CRCGN015_HEPG2_48H:K11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description wortmannin 3.33 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

99 genes differentially expressed following the CRCGN015_HEPG2_48H:K11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PLEKHJ1 pleckstrin homology domain containing, family J member 1 5.89653
EPN2 epsin 2 3.42876
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.39789
PRODH2 proline dehydrogenase (oxidase) 2 2.93896
HAGH hydroxyacylglutathione hydrolase 2.78773
FTCD formimidoyltransferase cyclodeaminase 2.75157
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7 2.74935
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.66247
GTPBP8 GTP-binding protein 8 (putative) 2.55484
BDH1 3-hydroxybutyrate dehydrogenase, type 1 2.51516
PECR peroxisomal trans-2-enoyl-CoA reductase 2.51221
BHMT betaine--homocysteine S-methyltransferase 2.49473
PRR7 proline rich 7 (synaptic) 2.47981
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 2.47891
ULK2 unc-51 like autophagy activating kinase 2 2.44791
VIPR1 vasoactive intestinal peptide receptor 1 2.43644
ACSM5 acyl-CoA synthetase medium-chain family member 5 2.42591
GPR27 G protein-coupled receptor 27 2.40797
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2.3257
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.2856
EPHA4 EPH receptor A4 2.27869
APOF apolipoprotein F 2.26415
LGMN legumain 2.26099
FAIM2 Fas apoptotic inhibitory molecule 2 2.25019
HAAO 3-hydroxyanthranilate 3,4-dioxygenase 2.23749
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.23646
GYS2 glycogen synthase 2 (liver) 2.22542
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 2.21766
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.2167
VAV3 vav 3 guanine nucleotide exchange factor 2.204
OCA2 oculocutaneous albinism II 2.20243
GPR162 G protein-coupled receptor 162 2.19855
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 2.19453
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 2.17364
TKFC triokinase/FMN cyclase 2.1695
EPHX2 epoxide hydrolase 2, cytoplasmic 2.16643
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 2.16302
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.1618
PBLD phenazine biosynthesis-like protein domain containing 2.15705
SLC17A2 solute carrier family 17, member 2 2.15233
KDM8 lysine (K)-specific demethylase 8 2.14994
UNC119 unc-119 homolog (C. elegans) 2.14896
CERS4 ceramide synthase 4 2.14785
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 2.14575
ADAMTSL3 ADAMTS-like 3 2.14125
NHERF4 NHERF family PDZ scaffold protein 4 2.1378
SGPP2 sphingosine-1-phosphate phosphatase 2 2.13542
RAB17 RAB17, member RAS oncogene family 2.11901
RGN regucalcin 2.1104
ZNF696 zinc finger protein 696 2.10783
MRPL44 mitochondrial ribosomal protein L44 2.1002
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) 2.08916
MXD3 MAX dimerization protein 3 2.08778
ZNF747 zinc finger protein 747 2.08711
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 2.08646
TRIM52 tripartite motif containing 52 2.07468
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 2.06821
OPCML opioid binding protein/cell adhesion molecule-like 2.06623
CTXND1 cortexin domain containing 1 2.06225
ZNF552 zinc finger protein 552 2.05303
STAT5B signal transducer and activator of transcription 5B 2.05175
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.0514
NANOG Nanog homeobox 2.04773
SLC66A2 solute carrier family 66 member 2 2.04227
TTC38 tetratricopeptide repeat domain 38 2.03643
GCDH glutaryl-CoA dehydrogenase 2.03095
AMT aminomethyltransferase 2.0305
HGFAC HGF activator 2.03016
CA5A carbonic anhydrase VA, mitochondrial 2.01337
CDK20 cyclin-dependent kinase 20 2.00772
SPTBN2 spectrin, beta, non-erythrocytic 2 2.00706
LOC102724652 alpha-crystallin A chain 2.00676
GDF2 growth differentiation factor 2 2.00528
HPN hepsin 2.00313
LRRC61 leucine rich repeat containing 61 2.00212
NCAN neurocan 2.00082

decreased expression

Symbol Name Standardized Value
S100P S100 calcium binding protein P -3.86511
IER3 immediate early response 3 -3.44369
TRIB1 tribbles pseudokinase 1 -2.89429
YY1AP1 YY1 associated protein 1 -2.77296
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.71857
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.54441
VAT1 vesicle amine transport 1 -2.52254
MCM3 minichromosome maintenance complex component 3 -2.40322
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.37184
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa -2.36597
ASXL2 additional sex combs like transcriptional regulator 2 -2.30734
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) -2.30592
IARS1 isoleucyl-tRNA synthetase 1 -2.24511
AATF apoptosis antagonizing transcription factor -2.20486
BHLHE40 basic helix-loop-helix family, member e40 -2.17647
KLC1 kinesin light chain 1 -2.12794
JPT1 Jupiter microtubule associated homolog 1 -2.09607
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -2.07316
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.04571
BYSL bystin-like -2.04202
LOC112694756 uncharaterized LOC112694756 -2.02783
KEAP1 kelch-like ECH-associated protein 1 -2.01169
TARS1 threonyl-tRNA synthetase 1 -2.00925