CRCGN015_HEPG2_48H:O07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description indometacin 99.61 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

18 genes differentially expressed following the CRCGN015_HEPG2_48H:O07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 3.50804
FPGS folylpolyglutamate synthase 3.45959
TRIB3 tribbles pseudokinase 3 2.66197
PMM2 phosphomannomutase 2 2.63161
ECH1 enoyl CoA hydratase 1, peroxisomal 2.48758
FDFT1 farnesyl-diphosphate farnesyltransferase 1 2.4737
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.35239
BAD BCL2-associated agonist of cell death 2.19198
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.12967
FADS2 fatty acid desaturase 2 2.04912
PLSCR3 phospholipid scramblase 3 2.01807

decreased expression

Symbol Name Standardized Value
EIF5 eukaryotic translation initiation factor 5 -4.47361
JMJD6 jumonji domain containing 6 -3.95833
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.44287
SAP30BP SAP30 binding protein -2.33171
RSRC2 arginine/serine-rich coiled-coil 2 -2.15184
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -2.13914
CYTIP cytohesin 1 interacting protein -2.05719