CRCGN015_HEPG2_48H:M14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dichloroethane 32.27 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

29 genes differentially expressed following the CRCGN015_HEPG2_48H:M14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 3.59624
SIRT3 sirtuin 3 2.93793
SCAND1 SCAN domain containing 1 2.5781
HOMER2 homer scaffolding protein 2 2.2634
MYL9 myosin, light chain 9, regulatory 2.23823
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 2.143
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 2.13065
EIF4A3 eukaryotic translation initiation factor 4A3 2.12437
NAP1L4 nucleosome assembly protein 1-like 4 2.11827
UQCRC1 ubiquinol-cytochrome c reductase core protein I 2.10359
PRMT7 protein arginine methyltransferase 7 2.08945
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 2.07081
CKB creatine kinase, brain 2.05271
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.03619

decreased expression

Symbol Name Standardized Value
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -4.72938
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.3969
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -4.0964
VDAC1 voltage-dependent anion channel 1 -4.09352
HEATR1 HEAT repeat containing 1 -3.87248
TFRC transferrin receptor -3.10325
NME1 NME/NM23 nucleoside diphosphate kinase 1 -2.76106
MORC4 MORC family CW-type zinc finger 4 -2.62267
MT1X metallothionein 1X -2.3738
HSPA9 heat shock 70kDa protein 9 (mortalin) -2.34883
FHIT fragile histidine triad -2.31899
TEX10 testis expressed 10 -2.09552
ADAMTSL3 ADAMTS-like 3 -2.05627
TEC tec protein tyrosine kinase -2.02204
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 -2.00161