CRCGN015_HEPG2_48H:I24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tryptophan 11.22 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN015_HEPG2_48H:I24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCR4 chemokine (C-X-C motif) receptor 4 6.21942
SKIC2 SKI2 subunit of superkiller complex 4.36315
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.48911
ADGRE5 adhesion G protein-coupled receptor E5 3.47593
PRKCQ protein kinase C, theta 2.96435
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.92467
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.76863
CRELD2 cysteine-rich with EGF-like domains 2 2.58491
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 2.42239
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.28987
SIRT3 sirtuin 3 2.23036
AGPS alkylglycerone phosphate synthase 2.20412
FGFR2 fibroblast growth factor receptor 2 2.16483
LRRC8D leucine rich repeat containing 8 family, member D 2.14414

decreased expression

Symbol Name Standardized Value
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -4.47205
DERA deoxyribose-phosphate aldolase (putative) -4.11292
S100P S100 calcium binding protein P -3.74099
RPIA ribose 5-phosphate isomerase A -3.42555
LYPLA1 lysophospholipase I -3.37105
TRIB3 tribbles pseudokinase 3 -2.92236
YME1L1 YME1-like 1 ATPase -2.89349
DCK deoxycytidine kinase -2.8346
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -2.7096
UGDH UDP-glucose 6-dehydrogenase -2.6961
GGCT gamma-glutamylcyclotransferase -2.41503
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.35378
CXADR coxsackie virus and adenovirus receptor -2.23644
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 -2.20988
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.19513
CD58 CD58 molecule -2.17914
TXNRD1 thioredoxin reductase 1 -2.10416
MRPL15 mitochondrial ribosomal protein L15 -2.04226
TIMP4 TIMP metallopeptidase inhibitor 4 -2.01172