CRCGN015_HEPG2_48H:K12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description wortmannin 1.11 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN015_HEPG2_48H:K12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INTS3 integrator complex subunit 3 5.12495
SMIM40 small integral membrane protein 40 4.30094
PRR7 proline rich 7 (synaptic) 4.16058
GABPB1 GA binding protein transcription factor, beta subunit 1 3.29237
IL4R interleukin 4 receptor 3.26184
KIFC1 kinesin family member C1 3.05609
HYOU1 hypoxia up-regulated 1 2.92655
PBLD phenazine biosynthesis-like protein domain containing 2.91959
MSH5 mutS homolog 5 2.56915
PEX11A peroxisomal biogenesis factor 11 alpha 2.5639
SQOR sulfide quinone oxidoreductase 2.33644
MXD3 MAX dimerization protein 3 2.33194
FANCI Fanconi anemia, complementation group I 2.27954
PDLIM1 PDZ and LIM domain 1 2.26367
CDK18 cyclin-dependent kinase 18 2.26131
IGHMBP2 immunoglobulin mu binding protein 2 2.22437
ACP5 acid phosphatase 5, tartrate resistant 2.22068
RECQL4 RecQ protein-like 4 2.15878
CENPU centromere protein U 2.1582
PVRIG poliovirus receptor related immunoglobulin domain containing 2.09896
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.07376
BAMBI BMP and activin membrane-bound inhibitor 2.07051
FANCG Fanconi anemia, complementation group G 2.04728
SNX10 sorting nexin 10 2.04015
ACP2 acid phosphatase 2, lysosomal 2.01228
FAAP24 FA core complex associated protein 24 2.01067

decreased expression

Symbol Name Standardized Value
S100P S100 calcium binding protein P -7.72831
MCUR1 mitochondrial calcium uniporter regulator 1 -4.65713
EIF5 eukaryotic translation initiation factor 5 -4.33347
BIRC2 baculoviral IAP repeat containing 2 -3.89719
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.51538
MT1X metallothionein 1X -3.42448
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.22202
TRIB1 tribbles pseudokinase 1 -2.90408
IER3 immediate early response 3 -2.88554
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.72408
YAP1 Yes-associated protein 1 -2.45161
FAT1 FAT atypical cadherin 1 -2.42525
LASP1 LIM and SH3 protein 1 -2.31959
LOC124907782 dual specificity protein phosphatase 22 -2.29672
RHOB ras homolog family member B -2.25588
SNX16 sorting nexin 16 -2.13944
GDE1 glycerophosphodiester phosphodiesterase 1 -2.09041
KPNA4 karyopherin alpha 4 (importin alpha 3) -2.08856
NOP14 NOP14 nucleolar protein -2.08599
MAP4 microtubule-associated protein 4 -2.08539
NOP16 NOP16 nucleolar protein -2.06944
BHLHE40 basic helix-loop-helix family, member e40 -2.05587
TBX3 T-box 3 -2.04981
SLC35F2 solute carrier family 35, member F2 -2.03658