CRCGN015_HEPG2_48H:M15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dichloroethane 10.76 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN015_HEPG2_48H:M15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.42746
CEPT1 choline/ethanolamine phosphotransferase 1 3.24333
COQ8A coenzyme Q8A 2.61287
SAR1B secretion associated, Ras related GTPase 1B 2.52508
NUTF2 nuclear transport factor 2 2.50874
COMMD3 COMM domain containing 3 2.39315
MED18 mediator complex subunit 18 2.37129
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa 2.3516
SSUH2 ssu-2 homolog (C. elegans) 2.33917
ZNF124 zinc finger protein 124 2.32471
SELPLG selectin P ligand 2.29722
MRPL58 mitochondrial ribosomal protein L58 2.25996
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa 2.22317
RBBP5 retinoblastoma binding protein 5 2.21717
C1GALT1C1 C1GALT1-specific chaperone 1 2.19973
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.18411
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 2.17786
MTA2 metastasis associated 1 family, member 2 2.1723
RANBP6 RAN binding protein 6 2.15995
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 2.12821
CPPED1 calcineurin-like phosphoesterase domain containing 1 2.12047
ATRAID all-trans retinoic acid-induced differentiation factor 2.118
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.11297
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 2.08357
NEK3 NIMA-related kinase 3 2.07762
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 2.07706
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.0756
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 2.0542
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1 2.03909
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 2.03391
STRN3 striatin, calmodulin binding protein 3 2.02409
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.02028
CCL16 chemokine (C-C motif) ligand 16 2.00775

decreased expression

Symbol Name Standardized Value
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -4.91023
MT1X metallothionein 1X -4.82003
HEATR1 HEAT repeat containing 1 -4.60386
S100P S100 calcium binding protein P -4.52444
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F -4.27859
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.73478
LDHD lactate dehydrogenase D -3.58044
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.33448
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -3.19112
TM9SF3 transmembrane 9 superfamily member 3 -2.95423
VAT1 vesicle amine transport 1 -2.931
CHGB chromogranin B -2.56225
CSRP2 cysteine and glycine-rich protein 2 -2.55437
TP53BP2 tumor protein p53 binding protein 2 -2.48066
LINC02762 long intergenic non-protein coding RNA 2762 -2.44522
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.43586
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -2.34309
F3 coagulation factor III (thromboplastin, tissue factor) -2.21634
CAPN15 calpain 15 -2.21304
SAMD4B sterile alpha motif domain containing 4B -2.15651
IL7R interleukin 7 receptor -2.11581
SLIT2 slit homolog 2 (Drosophila) -2.07506
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -2.07243
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) -2.0599
CBX7 chromobox homolog 7 -2.04786
FGF9 fibroblast growth factor 9 -2.0207
RNF187 ring finger protein 187 -2.00261