CRCGN015_HEPG2_48H:O08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description indometacin 33.2 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN015_HEPG2_48H:O08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCR4 chemokine (C-X-C motif) receptor 4 5.32028
SNX11 sorting nexin 11 4.39101
TNIP1 TNFAIP3 interacting protein 1 4.3753
PLEKHJ1 pleckstrin homology domain containing, family J member 1 4.08506
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.78214
METRN meteorin, glial cell differentiation regulator 3.42532
CRTAP cartilage associated protein 3.32032
TIMP2 TIMP metallopeptidase inhibitor 2 3.00387
EAPP E2F-associated phosphoprotein 2.96338
CBX1 chromobox homolog 1 2.80136
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.55405
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.39873
TRAF1 TNF receptor-associated factor 1 2.24287
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 2.16915
NFE2L1 nuclear factor, erythroid 2-like 1 2.16114
FSTL3 follistatin-like 3 (secreted glycoprotein) 2.09417
IRF8 interferon regulatory factor 8 2.06235
CD83 CD83 molecule 2.00476

decreased expression

Symbol Name Standardized Value
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -5.03183
PECR peroxisomal trans-2-enoyl-CoA reductase -4.72413
CCNB1 cyclin B1 -4.11982
ISOC1 isochorismatase domain containing 1 -4.07192
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.88168
FOXJ3 forkhead box J3 -3.58785
MCM3 minichromosome maintenance complex component 3 -3.16538
PROM1 prominin 1 -2.49452
S100A11 S100 calcium binding protein A11 -2.25486
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa -2.22224
CALHM2 calcium homeostasis modulator 2 -2.17218
LOC124907782 dual specificity protein phosphatase 22 -2.13267
PAMR1 peptidase domain containing associated with muscle regeneration 1 -2.04335