CRCGN015_HEPG2_48H:O06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN015_HEPG2_48H:O06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KDM5A lysine (K)-specific demethylase 5A 5.38143
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5.12628
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 4.74011
CHN1 chimerin 1 4.15832
PLSCR3 phospholipid scramblase 3 3.52736
KIF5C kinesin family member 5C 2.63826
CRLF3 cytokine receptor-like factor 3 2.55344
PAGE4 P antigen family, member 4 (prostate associated) 2.41509
NDNF neuron-derived neurotrophic factor 2.34881
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2.3312
MDFIC MyoD family inhibitor domain containing 2.28645
DHDDS dehydrodolichyl diphosphate synthase 2.27731
LEP leptin 2.2643
BHMT2 betaine--homocysteine S-methyltransferase 2 2.24398
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.21108
KIF3A kinesin family member 3A 2.17087
ANGPT1 angiopoietin 1 2.11876
TATDN2 TatD DNase domain containing 2 2.1059
CXCR4 chemokine (C-X-C motif) receptor 4 2.08482
COPZ2 coatomer protein complex, subunit zeta 2 2.08072
SLC39A7 solute carrier family 39 (zinc transporter), member 7 2.0696
NEFH neurofilament, heavy polypeptide 2.05294
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 2.05048
DCAF16 DDB1 and CUL4 associated factor 16 2.03997

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.85707
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.50781
VAT1 vesicle amine transport 1 -3.39366
ZBTB35 zinc finger and BTB domain containing 35 -3.24887
PLIN2 perilipin 2 -2.80788
NGRN neugrin, neurite outgrowth associated -2.75453
TFRC transferrin receptor -2.69456
KATNBL1 katanin p80 subunit B-like 1 -2.48181
ZNF263 zinc finger protein 263 -2.41429
SNX7 sorting nexin 7 -2.21547
TUBG2 tubulin, gamma 2 -2.07933
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) -2.07389
DUOX2 dual oxidase 2 -2.02772
MTO1 mitochondrial tRNA translation optimization 1 -2.02444