CRCGN015_HEPG2_48H:N16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-epoxybutane 97.3 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

23 genes differentially expressed following the CRCGN015_HEPG2_48H:N16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 4.21587
PRKCQ protein kinase C, theta 4.05135
UBQLN2 ubiquilin 2 3.21963
SMIM40 small integral membrane protein 40 2.83635
MOK MOK protein kinase 2.54172
TNIP1 TNFAIP3 interacting protein 1 2.4146
USP11 ubiquitin specific peptidase 11 2.412
GTPBP8 GTP-binding protein 8 (putative) 2.24519
CCKBR cholecystokinin B receptor 2.23069
GAPDH glyceraldehyde-3-phosphate dehydrogenase 2.13671
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 2.04863
ZNF281 zinc finger protein 281 2.04036
TXNL4B thioredoxin-like 4B 2.03186
RPL21 ribosomal protein L21 2.0047

decreased expression

Symbol Name Standardized Value
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -5.67783
TM9SF3 transmembrane 9 superfamily member 3 -4.48982
MT1X metallothionein 1X -3.34498
NCK1 NCK adaptor protein 1 -3.11823
CCNB1 cyclin B1 -3.09382
CDC20 cell division cycle 20 -2.96998
LYPLA1 lysophospholipase I -2.8572
SNX7 sorting nexin 7 -2.43739
PROS1 protein S (alpha) -2.41986