CRCGN015_HEPG2_48H:J07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ethinyl estradiol 99.3 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

96 genes differentially expressed following the CRCGN015_HEPG2_48H:J07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
EDN1 endothelin 1 3.74907
CRELD2 cysteine-rich with EGF-like domains 2 3.15699
CDPF1 cysteine-rich, DPF motif domain containing 1 3.13992
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 3.04158
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.74883
NUCB2 nucleobindin 2 2.74386
ESM1 endothelial cell-specific molecule 1 2.72104
TUBB6 tubulin, beta 6 class V 2.7142
MAPKBP1 mitogen-activated protein kinase binding protein 1 2.60341
GBP1 guanylate binding protein 1, interferon-inducible 2.58419
STK10 serine/threonine kinase 10 2.3902
H2BC5 H2B clustered histone 5 2.3633
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 2.34547
JAK1 Janus kinase 1 2.32783
DERL2 derlin 2 2.32662
ANGPT2 angiopoietin 2 2.30025
MSN moesin 2.28653
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.2642
H2BC12 H2B clustered histone 12 2.22723
BLCAP bladder cancer associated protein 2.19983
TRIM5 tripartite motif containing 5 2.19422
CEMIP2 cell migration inducing hyaluronidase 2 2.1323
GRB10 growth factor receptor-bound protein 10 2.08575
TXNDC15 thioredoxin domain containing 15 2.07464
BIRC3 baculoviral IAP repeat containing 3 2.06332
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 2.05227
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.04932
H2BC21 H2B clustered histone 21 2.03083
GADD45B growth arrest and DNA-damage-inducible, beta 2.01961
H2AC6 H2A clustered histone 6 2.0079
C1QB complement component 1, q subcomponent, B chain 2.0022

decreased expression

Symbol Name Standardized Value
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -5.95519
RPA3 replication protein A3, 14kDa -4.52963
TM9SF3 transmembrane 9 superfamily member 3 -3.72343
CCNB1 cyclin B1 -3.68046
PROM1 prominin 1 -3.56827
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -3.35073
UBE2S ubiquitin-conjugating enzyme E2S -3.06589
CDCA4 cell division cycle associated 4 -2.87891
DCK deoxycytidine kinase -2.79441
SLC66A2 solute carrier family 66 member 2 -2.78946
INTS15 integrator complex subunit 15 -2.75518
APOA2 apolipoprotein A-II -2.75284
SCCPDH saccharopine dehydrogenase (putative) -2.74179
NT5DC2 5'-nucleotidase domain containing 2 -2.72814
DMTN dematin actin binding protein -2.70655
H2AX H2A.X variant histone -2.64429
RFC3 replication factor C (activator 1) 3, 38kDa -2.63806
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.57333
S100P S100 calcium binding protein P -2.5486
INTS9 integrator complex subunit 9 -2.45944
HBQ1 hemoglobin, theta 1 -2.4456
ADI1 acireductone dioxygenase 1 -2.41789
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.41635
AHCY adenosylhomocysteinase -2.40483
RHOB ras homolog family member B -2.40291
TUBG1 tubulin, gamma 1 -2.39634
CCNE1 cyclin E1 -2.35475
COXFA4 cytochrome c oxidase associated subunit FA4 -2.35452
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.33736
RPS5 ribosomal protein S5 -2.30686
NCAPG2 non-SMC condensin II complex, subunit G2 -2.305
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.295
DNASE1L3 deoxyribonuclease I-like 3 -2.26913
PHYH phytanoyl-CoA 2-hydroxylase -2.26885
TOR3A torsin family 3, member A -2.26396
PUF60 poly-U binding splicing factor 60KDa -2.26143
ANKRD44 ankyrin repeat domain 44 -2.24759
COX5A cytochrome c oxidase subunit Va -2.23706
SLC68A1 solute carrier family 68 member 1 -2.2048
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 -2.18567
CCNA2 cyclin A2 -2.18521
MCM6 minichromosome maintenance complex component 6 -2.18399
COX5B cytochrome c oxidase subunit Vb -2.18304
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.16596
PBK PDZ binding kinase -2.16398
ZNF12 zinc finger protein 12 -2.15156
TRAT1 T cell receptor associated transmembrane adaptor 1 -2.12729
ETFB electron-transfer-flavoprotein, beta polypeptide -2.12065
ASF1B anti-silencing function 1B histone chaperone -2.11776
RPL38 ribosomal protein L38 -2.09593
THEM6 thioesterase superfamily member 6 -2.08672
SPIB Spi-B transcription factor (Spi-1/PU.1 related) -2.07576
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) -2.07214
ATP6V0E2 ATPase, H+ transporting V0 subunit e2 -2.05852
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -2.05549
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -2.05484
CALM2 calmodulin 2 (phosphorylase kinase, delta) -2.04462
PRC1 protein regulator of cytokinesis 1 -2.03501
SLC30A10 solute carrier family 30, member 10 -2.03321
ZDHHC4 zinc finger, DHHC-type containing 4 -2.03176
HADH hydroxyacyl-CoA dehydrogenase -2.03079
TRIP13 thyroid hormone receptor interactor 13 -2.0268
CDC45 cell division cycle 45 -2.01385
UQCRH ubiquinol-cytochrome c reductase hinge protein -2.01046
MCF2L MCF.2 cell line derived transforming sequence-like -2.00349