CRCGN015_HEPG2_48H:N18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-epoxybutane 10.81 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN015_HEPG2_48H:N18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 4.06106
ABHD6 abhydrolase domain containing 6 3.41277
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.91512
PLSCR3 phospholipid scramblase 3 2.69994
MINDY1 MINDY lysine 48 deubiquitinase 1 2.63633
FPGS folylpolyglutamate synthase 2.57826
KLHL21 kelch-like family member 21 2.54297
TATDN2 TatD DNase domain containing 2 2.49861
MYL9 myosin, light chain 9, regulatory 2.39062
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.26831
KAT6A K(lysine) acetyltransferase 6A 2.08758
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.05942
USP18 ubiquitin specific peptidase 18 2.05354
ZNF134 zinc finger protein 134 2.01777

decreased expression

Symbol Name Standardized Value
SNX7 sorting nexin 7 -3.63887
PCNA proliferating cell nuclear antigen -3.49429
EIF5 eukaryotic translation initiation factor 5 -3.24063
VAT1 vesicle amine transport 1 -2.77633
MRPS16 mitochondrial ribosomal protein S16 -2.77244
HEATR1 HEAT repeat containing 1 -2.69687
MT1X metallothionein 1X -2.57356
TSPAN4 tetraspanin 4 -2.48319
MKKS McKusick-Kaufman syndrome -2.45136
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.32554
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.28743
FASTKD5 FAST kinase domains 5 -2.28486
PANK2 pantothenate kinase 2 -2.28132
DDRGK1 DDRGK domain containing 1 -2.1644
NSFL1C NSFL1 (p97) cofactor (p47) -2.03912
TMEM230 transmembrane protein 230 -2.02061
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.01378