CRCGN015_HEPG2_48H:I20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description thiotepa 32.96 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

13 genes differentially expressed following the CRCGN015_HEPG2_48H:I20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 3.92099
CBR3 carbonyl reductase 3 3.22195
CCNF cyclin F 2.35229
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.21724
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 2.21697
DDB2 damage-specific DNA binding protein 2, 48kDa 2.15234
ADAT1 adenosine deaminase, tRNA-specific 1 2.06247

decreased expression

Symbol Name Standardized Value
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.84915
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.26092
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.2504
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.21751
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -2.52322
MT1X metallothionein 1X -2.24472