CRCGN015_HEPG2_48H:O16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5-nitroacenaphthene 98.4 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

27 genes differentially expressed following the CRCGN015_HEPG2_48H:O16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LOC122526780 uncharacterized LOC122526780 3.29774
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 3.27183
COQ8A coenzyme Q8A 3.07684
PRR15L proline rich 15-like 2.93777
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.65094
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.51097
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.4198
STIMATE STIM activating enhancer 2.40002
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 2.38336
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.30163
DDB2 damage-specific DNA binding protein 2, 48kDa 2.21264
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.09226
C5 complement component 5 2.04177
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.01787
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.00293

decreased expression

Symbol Name Standardized Value
PLIN2 perilipin 2 -3.79766
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 -3.56288
MT1X metallothionein 1X -3.03319
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.83552
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.72751
MRPS22 mitochondrial ribosomal protein S22 -2.36439
VAT1 vesicle amine transport 1 -2.3483
PRL prolactin -2.23463
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 -2.20781
ZMIZ1 zinc finger, MIZ-type containing 1 -2.17688
NUCB2 nucleobindin 2 -2.13493
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.06024