chromosomes 3 -2.30324
COX7B cytochrome c oxidase subunit VIIb -2.29205
METTL18 methyltransferase like 18 -2.28749
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.28079
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.27599
MTFR1 mitochondrial fission regulator 1 -2.25446
ENY2 enhancer of yellow 2 homolog (Drosophila) -2.25253
REXO5 RNA exonuclease 5 -2.24925
ATAD2 ATPase family, AAA domain containing 2 -2.23571
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa -2.21743
SKA1 spindle and kinetochore associated complex subunit 1 -2.20406
UIMC1 ubiquitin interaction motif containing 1 -2.20029
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae) -2.19647
PRPS2 phosphoribosyl pyrophosphate synthetase 2 -2.17926
CENPI centromere protein I -2.17146
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.15927
IGFBP7 insulin-like growth factor binding protein 7 -2.15717
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.15471
THAP11 THAP domain containing 11 -2.1545
FAM13B family with sequence similarity 13, member B -2.15359
RCC1 regulator of chromosome condensation 1 -2.15179
E2F8 E2F transcription factor 8 -2.14808
FEN1 flap structure-specific endonuclease 1 -2.14752
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.14164
KIFBP kinesin family binding protein -2.13143
FANCI Fanconi anemia, complementation group I -2.11817
ASF1B anti-silencing function 1B histone chaperone -2.11503
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 -2.11385
APIP APAF1 interacting protein -2.112
NEK2 NIMA-related kinase 2 -2.10352
MED28 mediator complex subunit 28 -2.10304
SCYL3 SCY1-like 3 (S. cerevisiae) -2.10046
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.0983
FAM200C family with sequence similarity 200 member C -2.09605
AUNIP aurora kinase A and ninein interacting protein -2.09156
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -2.08982
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.08963
KRT85 keratin 85, type II -2.08167
KLK11 kallikrein-related peptidase 11 -2.07366
FGF18 fibroblast growth factor 18 -2.07241
CDT1 chromatin licensing and DNA replication factor 1 -2.07099
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.06818
KIF18A kinesin family member 18A -2.06547
CDKN3 cyclin-dependent kinase inhibitor 3 -2.06361
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.06279
DTD1 D-tyrosyl-tRNA deacylase 1 -2.06171
RBMX2 RNA binding motif protein, X-linked 2 -2.05738
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -2.04761
SOAT2 sterol O-acyltransferase 2 -2.04272
NFRKB nuclear factor related to kappaB binding protein -2.04224
NKIRAS2 NFKB inhibitor interacting Ras-like 2 -2.04019
CCNA2 cyclin A2 -2.03277
ECH1 enoyl CoA hydratase 1, peroxisomal -2.03234
COX7C cytochrome c oxidase subunit VIIc -2.02958
TMED3 transmembrane emp24 protein transport domain containing 3 -2.02774
POLK polymerase (DNA directed) kappa -2.02722
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -2.02324
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -2.02242
RSL1D1 ribosomal L1 domain containing 1 -2.02091
TTK TTK protein kinase -2.01462
ZNF267 zinc finger protein 267 -2.00924
LYRM1 LYR motif containing 1 -2.0053
CCNB2 cyclin B2 -2.00141
ARID4A AT rich interactive domain 4A (RBP1-like) -2.0009