CRCGN015_HEPG2_48H:N13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cobalt sulfate heptahydrate 100.3 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

152 genes differentially expressed following the CRCGN015_HEPG2_48H:N13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 9.04323
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 8.32577
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 6.23382
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 5.77109
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 5.15348
KDM3A lysine (K)-specific demethylase 3A 4.71956
INSIG2 insulin induced gene 2 3.85216
DDIT4 DNA-damage-inducible transcript 4 3.64966
PGK1 phosphoglycerate kinase 1 3.57454
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.36201
ENO2 enolase 2 (gamma, neuronal) 3.3069
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 3.26054
EGLN3 egl-9 family hypoxia-inducible factor 3 3.14776
HILPDA hypoxia inducible lipid droplet-associated 3.00696
ALDOC aldolase C, fructose-bisphosphate 2.92028
NFE2L1 nuclear factor, erythroid 2-like 1 2.91377
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.84783
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 2.75902
FHL2 four and a half LIM domains 2 2.70902
PFKP phosphofructokinase, platelet 2.6959
ANKZF1 ankyrin repeat and zinc finger domain containing 1 2.6593
LMBRD1 LMBR1 domain containing 1 2.58728
TNS3 tensin 3 2.57634
EFNA3 ephrin-A3 2.53939
CA9 carbonic anhydrase IX 2.51262
WDR7 WD repeat domain 7 2.50162
GBE1 glucan (1,4-alpha-), branching enzyme 1 2.46549
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 2.4615
TMEM45A transmembrane protein 45A 2.45526
GRAMD2B GRAM domain containing 2B 2.41407
SERINC1 serine incorporator 1 2.40638
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.39886
TNIP1 TNFAIP3 interacting protein 1 2.38782
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 2.38718
LOX lysyl oxidase 2.38538
PTPRR protein tyrosine phosphatase, receptor type, R 2.38025
EIF4A2 eukaryotic translation initiation factor 4A2 2.33301
GPR19 G protein-coupled receptor 19 2.33187
TPI1 triosephosphate isomerase 1 2.30418
ADM adrenomedullin 2.28076
NDRG1 N-myc downstream regulated 1 2.28014
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 2.26425
RIOK3 RIO kinase 3 2.25751
TMEM47 transmembrane protein 47 2.25581
PTTG1IP pituitary tumor-transforming 1 interacting protein 2.22948
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 2.22511
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 2.22306
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 2.21073
VLDLR very low density lipoprotein receptor 2.19711
BLCAP bladder cancer associated protein 2.17714
RNF113A ring finger protein 113A 2.15507
BHLHE40 basic helix-loop-helix family, member e40 2.14457
C5 complement component 5 2.14286
CP ceruloplasmin (ferroxidase) 2.13375
UBQLN2 ubiquilin 2 2.12843
YEATS2 YEATS domain containing 2 2.12172
MXI1 MAX interactor 1, dimerization protein 2.10605
FAM114A1 family with sequence similarity 114, member A1 2.10299
ZW10 zw10 kinetochore protein 2.10173
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.08601
RALGDS ral guanine nucleotide dissociation stimulator 2.0776
ANG angiogenin, ribonuclease, RNase A family, 5 2.07032
RRAGA Ras-related GTP binding A 2.06951
FAM162A family with sequence similarity 162, member A 2.05544
TFEC transcription factor EC 2.05496
CDK5RAP3 CDK5 regulatory subunit associated protein 3 2.0458
SLC39A14 solute carrier family 39 (zinc transporter), member 14 2.04479
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2.02739
BIRC3 baculoviral IAP repeat containing 3 2.01767
FAT1 FAT atypical cadherin 1 2.01347
DDB2 damage-specific DNA binding protein 2, 48kDa 2.00499

decreased expression

Symbol Name Standardized Value
UGDH UDP-glucose 6-dehydrogenase -6.08232
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.84858
TM9SF3 transmembrane 9 superfamily member 3 -3.40648
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -3.22477
CENPE centromere protein E, 312kDa -2.92425
CCDC86 coiled-coil domain containing 86 -2.91462
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) -2.89709
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.84549
MAPK13 mitogen-activated protein kinase 13 -2.79101
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.78996
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.76315
BORCS8 BLOC-1 related complex subunit 8 -2.75872
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.73432
UBTD1 ubiquitin domain containing 1 -2.73152
IPO4 importin 4 -2.71159
MVD mevalonate (diphospho) decarboxylase -2.7031
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.65472
ISOC1 isochorismatase domain containing 1 -2.63279
RUVBL2 RuvB-like AAA ATPase 2 -2.58677
POLR3B polymerase (RNA) III (DNA directed) polypeptide B -2.56158
PDCD11 programmed cell death 11 -2.54415
MANF mesencephalic astrocyte-derived neurotrophic factor -2.53469
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -2.52229
RIOX1 ribosomal oxygenase 1 -2.49906
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.49614
ELOVL6 ELOVL fatty acid elongase 6 -2.46947
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 -2.46815
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast) -2.43332
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) -2.43154
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.38944
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast) -2.3762
ATAD3A ATPase family, AAA domain containing 3A -2.349
RHOB ras homolog family member B -2.34342
POLL polymerase (DNA directed), lambda -2.31716
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.29426
LETM1 leucine zipper-EF-hand containing transmembrane protein 1 -2.27378
WDR4 WD repeat domain 4 -2.26721
DBF4 DBF4 zinc finger -2.26521
BRMS1L breast cancer metastasis-suppressor 1-like -2.26071
MTERF3 mitochondrial transcription termination factor 3 -2.25613
SDF2L1 stromal cell-derived factor 2-like 1 -2.25559
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -2.25084
WDR77 WD repeat domain 77 -2.24785
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.24056
LCMT2 leucine carboxyl methyltransferase 2 -2.22776
MRPL12 mitochondrial ribosomal protein L12 -2.20203
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -2.19623
WDR46 WD repeat domain 46 -2.19369
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) -2.1908
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.19061
CRH corticotropin releasing hormone -2.17543
RUVBL1 RuvB-like AAA ATPase 1 -2.15895
UBE2S ubiquitin-conjugating enzyme E2S -2.14748
MVK mevalonate kinase -2.14332
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) -2.14171
IGFALS insulin-like growth factor binding protein, acid labile subunit -2.13977
SETD1A SET domain containing 1A -2.1396
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa -2.13926
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) -2.13893
RTL10 retrotransposon Gag like 10 -2.1359
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites -2.13154
LBHD1 LBH domain containing 1 -2.13031
CHUK conserved helix-loop-helix ubiquitous kinase -2.11804
EML3 echinoderm microtubule associated protein like 3 -2.11279
RRP1B ribosomal RNA processing 1B -2.10918
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 -2.09919
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -2.09382
DNAAF2 dynein, axonemal, assembly factor 2 -2.09334
NSD1 nuclear receptor binding SET domain protein 1 -2.09058
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -2.08796
SOAT2 sterol O-acyltransferase 2 -2.08294
NSUN3 NOP2/Sun domain family, member 3 -2.07727
MRPL42 mitochondrial ribosomal protein L42 -2.0762
PBK PDZ binding kinase -2.0624
PPP2R5D protein phosphatase 2, regulatory subunit B', delta -2.05568
MCM10 minichromosome maintenance complex component 10 -2.04625
QDPR quinoid dihydropteridine reductase -2.03748
VCX3A variable charge, X-linked 3A -2.03691
BMPR1A bone morphogenetic protein receptor, type IA -2.0182
RIN1 Ras and Rab interactor 1 -2.01053
EVX1 even-skipped homeobox 1 -2.008