CRCGN015_HEPG2_48H:L13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description etodolac 99.8 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN015_HEPG2_48H:L13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAP7 microtubule-associated protein 7 4.73343
SLC75A1 solute carrier family 75 member 1 4.01273
LAGE3 L antigen family, member 3 3.79095
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.62367
EXOSC4 exosome component 4 2.73886
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 2.23308
QDPR quinoid dihydropteridine reductase 2.20881
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase 2.20142
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa 2.16107
ECHDC1 ethylmalonyl-CoA decarboxylase 1 2.12405
SLC16A6 solute carrier family 16, member 6 2.11263
MTUS1 microtubule associated tumor suppressor 1 2.10434
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 2.04425
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 2.02936
CDK18 cyclin-dependent kinase 18 2.01983

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.31141
NUP85 nucleoporin 85kDa -4.80605
SAP30BP SAP30 binding protein -4.74507
JPT1 Jupiter microtubule associated homolog 1 -4.51192
KCTD2 potassium channel tetramerization domain containing 2 -4.46
HEATR1 HEAT repeat containing 1 -4.35297
MRPL58 mitochondrial ribosomal protein L58 -4.0178
MT1X metallothionein 1X -3.51211
MRPS7 mitochondrial ribosomal protein S7 -3.31533
CASKIN2 CASK interacting protein 2 -3.09215
SUMO4 small ubiquitin-like modifier 4 -3.06423
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.80867
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -2.69217
TM9SF3 transmembrane 9 superfamily member 3 -2.46903
GRB2 growth factor receptor-bound protein 2 -2.44738
TTI1 TELO2 interacting protein 1 -2.37872
RNF111 ring finger protein 111 -2.21855
LRRC42 leucine rich repeat containing 42 -2.1903
CDR2L cerebellar degeneration-related protein 2-like -2.17417
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 -2.12153
RPAP1 RNA polymerase II associated protein 1 -2.04816
PTN pleiotrophin -2.04128
ATP5PD ATP synthase peripheral stalk subunit d -2.04062
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5 -2.0352
GREB1L growth regulation by estrogen in breast cancer-like -2.02888