CRCGN015_HEPG2_48H:L21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dichlorobenzidine 10.75 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

285 genes differentially expressed following the CRCGN015_HEPG2_48H:L21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 8.15386
TRIB1 tribbles pseudokinase 1 4.74402
IL4R interleukin 4 receptor 4.71226
FOSL1 FOS-like antigen 1 4.33955
IER3 immediate early response 3 4.32003
EGR1 early growth response 1 4.11562
BLCAP bladder cancer associated protein 3.96319
FHL2 four and a half LIM domains 2 3.82388
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.77746
INPP1 inositol polyphosphate-1-phosphatase 3.71212
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.54744
TIGAR TP53 induced glycolysis regulatory phosphatase 3.4828
TUBB6 tubulin, beta 6 class V 3.45553
MAPK13 mitogen-activated protein kinase 13 3.37319
TLR4 toll-like receptor 4 3.22995
DUSP6 dual specificity phosphatase 6 3.21098
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.19323
PHC2 polyhomeotic homolog 2 (Drosophila) 3.12826
H2BC21 H2B clustered histone 21 3.10089
ANO10 anoctamin 10 3.09818
EPHA2 EPH receptor A2 3.06941
TERF2IP telomeric repeat binding factor 2, interacting protein 3.04222
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 3.03997
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.99948
RAP1GAP2 RAP1 GTPase activating protein 2 2.94995
ZMAT3 zinc finger, matrin-type 3 2.92764
SQSTM1 sequestosome 1 2.90241
SMIM44 small integral membrane protein 44 2.85742
AEN apoptosis enhancing nuclease 2.85565
MINDY1 MINDY lysine 48 deubiquitinase 1 2.84566
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.82773
DDB2 damage-specific DNA binding protein 2, 48kDa 2.81187
SOX4 SRY (sex determining region Y)-box 4 2.7735
RALGDS ral guanine nucleotide dissociation stimulator 2.75967
CHIC2 cysteine-rich hydrophobic domain 2 2.75658
JPT1 Jupiter microtubule associated homolog 1 2.74193
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.74096
CEMIP2 cell migration inducing hyaluronidase 2 2.70321
LRP10 low density lipoprotein receptor-related protein 10 2.66322
ATG4A autophagy related 4A, cysteine peptidase 2.66076
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.65614
LOC102724023 ES1 protein homolog, mitochondrial 2.63907
ZNF562 zinc finger protein 562 2.62525
BTG2 BTG family, member 2 2.61576
DSG2 desmoglein 2 2.59671
MKNK2 MAP kinase interacting serine/threonine kinase 2 2.57595
RALB v-ral simian leukemia viral oncogene homolog B 2.5382
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.52968
REXO2 RNA exonuclease 2 2.52443
FASN fatty acid synthase 2.52315
CTSL cathepsin L 2.51787
PLSCR3 phospholipid scramblase 3 2.48483
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 2.48407
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.4688
IGF2R insulin-like growth factor 2 receptor 2.45508
MACF1 microtubule-actin crosslinking factor 1 2.45374
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 2.45082
TOR1B torsin family 1, member B (torsin B) 2.41125
ABHD5 abhydrolase domain containing 5 2.4025
TRIAP1 TP53 regulated inhibitor of apoptosis 1 2.35616
LIF leukemia inhibitory factor 2.3553
FAM222B family with sequence similarity 222, member B 2.35485
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.35279
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 2.34384
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.3242
MX2 MX dynamin-like GTPase 2 2.30619
TP53I3 tumor protein p53 inducible protein 3 2.29015
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.28836
SLC35F2 solute carrier family 35, member F2 2.28614
LSG1 large 60S subunit nuclear export GTPase 1 2.28387
IL6 interleukin 6 2.26024
MBNL2 muscleblind-like splicing regulator 2 2.22957
CSRNP2 cysteine-serine-rich nuclear protein 2 2.22923
MMP24-AS1-EDEM2 MMP24-AS1-EDEM2 readthrough 2.21628
NOTCH1 notch 1 2.21232
STX3 syntaxin 3 2.20789
UFM1 ubiquitin-fold modifier 1 2.20158
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 2.20112
ISG20 interferon stimulated exonuclease gene 20kDa 2.20048
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.18596
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 2.18265
TXNRD1 thioredoxin reductase 1 2.17094
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.16769
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 2.15106
BECN1 beclin 1, autophagy related 2.14417
ITGA6 integrin, alpha 6 2.14031
RMC1 regulator of MON1-CCZ1 2.12137
TRIM8 tripartite motif containing 8 2.12116
CLDN4 claudin 4 2.12084
KIF3B kinesin family member 3B 2.11963
FDXR ferredoxin reductase 2.11831
NXPE3 neurexophilin and PC-esterase domain family, member 3 2.11766
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.11218
TUT7 terminal uridylyl transferase 7 2.10355
COLGALT2 collagen beta(1-O)galactosyltransferase 2 2.09783
RNF103 ring finger protein 103 2.09556
SETBP1 SET binding protein 1 2.09455
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 2.09305
NCOA1 nuclear receptor coactivator 1 2.09044
IL32 interleukin 32 2.08982
COL17A1 collagen, type XVII, alpha 1 2.08926
ATF5 activating transcription factor 5 2.08866
MZB1 marginal zone B and B1 cell-specific protein 2.08309
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 2.08089
CPM carboxypeptidase M 2.07171
KLF7 Kruppel-like factor 7 (ubiquitous) 2.07101
POU2AF1 POU class 2 associating factor 1 2.06784
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 2.0631
ELL2 elongation factor, RNA polymerase II, 2 2.05243
GADD45A growth arrest and DNA-damage-inducible, alpha 2.05179
CDA cytidine deaminase 2.04963
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 2.04868
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 2.03355
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 2.03296
KLF3 Kruppel-like factor 3 (basic) 2.03233
PMP22 peripheral myelin protein 22 2.02312
AIM2 absent in melanoma 2 2.02301
TMEM140 transmembrane protein 140 2.01278
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.00979

decreased expression

Symbol Name Standardized Value
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -4.95497
HADH hydroxyacyl-CoA dehydrogenase -4.84245
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.55522
ADI1 acireductone dioxygenase 1 -4.35806
PECR peroxisomal trans-2-enoyl-CoA reductase -4.21795
APOH apolipoprotein H (beta-2-glycoprotein I) -3.90759
APOA2 apolipoprotein A-II -3.85276
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.73844
SOAT2 sterol O-acyltransferase 2 -3.57767
CDC20 cell division cycle 20 -3.38565
MRPL12 mitochondrial ribosomal protein L12 -3.37118
MPC2 mitochondrial pyruvate carrier 2 -3.36348
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.28354
ISOC1 isochorismatase domain containing 1 -3.27454
STMN1 stathmin 1 -3.22291
MCM3 minichromosome maintenance complex component 3 -3.21367
CETN3 centrin, EF-hand protein, 3 -3.2127
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.16585
MSMO1 methylsterol monooxygenase 1 -3.16511
RPA3 replication protein A3, 14kDa -3.14715
CCNA2 cyclin A2 -3.09192
ALDOC aldolase C, fructose-bisphosphate -3.05971
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -3.03934
PTOV1 prostate tumor overexpressed 1 -3.01622
PGM1 phosphoglucomutase 1 -3.00898
AURKB aurora kinase B -2.98789
PSRC1 proline/serine-rich coiled-coil 1 -2.97679
MCM5 minichromosome maintenance complex component 5 -2.94034
ELP4 elongator acetyltransferase complex subunit 4 -2.93653
PYCR1 pyrroline-5-carboxylate reductase 1 -2.92877
SPC25 SPC25, NDC80 kinetochore complex component -2.9204
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -2.88121
HMGA2 high mobility group AT-hook 2 -2.87805
RSU1 Ras suppressor protein 1 -2.86929
MVD mevalonate (diphospho) decarboxylase -2.85411
SRP9 signal recognition particle 9kDa -2.85356
BIRC5 baculoviral IAP repeat containing 5 -2.83964
TM9SF3 transmembrane 9 superfamily member 3 -2.83347
OIP5 Opa interacting protein 5 -2.82798
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.80825
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.80244
SQLE squalene epoxidase -2.73176
PLK1 polo-like kinase 1 -2.71968
CDT1 chromatin licensing and DNA replication factor 1 -2.71727
PPA2 pyrophosphatase (inorganic) 2 -2.71077
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.67278
PNKP polynucleotide kinase 3'-phosphatase -2.66723
DHCR7 7-dehydrocholesterol reductase -2.65678
PCYT2 phosphate cytidylyltransferase 2, ethanolamine -2.64989
APOM apolipoprotein M -2.64723
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.63075
TEDC2 tubulin epsilon and delta complex 2 -2.62385
KIFC1 kinesin family member C1 -2.57141
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 -2.57004
SCARA3 scavenger receptor class A, member 3 -2.55307
DMAC2L distal membrane arm assembly component 2 like -2.54471
RNASE4 ribonuclease, RNase A family, 4 -2.53821
ARL6IP4 ADP-ribosylation factor-like 6 interacting protein 4 -2.52714
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.51979
MTREX Mtr4 exosome RNA helicase -2.51151
DUT deoxyuridine triphosphatase -2.49223
PPIH peptidylprolyl isomerase H (cyclophilin H) -2.47743
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -2.46361
PEX11A peroxisomal biogenesis factor 11 alpha -2.4521
TM7SF2 transmembrane 7 superfamily member 2 -2.4363
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -2.41373
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) -2.41253
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.40035
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.39618
FADS2 fatty acid desaturase 2 -2.39009
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.3871
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.3848
FAIM Fas apoptotic inhibitory molecule -2.38424
FN3KRP fructosamine 3 kinase related protein -2.38387
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.3756
NCAPD3 non-SMC condensin II complex, subunit D3 -2.36811
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -2.36036
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.35792
MCMBP minichromosome maintenance complex binding protein -2.35047
GCAT glycine C-acetyltransferase -2.3482
GYG2 glycogenin 2 -2.34815
RAB4A RAB4A, member RAS oncogene family -2.34127
SREBF2 sterol regulatory element binding transcription factor 2 -2.33509
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 -2.32721
DHFR dihydrofolate reductase -2.32422
CPB2 carboxypeptidase B2 (plasma) -2.32402
ZNF83 zinc finger protein 83 -2.32265
LBR lamin B receptor -2.30921
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa -2.30072
MSH5 mutS homolog 5 -2.29831
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.28719
MAGED1 melanoma antigen family D1 -2.28476
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.27956
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.27029
MOCS2 molybdenum cofactor synthesis 2 -2.27012
UQCRC1 ubiquinol-cytochrome c reductase core protein I -2.26785
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.26454
VEGFB vascular endothelial growth factor B -2.26067
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -2.25756
DCK deoxycytidine kinase -2.25678
RIDA reactive intermediate imine deaminase A homolog -2.25538
GCDH glutaryl-CoA dehydrogenase -2.24646
GPS1 G protein pathway suppressor 1 -2.23832
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.23008
MRPL16 mitochondrial ribosomal protein L16 -2.22803
GJB1 gap junction protein, beta 1, 32kDa -2.21881
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -2.21794
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.21396
TRMT5 tRNA methyltransferase 5 -2.2119
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase -2.20463
HDAC3 histone deacetylase 3 -2.20059
TMA16 translation machinery associated 16 homolog (S. cerevisiae) -2.20034
EXO1 exonuclease 1 -2.1952
MTG1 mitochondrial ribosome-associated GTPase 1 -2.18866
HMGB2 high mobility group box 2 -2.18612
COPS4 COP9 signalosome subunit 4 -2.18475
HIKESHI heat shock protein nuclear import factor hikeshi -2.18087
CCNB2 cyclin B2 -2.17424
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.17261
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 -2.16799
RFC2 replication factor C (activator 1) 2, 40kDa -2.16633
AAAS achalasia, adrenocortical insufficiency, alacrimia -2.15896
GRHPR glyoxylate reductase/hydroxypyruvate reductase -2.1563
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.15134
MAT1A methionine adenosyltransferase I, alpha -2.1503
TTK TTK protein kinase -2.14723
HACL2 2-hydroxyacyl-CoA lyase 2 -2.14135
NCKIPSD NCK interacting protein with SH3 domain -2.13931
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.13408
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 -2.12621
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 -2.12465
CDC45 cell division cycle 45 -2.11934
MAGOHB mago-nashi homolog B (Drosophila) -2.11352
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 -2.1131
GALT galactose-1-phosphate uridylyltransferase -2.11063
CETN2 centrin, EF-hand protein, 2 -2.1063
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.10487
PRR3 proline rich 3 -2.10216
ANAPC15 anaphase promoting complex subunit 15 -2.10033
CD207 CD207 molecule, langerin -2.09846
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 -2.09055
ATP5PF ATP synthase peripheral stalk subunit F6 -2.08333
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -2.07609
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 -2.07322
TEX30 testis expressed 30 -2.07232
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -2.0717
COQ3 coenzyme Q3 methyltransferase -2.06886
KIF20A kinesin family member 20A -2.0623
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -2.06192
NME4 NME/NM23 nucleoside diphosphate kinase 4 -2.05212
PHKB phosphorylase kinase, beta -2.04915
SNRPA small nuclear ribonucleoprotein polypeptide A -2.04667
SNX5 sorting nexin 5 -2.04002
CD5L CD5 molecule-like -2.03808
APEH acylaminoacyl-peptide hydrolase -2.03684
ADISSP adipose secreted signaling protein -2.0313
CDC25C cell division cycle 25C -2.0301
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -2.02734
CARHSP1 calcium regulated heat stable protein 1, 24kDa -2.02544
ZBTB5 zinc finger and BTB domain containing 5 -2.0156
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) -2.01537
PHGDH phosphoglycerate dehydrogenase -2.01012
SLC17A2 solute carrier family 17, member 2 -2.00908
PYDC1 PYD (pyrin domain) containing 1 -2.00599
KIF11 kinesin family member 11 -2.00469
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B -2.00426