CRCGN015_HEPG2_48H:J20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description simazine 34.02 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

58 genes differentially expressed following the CRCGN015_HEPG2_48H:J20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 4.03952
SNX11 sorting nexin 11 3.85646
FPGS folylpolyglutamate synthase 3.38802
PPARG peroxisome proliferator-activated receptor gamma 3.06369
GSTM2 glutathione S-transferase mu 2 (muscle) 2.77146
PLA2G3 phospholipase A2, group III 2.74032
MAMLD1 mastermind-like domain containing 1 2.73718
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.66261
ISG15 ISG15 ubiquitin-like modifier 2.60147
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 2.52103
TUBA1C tubulin, alpha 1c 2.33639
EAPP E2F-associated phosphoprotein 2.33108
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.31841
OCEL1 occludin/ELL domain containing 1 2.28429
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 2.27027
GPER1 G protein-coupled estrogen receptor 1 2.23687
PEAK1 pseudopodium-enriched atypical kinase 1 2.2312
CTF1 cardiotrophin 1 2.21129
CHAD chondroadherin 2.2108
MTM1 myotubularin 1 2.17071
MCUR1 mitochondrial calcium uniporter regulator 1 2.1467
AP5S1 adaptor-related protein complex 5, sigma 1 subunit 2.14452
SPIN2B spindlin family, member 2B 2.13899
MICA MHC class I polypeptide-related sequence A 2.13
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 2.11799
DCTPP1 dCTP pyrophosphatase 1 2.10319
TMEM14B transmembrane protein 14B 2.09968
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 2.0605
SCAND1 SCAN domain containing 1 2.05961
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.05196
SASH3 SAM and SH3 domain containing 3 2.04537
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 2.03618
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 2.03391
RPS12 ribosomal protein S12 2.03058
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 2.02388
GRIP2 glutamate receptor interacting protein 2 2.02214
BPIFA1 BPI fold containing family A, member 1 2.022
GREB1L growth regulation by estrogen in breast cancer-like 2.0096

decreased expression

Symbol Name Standardized Value
CXADR coxsackie virus and adenovirus receptor -4.83691
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -3.44221
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.22038
PUF60 poly-U binding splicing factor 60KDa -3.13672
MT1X metallothionein 1X -3.04751
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -3.00473
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.94401
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -2.93021
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.74429
RBM34 RNA binding motif protein 34 -2.43549
LOC124907782 dual specificity protein phosphatase 22 -2.3509
STAT1 signal transducer and activator of transcription 1, 91kDa -2.34649
GGPS1 geranylgeranyl diphosphate synthase 1 -2.32907
STIP1 stress-induced phosphoprotein 1 -2.24886
ANXA3 annexin A3 -2.18821
LIMK2 LIM domain kinase 2 -2.18788
LOC124905743 low affinity immunoglobulin gamma Fc region receptor III-B -2.17493
CSRP2 cysteine and glycine-rich protein 2 -2.10765
ACKR3 atypical chemokine receptor 3 -2.01564
HCAR3 hydroxycarboxylic acid receptor 3 -2.01125