CRCGN015_HEPG2_48H:I19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description thiotepa 98.88 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

62 genes differentially expressed following the CRCGN015_HEPG2_48H:I19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 4.76379
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 4.74588
NR1H2 nuclear receptor subfamily 1, group H, member 2 4.0078
SCRN1 secernin 1 3.66709
SNX11 sorting nexin 11 3.42875
CRTAP cartilage associated protein 3.34344
KDM5A lysine (K)-specific demethylase 5A 3.00153
CBR3 carbonyl reductase 3 2.95638
TUBB6 tubulin, beta 6 class V 2.90089
DDB2 damage-specific DNA binding protein 2, 48kDa 2.77717
GTPBP8 GTP-binding protein 8 (putative) 2.54155
NUCB2 nucleobindin 2 2.50167
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.44312
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 2.41738
HYOU1 hypoxia up-regulated 1 2.3711
LOC127933115 uncharacterized LOC127933115 2.36609
COLGALT2 collagen beta(1-O)galactosyltransferase 2 2.26997
ZMAT3 zinc finger, matrin-type 3 2.24177
APLP2 amyloid beta (A4) precursor-like protein 2 2.23496
PNRC1 proline-rich nuclear receptor coactivator 1 2.21374
MICALL1 MICAL-like 1 2.16516
IGF2R insulin-like growth factor 2 receptor 2.13793
CTSB cathepsin B 2.13773
ZNF510 zinc finger protein 510 2.11298
CEMIP2 cell migration inducing hyaluronidase 2 2.10834
PARP4 poly (ADP-ribose) polymerase family, member 4 2.09574
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.00748
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.00402

decreased expression

Symbol Name Standardized Value
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -4.15495
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.9363
TES testin LIM domain protein -2.84847
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.66734
BABAM1 BRISC and BRCA1 A complex member 1 -2.59188
MTERF3 mitochondrial transcription termination factor 3 -2.41445
WDR12 WD repeat domain 12 -2.37187
TGDS TDP-glucose 4,6-dehydratase -2.3281
MRPL37 mitochondrial ribosomal protein L37 -2.29271
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.24795
RIDA reactive intermediate imine deaminase A homolog -2.23733
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -2.21518
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.21189
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) -2.20861
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.18255
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.18132
IL24 interleukin 24 -2.1551
THOC6 THO complex 6 -2.15046
SLC4A2 solute carrier family 4 (anion exchanger), member 2 -2.14045
PCID2 PCI domain containing 2 -2.09202
DCTN6 dynactin 6 -2.07716
WDR46 WD repeat domain 46 -2.07412
ATP5PB ATP synthase peripheral stalk-membrane subunit b -2.06024
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -2.05885
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.05249
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -2.05226
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.05166
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -2.04867
EXOSC5 exosome component 5 -2.03606
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 -2.02248
E2F5 E2F transcription factor 5, p130-binding -2.01157
FASTKD5 FAST kinase domains 5 -2.00661
PUF60 poly-U binding splicing factor 60KDa -2.00507
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.00063