CRCGN015_HEPG2_48H:I21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description thiotepa 10.99 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

24 genes differentially expressed following the CRCGN015_HEPG2_48H:I21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ANO10 anoctamin 10 5.31496
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 5.23786
FRS2 fibroblast growth factor receptor substrate 2 4.16007
EVL Enah/Vasp-like 4.1033
BACE2 beta-site APP-cleaving enzyme 2 3.69372
FZD7 frizzled class receptor 7 2.71335
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 2.67857
GRB10 growth factor receptor-bound protein 10 2.51833
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.19483
UBE4A ubiquitination factor E4A 2.11694
MYLK myosin light chain kinase 2.11449
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.0061

decreased expression

Symbol Name Standardized Value
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -5.28634
CD58 CD58 molecule -3.90128
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.57166
PROM1 prominin 1 -3.09354
CHIC2 cysteine-rich hydrophobic domain 2 -2.57733
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 -2.54457
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -2.41424
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.40108
SOAT2 sterol O-acyltransferase 2 -2.30347
CCNH cyclin H -2.22735
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.20732
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.20125