CRCGN015_HEPG2_48H:I14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description toluene diisocyanate 33.93 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN015_HEPG2_48H:I14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TNIP1 TNFAIP3 interacting protein 1 4.21277
CBR3 carbonyl reductase 3 3.85249
MRPL12 mitochondrial ribosomal protein L12 2.611
SNX6 sorting nexin 6 2.51693
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.49676
PGLS 6-phosphogluconolactonase 2.37485
SLC35B1 solute carrier family 35, member B1 2.34463
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 2.25198
NLRP2B NLR family pyrin domain containing 2B 2.22964
UFSP2 UFM1-specific peptidase 2 2.22097
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 2.18975
TWF2 twinfilin actin binding protein 2 2.17011
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 2.12011
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I 2.11713
MCUR1 mitochondrial calcium uniporter regulator 1 2.11065
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae) 2.07724
NUP133 nucleoporin 133kDa 2.07566
GRWD1 glutamate-rich WD repeat containing 1 2.07486
AARS1 alanyl-tRNA synthetase 1 2.06903
ECI2 enoyl-CoA delta isomerase 2 2.06157
CSK c-src tyrosine kinase 2.03669
CASC3 cancer susceptibility candidate 3 2.0321
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 2.0092
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) 2.00725

decreased expression

Symbol Name Standardized Value
CXADR coxsackie virus and adenovirus receptor -6.13934
S100P S100 calcium binding protein P -4.36906
MT1X metallothionein 1X -3.80369
HEATR1 HEAT repeat containing 1 -3.66296
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -2.95276
TFRC transferrin receptor -2.8781
ZMIZ1 zinc finger, MIZ-type containing 1 -2.42443
IGFBP7 insulin-like growth factor binding protein 7 -2.34103
RPN1 ribophorin I -2.31447
CSF3R colony stimulating factor 3 receptor (granulocyte) -2.16166
CSRP2 cysteine and glycine-rich protein 2 -2.13621
APOA2 apolipoprotein A-II -2.13002
HCAR3 hydroxycarboxylic acid receptor 3 -2.11075
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -2.1074
CCNP cyclin P -2.00757