CRCGN015_HEPG2_48H:M18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cadmium chloride 11.14 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

190 genes differentially expressed following the CRCGN015_HEPG2_48H:M18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
FHL2 four and a half LIM domains 2 4.8007
MAMLD1 mastermind-like domain containing 1 4.52423
SOX4 SRY (sex determining region Y)-box 4 3.88534
FAT1 FAT atypical cadherin 1 3.84916
SQOR sulfide quinone oxidoreductase 3.70974
TOMM34 translocase of outer mitochondrial membrane 34 3.4119
TRIB1 tribbles pseudokinase 1 3.37524
CLTB clathrin, light chain B 3.29148
SLC35F2 solute carrier family 35, member F2 3.19131
TUBB6 tubulin, beta 6 class V 3.14084
MINDY1 MINDY lysine 48 deubiquitinase 1 3.13115
VAMP8 vesicle-associated membrane protein 8 3.12098
BMP4 bone morphogenetic protein 4 2.98687
S100A4 S100 calcium binding protein A4 2.8648
STIMATE STIM activating enhancer 2.81927
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 2.80546
GGT5 gamma-glutamyltransferase 5 2.68997
EDN1 endothelin 1 2.6841
CST1 cystatin SN 2.68232
PHC2 polyhomeotic homolog 2 (Drosophila) 2.67383
IGFBP4 insulin-like growth factor binding protein 4 2.66263
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 2.63912
MAPK13 mitogen-activated protein kinase 13 2.62613
FOSL1 FOS-like antigen 1 2.58188
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 2.55701
CEMIP2 cell migration inducing hyaluronidase 2 2.55459
CST2 cystatin SA 2.54101
IER3 immediate early response 3 2.51251
KIFBP kinesin family binding protein 2.4929
BACE2 beta-site APP-cleaving enzyme 2 2.41513
CST4 cystatin S 2.36595
MFSD1 major facilitator superfamily domain containing 1 2.36528
GABARAP GABA(A) receptor-associated protein 2.36144
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2.35136
C1GALT1C1 C1GALT1-specific chaperone 1 2.34197
RTF2 replication termination factor 2 2.33195
CDPF1 cysteine-rich, DPF motif domain containing 1 2.3023
BATF basic leucine zipper transcription factor, ATF-like 2.2884
GRB10 growth factor receptor-bound protein 10 2.28723
JPT1 Jupiter microtubule associated homolog 1 2.27608
MVP major vault protein 2.27568
GBA1 glucosylceramidase beta 1 2.25765
ACOT9 acyl-CoA thioesterase 9 2.23634
PIGT phosphatidylinositol glycan anchor biosynthesis, class T 2.21877
HSPA1A heat shock 70kDa protein 1A 2.2161
S100A6 S100 calcium binding protein A6 2.21305
TSPAN4 tetraspanin 4 2.21073
DUSP6 dual specificity phosphatase 6 2.19325
DSG2 desmoglein 2 2.18549
ITGB5 integrin, beta 5 2.18007
PLAAT3 phospholipase A and acyltransferase 3 2.14017
KRT18 keratin 18, type I 2.13434
VAT1 vesicle amine transport 1 2.13243
CUTA cutA divalent cation tolerance homolog (E. coli) 2.1291
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) 2.12202
RFC2 replication factor C (activator 1) 2, 40kDa 2.09916
BCL10 B-cell CLL/lymphoma 10 2.08508
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 2.07582
RNF128 ring finger protein 128, E3 ubiquitin protein ligase 2.06062
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 2.04323
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.03815
FYN FYN proto-oncogene, Src family tyrosine kinase 2.03077
RCN1 reticulocalbin 1, EF-hand calcium binding domain 2.02898
LMCD1 LIM and cysteine-rich domains 1 2.02586
PHLDA2 pleckstrin homology-like domain, family A, member 2 2.02097
PYGB phosphorylase, glycogen; brain 2.00085

decreased expression

Symbol Name Standardized Value
APOA2 apolipoprotein A-II -6.32356
APOH apolipoprotein H (beta-2-glycoprotein I) -5.10935
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.76985
PECR peroxisomal trans-2-enoyl-CoA reductase -4.13852
PROM1 prominin 1 -3.79742
PGM1 phosphoglucomutase 1 -3.52343
TRIB3 tribbles pseudokinase 3 -3.32804
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.21048
TF transferrin -2.99655
C5 complement component 5 -2.92769
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -2.88256
MAT1A methionine adenosyltransferase I, alpha -2.86971
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.86366
MTTP microsomal triglyceride transfer protein -2.76672
HADH hydroxyacyl-CoA dehydrogenase -2.74553
ISOC1 isochorismatase domain containing 1 -2.73724
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) -2.72423
CA5A carbonic anhydrase VA, mitochondrial -2.66622
SLC17A2 solute carrier family 17, member 2 -2.65596
ADH6 alcohol dehydrogenase 6 (class V) -2.63343
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.61717
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.61311
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.58149
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 -2.57971
VAV3 vav 3 guanine nucleotide exchange factor -2.56759
PCID2 PCI domain containing 2 -2.53565
SOAT2 sterol O-acyltransferase 2 -2.53428
APOM apolipoprotein M -2.50488
LIAS lipoic acid synthetase -2.50024
ALDOC aldolase C, fructose-bisphosphate -2.49777
HEATR1 HEAT repeat containing 1 -2.47938
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -2.45858
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 -2.44872
SCD stearoyl-CoA desaturase (delta-9-desaturase) -2.44514
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 -2.44279
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 -2.44272
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -2.43507
C8A complement component 8, alpha polypeptide -2.43244
C4BPA complement component 4 binding protein, alpha -2.42404
NHEJ1 nonhomologous end-joining factor 1 -2.42295
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit -2.41888
MVD mevalonate (diphospho) decarboxylase -2.41404
AHSG alpha-2-HS-glycoprotein -2.40892
CPB2 carboxypeptidase B2 (plasma) -2.4088
CBX4 chromobox homolog 4 -2.39769
NFIL3 nuclear factor, interleukin 3 regulated -2.39206
BICRA BRD4 interacting chromatin remodeling complex associated protein -2.38546
PYGL phosphorylase, glycogen, liver -2.37644
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.33312
SLC2A4RG SLC2A4 regulator -2.32537
APOC3 apolipoprotein C-III -2.32235
GDF7 growth differentiation factor 7 -2.31747
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 -2.29749
S100G S100 calcium binding protein G -2.29587
ZBTB39 zinc finger and BTB domain containing 39 -2.28618
MATK megakaryocyte-associated tyrosine kinase -2.28256
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.25712
MSMO1 methylsterol monooxygenase 1 -2.25336
MCM9 minichromosome maintenance complex component 9 -2.25078
PAH phenylalanine hydroxylase -2.24694
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 -2.24693
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.237
CES1 carboxylesterase 1 -2.21535
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -2.21192
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 -2.19678
MBD5 methyl-CpG binding domain protein 5 -2.19361
CCL16 chemokine (C-C motif) ligand 16 -2.19167
EYA3 EYA transcriptional coactivator and phosphatase 3 -2.18537
CUL4A cullin 4A -2.16988
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 -2.16837
MVK mevalonate kinase -2.16253
APOA1 apolipoprotein A-I -2.16177
TFRC transferrin receptor -2.16116
HPR haptoglobin-related protein -2.15718
AMBP alpha-1-microglobulin/bikunin precursor -2.15601
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 -2.14736
HSPB6 heat shock protein, alpha-crystallin-related, B6 -2.14648
C8B complement component 8, beta polypeptide -2.1462
CFHR3 complement factor H-related 3 -2.14191
SYTL3 synaptotagmin-like 3 -2.14023
NFE2L2 nuclear factor, erythroid 2-like 2 -2.13839
FBXL12 F-box and leucine-rich repeat protein 12 -2.13547
MIS18A MIS18 kinetochore protein A -2.1286
ZNF280B zinc finger protein 280B -2.1258
SLC30A10 solute carrier family 30, member 10 -2.10672
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.10596
NR1I3 nuclear receptor subfamily 1, group I, member 3 -2.09819
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -2.09657
TACR2 tachykinin receptor 2 -2.09154
PURA purine-rich element binding protein A -2.08992
ASGR1 asialoglycoprotein receptor 1 -2.08856
FAM117A family with sequence similarity 117, member A -2.08149
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 -2.06434
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -2.06419
GRID1 glutamate receptor, ionotropic, delta 1 -2.0634
SMAD5 SMAD family member 5 -2.06128
TMEM39A transmembrane protein 39A -2.05742
ARID3B AT rich interactive domain 3B (BRIGHT-like) -2.05579
NPY5R neuropeptide Y receptor Y5 -2.05479
GLTP glycolipid transfer protein -2.05121
RUNX3 runt-related transcription factor 3 -2.05028
RIDA reactive intermediate imine deaminase A homolog -2.04921
MBNL3 muscleblind-like splicing regulator 3 -2.04892
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) -2.04779
SQLE squalene epoxidase -2.04751
AUNIP aurora kinase A and ninein interacting protein -2.04276
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -2.04215
FABP1 fatty acid binding protein 1, liver -2.04203
PANK3 pantothenate kinase 3 -2.03876
ZBTB44 zinc finger and BTB domain containing 44 -2.0323
SDK2 sidekick cell adhesion molecule 2 -2.03144
FGL1 fibrinogen-like 1 -2.03076
APOB apolipoprotein B -2.02997
TRAPPC13 trafficking protein particle complex 13 -2.02725
OLFM1 olfactomedin 1 -2.02167
PIPOX pipecolic acid oxidase -2.02135
ZNF571 zinc finger protein 571 -2.0195
OIP5 Opa interacting protein 5 -2.0162
PNPLA3 patatin-like phospholipase domain containing 3 -2.01368
MEP1A meprin A, alpha (PABA peptide hydrolase) -2.01086
ACOT2 acyl-CoA thioesterase 2 -2.01036
NANOS2 nanos homolog 2 (Drosophila) -2.00872
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.00493
FADS2 fatty acid desaturase 2 -2.00414