CRCGN015_HEPG2_48H:K18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description isobutyraldehyde 11.31 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN015_HEPG2_48H:K18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MCOLN1 mucolipin 1 5.1783
SCRN1 secernin 1 3.94018
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.31253
LGMN legumain 3.30496
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.21792
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.91746
GTPBP8 GTP-binding protein 8 (putative) 2.87022
LSR lipolysis stimulated lipoprotein receptor 2.80242
NANOG Nanog homeobox 2.72198
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 2.7148
NOSIP nitric oxide synthase interacting protein 2.70129
ADAT1 adenosine deaminase, tRNA-specific 1 2.66485
CLASRP CLK4-associating serine/arginine rich protein 2.59347
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.47463
FOXH1 forkhead box H1 2.3173
PTK2B protein tyrosine kinase 2 beta 2.31617
SYK spleen tyrosine kinase 2.30561
TAGLN3 transgelin 3 2.27818
CAPN6 calpain 6 2.27709
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.2739
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.24067
SIRT1 sirtuin 1 2.22535
FZD1 frizzled class receptor 1 2.1955
PRR7 proline rich 7 (synaptic) 2.19001
CORO1A coronin, actin binding protein, 1A 2.18439
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2.17099
SNX7 sorting nexin 7 2.16164
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.15852
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) 2.1558
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.15343
GDAP1 ganglioside induced differentiation associated protein 1 2.1352
POGLUT1 protein O-glucosyltransferase 1 2.13295
BRS3 bombesin-like receptor 3 2.1108
PRDM5 PR domain containing 5 2.09945
LYN LYN proto-oncogene, Src family tyrosine kinase 2.09487
ADPRH ADP-ribosylarginine hydrolase 2.0947
FGR FGR proto-oncogene, Src family tyrosine kinase 2.08679
OXR1 oxidation resistance 1 2.07999
PDE1B phosphodiesterase 1B, calmodulin-dependent 2.07437
ZIM3 zinc finger, imprinted 3 2.06416
CD8A CD8a molecule 2.05342
IL2RB interleukin 2 receptor, beta 2.04985
MYL9 myosin, light chain 9, regulatory 2.04737
R3HCC1L R3H domain and coiled-coil containing 1-like 2.03904
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 2.0315
GNA13 guanine nucleotide binding protein (G protein), alpha 13 2.0264
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 2.01423
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 2.01191
UTF1 undifferentiated embryonic cell transcription factor 1 2.00038

decreased expression

Symbol Name Standardized Value
PCCB propionyl CoA carboxylase, beta polypeptide -4.58605
FASTKD5 FAST kinase domains 5 -3.62192
KEAP1 kelch-like ECH-associated protein 1 -3.54833
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.90074
LOC124907782 dual specificity protein phosphatase 22 -2.83488
DCTN3 dynactin 3 (p22) -2.35071
MT1X metallothionein 1X -2.32499
CUEDC2 CUE domain containing 2 -2.27778
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) -2.2288
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B -2.18522