CRCGN015_HEPG2_48H:I22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tryptophan 100.97 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

546 genes differentially expressed following the CRCGN015_HEPG2_48H:I22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.55509
CEMIP2 cell migration inducing hyaluronidase 2 4.19837
WDR7 WD repeat domain 7 4.08564
MVP major vault protein 4.03603
EXOC1 exocyst complex component 1 3.96486
VAT1 vesicle amine transport 1 3.93419
CDPF1 cysteine-rich, DPF motif domain containing 1 3.88758
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 3.83712
RAP1GAP RAP1 GTPase activating protein 3.77586
TSPAN3 tetraspanin 3 3.69661
SNX7 sorting nexin 7 3.58304
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.58289
CYTH1 cytohesin 1 3.49004
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 3.41719
H2BC21 H2B clustered histone 21 3.40497
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.32101
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 3.31564
RABAC1 Rab acceptor 1 (prenylated) 3.25488
OSGIN1 oxidative stress induced growth inhibitor 1 3.24561
HABP4 hyaluronan binding protein 4 3.2273
SQSTM1 sequestosome 1 3.20455
RALB v-ral simian leukemia viral oncogene homolog B 3.19097
TMEM50A transmembrane protein 50A 3.18604
DHRS7 dehydrogenase/reductase (SDR family) member 7 3.17558
WASHC3 WASH complex subunit 3 3.12741
TSKU tsukushi, small leucine rich proteoglycan 3.08471
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 3.0122
SQOR sulfide quinone oxidoreductase 3.00264
LPGAT1 lysophosphatidylglycerol acyltransferase 1 3.00121
NPTN neuroplastin 2.9757
YPEL5 yippee-like 5 (Drosophila) 2.96363
TP53I3 tumor protein p53 inducible protein 3 2.96021
ITFG1 integrin alpha FG-GAP repeat containing 1 2.92903
HMOX1 heme oxygenase 1 2.87001
BAMBI BMP and activin membrane-bound inhibitor 2.84708
RHOC ras homolog family member C 2.83993
TCN2 transcobalamin II 2.8361
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 2.77284
IFFO1 intermediate filament family orphan 1 2.7692
RNF111 ring finger protein 111 2.76721
ARID5A AT rich interactive domain 5A (MRF1-like) 2.72628
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 2.71778
TRIP4 thyroid hormone receptor interactor 4 2.68527
SPG11 spastic paraplegia 11 (autosomal recessive) 2.66289
OSTF1 osteoclast stimulating factor 1 2.65819
CTSO cathepsin O 2.61909
FPGS folylpolyglutamate synthase 2.619
FRMD4B FERM domain containing 4B 2.60432
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) 2.6005
H2AC19 H2A clustered histone 19 2.58823
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.5752
MYH9 myosin, heavy chain 9, non-muscle 2.56885
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 2.55685
VLDLR very low density lipoprotein receptor 2.54507
SDCBP syndecan binding protein (syntenin) 2.54307
SLC38A10 solute carrier family 38, member 10 2.53133
NAGLU N-acetylglucosaminidase, alpha 2.528
ETFB electron-transfer-flavoprotein, beta polypeptide 2.51914
KCTD17 potassium channel tetramerization domain containing 17 2.51806
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 2.51189
DUSP6 dual specificity phosphatase 6 2.51121
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.50995
FAM174B family with sequence similarity 174, member B 2.50829
ZFAND5 zinc finger, AN1-type domain 5 2.50704
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.50023
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.49887
MIDEAS mitotic deacetylase associated SANT domain protein 2.49694
LGALS9C lectin, galactoside-binding, soluble, 9C 2.48418
TMEM14A transmembrane protein 14A 2.48174
ATOSB atos homolog B 2.4699
IRF2 interferon regulatory factor 2 2.46137
TXNRD1 thioredoxin reductase 1 2.46023
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.4468
STBD1 starch binding domain 1 2.43765
FKBP1B FK506 binding protein 1B, 12.6 kDa 2.43204
GCLC glutamate-cysteine ligase, catalytic subunit 2.42457
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.42013
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 2.41702
TDRD7 tudor domain containing 7 2.4127
BECN1 beclin 1, autophagy related 2.40482
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.4046
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 2.37633
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.35932
TRPV2 transient receptor potential cation channel, subfamily V, member 2 2.35585
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 2.35434
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.35336
SHFL shiftless antiviral inhibitor of ribosomal frameshifting 2.34775
TMEM165 transmembrane protein 165 2.34453
REXO2 RNA exonuclease 2 2.34336
CST4 cystatin S 2.33156
BMP4 bone morphogenetic protein 4 2.32384
TRIM11 tripartite motif containing 11 2.32037
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.31363
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 2.31187
IFI35 interferon-induced protein 35 2.30826
INPP1 inositol polyphosphate-1-phosphatase 2.30619
CST1 cystatin SN 2.30529
TLR4 toll-like receptor 4 2.3051
KIF3C kinesin family member 3C 2.29811
KIFAP3 kinesin-associated protein 3 2.29316
RNF103-CHMP3 RNF103-CHMP3 readthrough 2.28863
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 2.28328
CCDC86 coiled-coil domain containing 86 2.28026
CTSE cathepsin E 2.27217
HOXB3 homeobox B3 2.26828
RNF103 ring finger protein 103 2.26322
FHL2 four and a half LIM domains 2 2.2623
KLF2 Kruppel-like factor 2 2.24053
TNK1 tyrosine kinase, non-receptor, 1 2.23655
APOL1 apolipoprotein L, 1 2.23579
SLC67A1 solute carrier family 67 member 1 2.23399
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 2.23327
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 2.23257
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 2.23252
ZFP36 ZFP36 ring finger protein 2.22787
WASHC4 WASH complex subunit 4 2.2262
SPATA20 spermatogenesis associated 20 2.22037
NXF3 nuclear RNA export factor 3 2.2157
MAPK13 mitogen-activated protein kinase 13 2.20311
CST2 cystatin SA 2.20001
CCL15 chemokine (C-C motif) ligand 15 2.19577
STX8 syntaxin 8 2.19206
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.18994
PPARG peroxisome proliferator-activated receptor gamma 2.18659
PARP3 poly (ADP-ribose) polymerase family, member 3 2.18334
ACVR1 activin A receptor, type I 2.18135
TMEM106B transmembrane protein 106B 2.17882
TMEM53 transmembrane protein 53 2.17606
RAB11FIP5 RAB11 family interacting protein 5 (class I) 2.17451
ABHD4 abhydrolase domain containing 4 2.17189
TMEM35A transmembrane protein 35A 2.16745
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae) 2.1568
GTF2B general transcription factor IIB 2.15535
CEP112 centrosomal protein 112kDa 2.15475
C15ORF38-AP3S2 C15orf38-AP3S2 readthrough 2.15446
AAMDC adipogenesis associated, Mth938 domain containing 2.15108
CLBA1 clathrin binding box of aftiphilin containing 1 2.14267
OPTN optineurin 2.14114
APOL2 apolipoprotein L, 2 2.13996
FOXA2 forkhead box A2 2.136
MMRN1 multimerin 1 2.12899
ITPKC inositol-trisphosphate 3-kinase C 2.12437
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 2.1243
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 2.12014
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 2.1197
SSTR3 somatostatin receptor 3 2.11943
STX12 syntaxin 12 2.11825
GBE1 glucan (1,4-alpha-), branching enzyme 1 2.11589
RAB11A RAB11A, member RAS oncogene family 2.11178
TM4SF20 transmembrane 4 L six family member 20 2.10928
CTSB cathepsin B 2.10854
MYO5A myosin VA (heavy chain 12, myoxin) 2.10005
TRIOBP TRIO and F-actin binding protein 2.09771
ARL8B ADP-ribosylation factor-like 8B 2.09283
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 2.09252
CARD10 caspase recruitment domain family, member 10 2.08732
MLPH melanophilin 2.08721
METTL25B methyltransferase like 25B 2.0853
WFDC2 WAP four-disulfide core domain 2 2.08435
ATF3 activating transcription factor 3 2.08252
GDI1 GDP dissociation inhibitor 1 2.0815
CSRNP2 cysteine-serine-rich nuclear protein 2 2.07734
RSU1 Ras suppressor protein 1 2.07529
LOC127933115 uncharacterized LOC127933115 2.07256
DKK4 dickkopf WNT signaling pathway inhibitor 4 2.07192
FKBP6 FK506 binding protein 6, 36kDa 2.06994
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 2.06976
PARP4 poly (ADP-ribose) polymerase family, member 4 2.06823
ACOT9 acyl-CoA thioesterase 9 2.06682
CYFIP1 cytoplasmic FMR1 interacting protein 1 2.06262
TRADD TNFRSF1A-associated via death domain 2.06179
ZBTB22 zinc finger and BTB domain containing 22 2.06156
RANGRF RAN guanine nucleotide release factor 2.0597
VPS9D1 VPS9 domain containing 1 2.05938
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 2.05225
RRAGC Ras-related GTP binding C 2.04918
TBX3 T-box 3 2.04567
GSDME gasdermin E 2.03999
N4BP2L1 NEDD4 binding protein 2-like 1 2.03918
SOX4 SRY (sex determining region Y)-box 4 2.03835
NMI N-myc (and STAT) interactor 2.03667
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 2.03504
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 2.03423
FGF9 fibroblast growth factor 9 2.03355
TMEM35B transmembrane protein 35B 2.02551
LMNA lamin A/C 2.02222
SERINC1 serine incorporator 1 2.01982
TNPO1 transportin 1 2.01667
RUSF1 RUS family member 1 2.01495
RNF128 ring finger protein 128, E3 ubiquitin protein ligase 2.01229
RTCA RNA 3'-terminal phosphate cyclase 2.00849
UNC93B1 unc-93 homolog B1 (C. elegans) 2.00094

decreased expression

Symbol Name Standardized Value
APOH apolipoprotein H (beta-2-glycoprotein I) -5.22623
PLK1 polo-like kinase 1 -5.11981
PECR peroxisomal trans-2-enoyl-CoA reductase -4.89867
OIP5 Opa interacting protein 5 -4.64283
UBE2C ubiquitin-conjugating enzyme E2C -4.48294
APOA2 apolipoprotein A-II -4.38198
KIF20A kinesin family member 20A -4.28287
AUNIP aurora kinase A and ninein interacting protein -4.23712
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -4.1019
ATAD2 ATPase family, AAA domain containing 2 -4.00638
NUP85 nucleoporin 85kDa -3.98319
KIF4A kinesin family member 4A -3.96124
CDT1 chromatin licensing and DNA replication factor 1 -3.95749
NCAPD2 non-SMC condensin I complex, subunit D2 -3.90915
BIRC5 baculoviral IAP repeat containing 5 -3.90382
SPC25 SPC25, NDC80 kinetochore complex component -3.88283
EXO1 exonuclease 1 -3.87329
CDC45 cell division cycle 45 -3.76886
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -3.71916
NUP93 nucleoporin 93kDa -3.69178
TRIP13 thyroid hormone receptor interactor 13 -3.67419
DEPDC1 DEP domain containing 1 -3.65416
CDCA8 cell division cycle associated 8 -3.64366
HMGN2 high mobility group nucleosomal binding domain 2 -3.58608
CCNA2 cyclin A2 -3.54177
CDC25C cell division cycle 25C -3.52637
MCM10 minichromosome maintenance complex component 10 -3.49086
CDCA3 cell division cycle associated 3 -3.48966
FEN1 flap structure-specific endonuclease 1 -3.45755
TPX2 TPX2, microtubule-associated -3.44277
FOXM1 forkhead box M1 -3.42266
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -3.40741
GGCT gamma-glutamylcyclotransferase -3.39996
CCNB2 cyclin B2 -3.39544
RACGAP1 Rac GTPase activating protein 1 -3.38401
VDAC1 voltage-dependent anion channel 1 -3.37697
TDP1 tyrosyl-DNA phosphodiesterase 1 -3.37275
HAT1 histone acetyltransferase 1 -3.36917
MIS18A MIS18 kinetochore protein A -3.34442
SPAG5 sperm associated antigen 5 -3.33955
ASF1B anti-silencing function 1B histone chaperone -3.31806
CCNF cyclin F -3.31756
RFC4 replication factor C (activator 1) 4, 37kDa -3.29537
TBP TATA box binding protein -3.23117
BORA bora, aurora kinase A activator -3.22837
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.21728
DSCC1 DNA replication and sister chromatid cohesion 1 -3.21378
MKI67 marker of proliferation Ki-67 -3.2029
CENPA centromere protein A -3.20119
HJURP Holliday junction recognition protein -3.19986
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites -3.18657
MRPS2 mitochondrial ribosomal protein S2 -3.18564
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.17897
CDC20 cell division cycle 20 -3.17148
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.16915
UBAC1 UBA domain containing 1 -3.15455
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa -3.14561
RFC3 replication factor C (activator 1) 3, 38kDa -3.14201
S100P S100 calcium binding protein P -3.13145
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.06912
NOLC1 nucleolar and coiled-body phosphoprotein 1 -3.06596
NDC1 NDC1 transmembrane nucleoporin -3.05603
GID8 GID complex subunit 8 -3.0555
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -3.04979
FANCC Fanconi anemia, complementation group C -3.04294
HMGA2 high mobility group AT-hook 2 -3.04277
NEK2 NIMA-related kinase 2 -3.04047
FBXO5 F-box protein 5 -3.0372
STMN1 stathmin 1 -3.0256
KIF18A kinesin family member 18A -3.02396
CDC6 cell division cycle 6 -3.00435
CDK1 cyclin-dependent kinase 1 -2.99912
AURKB aurora kinase B -2.99311
KIF14 kinesin family member 14 -2.99198
MCM3 minichromosome maintenance complex component 3 -2.97675
NCAPG2 non-SMC condensin II complex, subunit G2 -2.97568
MCM7 minichromosome maintenance complex component 7 -2.97392
CDK4 cyclin-dependent kinase 4 -2.96462
MRPL16 mitochondrial ribosomal protein L16 -2.94704
PTTG1 pituitary tumor-transforming 1 -2.93856
RAD54L RAD54-like (S. cerevisiae) -2.91957
TK1 thymidine kinase 1, soluble -2.90993
KIF22 kinesin family member 22 -2.90679
FANCG Fanconi anemia, complementation group G -2.88846
FBL fibrillarin -2.87199
PPIH peptidylprolyl isomerase H (cyclophilin H) -2.87106
DBF4 DBF4 zinc finger -2.87088
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 -2.87084
ENOPH1 enolase-phosphatase 1 -2.85738
NUSAP1 nucleolar and spindle associated protein 1 -2.85316
POLR1G RNA polymerase I subunit G -2.84731
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.83641
PYDC1 PYD (pyrin domain) containing 1 -2.83511
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B -2.81113
H2AZ2 H2A.Z variant histone 2 -2.80601
SMC3 structural maintenance of chromosomes 3 -2.79661
TTK TTK protein kinase -2.79465
PIMREG PICALM interacting mitotic regulator -2.79182
TCOF1 Treacher Collins-Franceschetti syndrome 1 -2.79053
TRMT5 tRNA methyltransferase 5 -2.78995
KIF18B kinesin family member 18B -2.78942
RFC2 replication factor C (activator 1) 2, 40kDa -2.78621
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 -2.78573
BRCA1 breast cancer 1, early onset -2.77993
E2F1 E2F transcription factor 1 -2.76834
UXT ubiquitously-expressed, prefoldin-like chaperone -2.76199
PTGES3 prostaglandin E synthase 3 (cytosolic) -2.76057
TROAP trophinin associated protein -2.75867
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.75081
NUP155 nucleoporin 155kDa -2.7473
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.742
KIF11 kinesin family member 11 -2.74192
NDC80 NDC80 kinetochore complex component -2.74036
SPDL1 spindle apparatus coiled-coil protein 1 -2.73107
CSE1L CSE1 chromosome segregation 1-like (yeast) -2.73097
CCNB1 cyclin B1 -2.72155
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.72076
RFWD3 ring finger and WD repeat domain 3 -2.71143
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.70262
ERCC6L excision repair cross-complementation group 6-like -2.69914
PSRC1 proline/serine-rich coiled-coil 1 -2.69873
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma -2.681
PARP1 poly (ADP-ribose) polymerase 1 -2.67937
NCAPH non-SMC condensin I complex, subunit H -2.67141
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -2.66507
CDC23 cell division cycle 23 -2.65992
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -2.65557
PRC1 protein regulator of cytokinesis 1 -2.64236
TMEM243 transmembrane protein 243, mitochondrial -2.64013
ZBTB39 zinc finger and BTB domain containing 39 -2.63624
DHFR dihydrofolate reductase -2.63589
NELFCD negative elongation factor complex member C/D -2.63201
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -2.62981
KIF15 kinesin family member 15 -2.62313
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.62155
MRPL11 mitochondrial ribosomal protein L11 -2.61898
SNRPF small nuclear ribonucleoprotein polypeptide F -2.61871
MIMS2 mitochondrial inner membrane scaffold 2 -2.61688
NHLRC2 NHL repeat containing 2 -2.60893
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.59955
NUTF2 nuclear transport factor 2 -2.59338
SHCBP1 SHC SH2-domain binding protein 1 -2.59177
DENND1A DENN/MADD domain containing 1A -2.587
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.58312
VRK1 vaccinia related kinase 1 -2.58095
PGM1 phosphoglucomutase 1 -2.58063
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 -2.57429
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -2.57118
SSRP1 structure specific recognition protein 1 -2.56994
NOL9 nucleolar protein 9 -2.55975
POLE polymerase (DNA directed), epsilon, catalytic subunit -2.5487
EIF3J eukaryotic translation initiation factor 3, subunit J -2.53849
XPO7 exportin 7 -2.53253
LARP1 La ribonucleoprotein domain family, member 1 -2.52685
PHF10 PHD finger protein 10 -2.5241
PROSER1 proline and serine rich 1 -2.51502
KIFC1 kinesin family member C1 -2.51419
CNOT9 CCR4-NOT transcription complex subunit 9 -2.51395
EMP2 epithelial membrane protein 2 -2.50764
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 -2.50097
EIF3B eukaryotic translation initiation factor 3, subunit B -2.49998
MTERF3 mitochondrial transcription termination factor 3 -2.49879
TMEM97 transmembrane protein 97 -2.49622
MSH2 mutS homolog 2 -2.49523
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.4946
EXOSC8 exosome component 8 -2.489
TFDP1 transcription factor Dp-1 -2.48773
FAF1 Fas (TNFRSF6) associated factor 1 -2.48362
LBR lamin B receptor -2.47577
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.47323
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -2.46894
ARHGAP11A Rho GTPase activating protein 11A -2.44621
SKI SKI proto-oncogene -2.44101
ATP5IF1 ATP synthase inhibitory factor subunit 1 -2.43134
USP1 ubiquitin specific peptidase 1 -2.43105
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -2.43054
PA2G4 proliferation-associated 2G4, 38kDa -2.42948
MYO19 myosin XIX -2.42827
CKS1B CDC28 protein kinase regulatory subunit 1B -2.42792
REXO5 RNA exonuclease 5 -2.42454
FANCI Fanconi anemia, complementation group I -2.41882
MED28 mediator complex subunit 28 -2.41589
LMNB1 lamin B1 -2.41242
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.40657
NSD2 nuclear receptor binding SET domain protein 2 -2.40259
TMPO thymopoietin -2.40179
PTMA prothymosin, alpha -2.40084
PAGR1 PAXIP1 associated glutamate-rich protein 1 -2.40024
ELOVL6 ELOVL fatty acid elongase 6 -2.39711
HAUS7 HAUS augmin-like complex, subunit 7 -2.39567
PM20D1 peptidase M20 domain containing 1 -2.39321
ALDOC aldolase C, fructose-bisphosphate -2.3931
NCAPD3 non-SMC condensin II complex, subunit D3 -2.39015
CHURC1-FNTB CHURC1-FNTB readthrough -2.38626
PBK PDZ binding kinase -2.38425
VAV3 vav 3 guanine nucleotide exchange factor -2.38005
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -2.37621
POM121C POM121 transmembrane nucleoporin C -2.37136
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant -2.37069
TXLNG taxilin gamma -2.35893
COQ3 coenzyme Q3 methyltransferase -2.35793
ADNP activity-dependent neuroprotector homeobox -2.35739
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -2.35494
PRRC2B proline-rich coiled-coil 2B -2.34797
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 -2.34331
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.33859
PLK4 polo-like kinase 4 -2.33767
GTSE1 G-2 and S-phase expressed 1 -2.33472
THAP11 THAP domain containing 11 -2.33226
POLR1E polymerase (RNA) I polypeptide E, 53kDa -2.33207
DKC1 dyskeratosis congenita 1, dyskerin -2.33137
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.32931
TEDC2 tubulin epsilon and delta complex 2 -2.32736
RAD51AP1 RAD51 associated protein 1 -2.32553
SETD6 SET domain containing 6 -2.32291
SDF2L1 stromal cell-derived factor 2-like 1 -2.31989
HMGB2 high mobility group box 2 -2.31844
ARHGAP19 Rho GTPase activating protein 19 -2.31785
TMEM267 transmembrane protein 267 -2.31741
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.31447
ABI2 abl-interactor 2 -2.31339
RECQL4 RecQ protein-like 4 -2.31187
CENPS-CORT CENPS-CORT readthrough -2.31133
IFITM1 interferon induced transmembrane protein 1 -2.31113
DNA2 DNA replication helicase/nuclease 2 -2.30138
AGO2 argonaute RISC catalytic component 2 -2.30133
TMEM258 transmembrane protein 258 -2.30079
PLAGL2 pleiomorphic adenoma gene-like 2 -2.29975
HELLS helicase, lymphoid-specific -2.29385
HDAC3 histone deacetylase 3 -2.29191
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) -2.28834
SUZ12 SUZ12 polycomb repressive complex 2 subunit -2.28606
WDR76 WD repeat domain 76 -2.27668
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa -2.27535
CTCF CCCTC-binding factor (zinc finger protein) -2.27523
SESN1 sestrin 1 -2.27413
NAE1 NEDD8 activating enzyme E1 subunit 1 -2.27173
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.2657
CHAF1A chromatin assembly factor 1, subunit A (p150) -2.26551
MGMT O-6-methylguanine-DNA methyltransferase -2.25977
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -2.2588
AURKA aurora kinase A -2.25202
CDK2 cyclin-dependent kinase 2 -2.251
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) -2.2467
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) -2.24578
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 -2.24575
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.24358
NUP160 nucleoporin 160kDa -2.24051
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.24016
POMZP3 POM121 and ZP3 fusion -2.23966
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 -2.2396
RPA3 replication protein A3, 14kDa -2.23335
CCDC59 coiled-coil domain containing 59 -2.22928
SEH1L SEH1-like (S. cerevisiae) -2.22616
GPHN gephyrin -2.22117
CD320 CD320 molecule -2.22003
ZWINT ZW10 interacting kinetochore protein -2.21931
SLC2A4RG SLC2A4 regulator -2.21768
KNTC1 kinetochore associated 1 -2.21233
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.20963
RRM1 ribonucleotide reductase M1 -2.20229
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) -2.19616
BLM Bloom syndrome, RecQ helicase-like -2.19356
NASP nuclear autoantigenic sperm protein (histone-binding) -2.19088
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) -2.18972
RCC1 regulator of chromosome condensation 1 -2.18804
CRLF3 cytokine receptor-like factor 3 -2.18506
HOXC10 homeobox C10 -2.18289
SPOUT1 SPOUT domain containing methyltransferase 1 -2.18244
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A -2.18169
SKA1 spindle and kinetochore associated complex subunit 1 -2.17958
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -2.1746
C5 complement component 5 -2.17204
POLR2D polymerase (RNA) II (DNA directed) polypeptide D -2.17035
CCDC85C coiled-coil domain containing 85C -2.16602
EDC4 enhancer of mRNA decapping 4 -2.16547
MCM5 minichromosome maintenance complex component 5 -2.16178
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -2.15359
SIPA1L1 signal-induced proliferation-associated 1 like 1 -2.15346
HMGB1 high mobility group box 1 -2.15171
NHP2 NHP2 ribonucleoprotein -2.13807
COIL coilin -2.13318
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator -2.13119
KIF23 kinesin family member 23 -2.13075
TLE3 transducin-like enhancer of split 3 -2.13036
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -2.12979
DHCR7 7-dehydrocholesterol reductase -2.12492
TEAD4 TEA domain family member 4 -2.12452
CENPI centromere protein I -2.12212
PSAT1 phosphoserine aminotransferase 1 -2.11607
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 -2.10837
PRMT5 protein arginine methyltransferase 5 -2.10099
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) -2.09998
ADGRE3 adhesion G protein-coupled receptor E3 -2.09956
CDCA4 cell division cycle associated 4 -2.09873
TOP2A topoisomerase (DNA) II alpha 170kDa -2.09871
U2SURP U2 snRNP-associated SURP domain containing -2.09845
PDCD5 programmed cell death 5 -2.09656
SPATA5L1 spermatogenesis associated 5-like 1 -2.09452
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -2.09413
QSER1 glutamine and serine rich 1 -2.09216
COASY CoA synthase -2.092
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.08446
BRD7 bromodomain containing 7 -2.08315
HMBS hydroxymethylbilane synthase -2.08202
MCM4 minichromosome maintenance complex component 4 -2.08095
SHMT1 serine hydroxymethyltransferase 1 (soluble) -2.08004
ENTR1 endosome associated trafficking regulator 1 -2.0772
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.07683
DCLRE1A DNA cross-link repair 1A -2.07593
PMPCA peptidase (mitochondrial processing) alpha -2.07578
DELE1 DAP3 binding cell death enhancer 1 -2.07491
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.07075
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.06843
SRP9 signal recognition particle 9kDa -2.06288
POLK polymerase (DNA directed) kappa -2.06196
CEP57 centrosomal protein 57kDa -2.0597
DONSON downstream neighbor of SON -2.05949
SFMBT1 Scm-like with four mbt domains 1 -2.0587
S100B S100 calcium binding protein B -2.0549
TBL1X transducin (beta)-like 1X-linked -2.05053
BRIX1 BRX1, biogenesis of ribosomes -2.05033
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.04888
S100A4 S100 calcium binding protein A4 -2.0465
CDC25A cell division cycle 25A -2.04319
HBQ1 hemoglobin, theta 1 -2.04155
MTFR1 mitochondrial fission regulator 1 -2.04115
AATF apoptosis antagonizing transcription factor -2.04027
FANCA Fanconi anemia, complementation group A -2.03939
BAG4 BCL2-associated athanogene 4 -2.03754
RAD21 RAD21 homolog (S. pombe) -2.03705
BRAF B-Raf proto-oncogene, serine/threonine kinase -2.03584
ISOC1 isochorismatase domain containing 1 -2.03556
ARPC5L actin related protein 2/3 complex, subunit 5-like -2.03498
JPT2 Jupiter microtubule associated homolog 2 -2.03094
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.02691
ARF1 ADP-ribosylation factor 1 -2.02494
FOXRED2 FAD-dependent oxidoreductase domain containing 2 -2.02238
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -2.01982
GMEB2 glucocorticoid modulatory element binding protein 2 -2.01863
PHTF2 putative homeodomain transcription factor 2 -2.01719
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -2.01696
NEMP1 nuclear envelope integral membrane protein 1 -2.01586
HOXB9 homeobox B9 -2.01495
TCERG1 transcription elongation regulator 1 -2.01468
AHCTF1 AT hook containing transcription factor 1 -2.01192
CKAP2 cytoskeleton associated protein 2 -2.01174
CASP8AP2 caspase 8 associated protein 2 -2.01085
PTDSS1 phosphatidylserine synthase 1 -2.00818
LOC124905743 low affinity immunoglobulin gamma Fc region receptor III-B -2.00802
UBXN8 UBX domain protein 8 -2.00792
USP39 ubiquitin specific peptidase 39 -2.00572
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) -2.00203
TBC1D10C TBC1 domain family, member 10C -2.00151