CRCGN015_HEPG2_48H:P03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acedapsone 10.92 um perturbation at 48 h in HEPG2 (Carcinogenome)
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Genes

248 genes differentially expressed following the CRCGN015_HEPG2_48H:P03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.13397
MAMLD1 mastermind-like domain containing 1 5.08445
CD8A CD8a molecule 4.4695
BAD BCL2-associated agonist of cell death 4.26443
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.14286
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.6894
AARS1 alanyl-tRNA synthetase 1 3.48729
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 3.41346
IL2RB interleukin 2 receptor, beta 3.35788
NUCB2 nucleobindin 2 3.3244
MED24 mediator complex subunit 24 3.29053
CCDC86 coiled-coil domain containing 86 3.23332
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 3.23313
RAB31 RAB31, member RAS oncogene family 3.12789
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 3.03516
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 3.02406
CRTAM cytotoxic and regulatory T cell molecule 2.92519
CASC3 cancer susceptibility candidate 3 2.88964
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 2.88746
CORO1A coronin, actin binding protein, 1A 2.83218
CLSTN3 calsyntenin 3 2.80244
NCKIPSD NCK interacting protein with SH3 domain 2.79148
RHEB Ras homolog enriched in brain 2.7568
MARK3 MAP/microtubule affinity-regulating kinase 3 2.75478
DENND4B DENN/MADD domain containing 4B 2.68895
IL5 interleukin 5 2.68851
CLPTM1 cleft lip and palate associated transmembrane protein 1 2.65349
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 2.64709
CCL1 chemokine (C-C motif) ligand 1 2.60024
IL26 interleukin 26 2.59636
RMDN3 regulator of microtubule dynamics 3 2.58419
USP18 ubiquitin specific peptidase 18 2.5779
ANO2 anoctamin 2, calcium activated chloride channel 2.55497
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.53751
IKZF3 IKAROS family zinc finger 3 (Aiolos) 2.49241
ETV7 ets variant 7 2.48854
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.45724
ITK IL2-inducible T-cell kinase 2.44261
E2F5 E2F transcription factor 5, p130-binding 2.4356
SYMPK symplekin 2.43054
GPR171 G protein-coupled receptor 171 2.42701
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 2.42349
FASLG Fas ligand (TNF superfamily, member 6) 2.4124
UBE2M ubiquitin-conjugating enzyme E2M 2.40851
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2.39841
CUL1 cullin 1 2.383
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 2.35826
TLK2 tousled-like kinase 2 2.35188
ANKRD36C ankyrin repeat domain 36C 2.34622
GCM1 glial cells missing homolog 1 (Drosophila) 2.34388
DNM2 dynamin 2 2.34213
NYNRIN NYN domain and retroviral integrase containing 2.34147
RASIP1 Ras interacting protein 1 2.3359
GSK3A glycogen synthase kinase 3 alpha 2.31731
ITGB7 integrin, beta 7 2.31488
KRT86 keratin 86, type II 2.31357
IL12A interleukin 12A 2.30859
GPHRA golgi pH regulator A 2.2922
ATP8B4 ATPase, class I, type 8B, member 4 2.27378
MAP2K2 mitogen-activated protein kinase kinase 2 2.26899
CLEC2D C-type lectin domain family 2, member D 2.2536
CD53 CD53 molecule 2.25323
DENND4A DENN/MADD domain containing 4A 2.24422
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 2.23649
HELZ helicase with zinc finger 2.22535
BCAS4 breast carcinoma amplified sequence 4 2.21235
PSKH1 protein serine kinase H1 2.21152
CXCR3 chemokine (C-X-C motif) receptor 3 2.19832
PPP5C protein phosphatase 5, catalytic subunit 2.1976
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.18988
SLC4A2 solute carrier family 4 (anion exchanger), member 2 2.18801
MED15 mediator complex subunit 15 2.17689
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 2.17353
EZR ezrin 2.17254
CHPF chondroitin polymerizing factor 2.17094
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 2.17007
ATP5F1B ATP synthase F1 subunit beta 2.16565
MTSS2 MTSS I-BAR domain containing 2 2.16559
PSD4 pleckstrin and Sec7 domain containing 4 2.16177
BTBD2 BTB (POZ) domain containing 2 2.15854
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.15368
MRPL4 mitochondrial ribosomal protein L4 2.14724
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 2.14694
NUP155 nucleoporin 155kDa 2.14508
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 2.14439
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.14386
SLCO4C1 solute carrier organic anion transporter family, member 4C1 2.14029
XCL1 chemokine (C motif) ligand 1 2.13992
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 2.13812
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 2.13605
BBC3 BCL2 binding component 3 2.13281
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 2.13278
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I 2.1325
LSP1 lymphocyte-specific protein 1 2.12907
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 2.12535
TRAF4 TNF receptor-associated factor 4 2.12038
IL13 interleukin 13 2.11723
FAM3C family with sequence similarity 3, member C 2.11121
SRD5A3 steroid 5 alpha-reductase 3 2.10579
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2.10572
INO80B INO80 complex subunit B 2.09947
NUP205 nucleoporin 205kDa 2.09946
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c 2.09616
FKBP8 FK506 binding protein 8, 38kDa 2.09327
TTC13 tetratricopeptide repeat domain 13 2.09168
ADCY7 adenylate cyclase 7 2.08685
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 2.07899
CTF1 cardiotrophin 1 2.07057
MELK maternal embryonic leucine zipper kinase 2.06801
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 2.06787
IL9 interleukin 9 2.06685
LGSN lengsin, lens protein with glutamine synthetase domain 2.0666
PSG5 pregnancy specific beta-1-glycoprotein 5 2.06422
STAT2 signal transducer and activator of transcription 2, 113kDa 2.06151
SNAI1 snail family zinc finger 1 2.05889
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 2.05773
RPL29 ribosomal protein L29 2.05319
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma 2.05316
NR5A2 nuclear receptor subfamily 5, group A, member 2 2.05254
NCR3 natural cytotoxicity triggering receptor 3 2.04787
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 2.04578
HLA-A major histocompatibility complex, class I, A 2.04534
MEST mesoderm specific transcript 2.04509
TFB2M transcription factor B2, mitochondrial 2.04472
PDCD6 programmed cell death 6 2.04334
STAP1 signal transducing adaptor family member 1 2.03741
DUSP14 dual specificity phosphatase 14 2.03657
TMEM132A transmembrane protein 132A 2.03543
SPTBN4 spectrin, beta, non-erythrocytic 4 2.02841
ESRRA estrogen-related receptor alpha 2.02611
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 2.02525
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.02416
SNCAIP synuclein, alpha interacting protein 2.02136
IRF1 interferon regulatory factor 1 2.02015
SSTR2 somatostatin receptor 2 2.02009
GALK1 galactokinase 1 2.01736
GSTA1 glutathione S-transferase alpha 1 2.01667
EHMT1 euchromatic histone-lysine N-methyltransferase 1 2.0164
FMO5 flavin containing monooxygenase 5 2.01366
H2BC17 H2B clustered histone 17 2.01273
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 2.00932
RCC1L RCC1 like 2.0092
NRSN2 neurensin 2 2.00889
GCDH glutaryl-CoA dehydrogenase 2.00817
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.00758
REL v-rel avian reticuloendotheliosis viral oncogene homolog 2.0057
GP5 glycoprotein V (platelet) 2.00032

decreased expression

Symbol Name Standardized Value
PROM1 prominin 1 -6.01579
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -5.793
NCK1 NCK adaptor protein 1 -5.28364
ACOT9 acyl-CoA thioesterase 9 -4.99732
ANXA5 annexin A5 -3.70207
HADH hydroxyacyl-CoA dehydrogenase -3.61341
S100P S100 calcium binding protein P -3.50841
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.4874
VPS33B vacuolar protein sorting 33 homolog B (yeast) -3.41515
LYRM1 LYR motif containing 1 -3.39822
KIFBP kinesin family binding protein -3.37148
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -3.34103
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -3.25544
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa -3.25029
DTD1 D-tyrosyl-tRNA deacylase 1 -3.23487
NCK2 NCK adaptor protein 2 -3.2012
NT5C2 5'-nucleotidase, cytosolic II -3.13987
TBPL1 TBP-like 1 -3.12135
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -3.09516
THBS4 thrombospondin 4 -3.03205
CCNH cyclin H -2.92264
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.90636
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 -2.90136
UBE4A ubiquitination factor E4A -2.89837
BMP4 bone morphogenetic protein 4 -2.77822
RWDD3 RWD domain containing 3 -2.71823
PDCL3 phosducin-like 3 -2.70504
BTK Bruton agammaglobulinemia tyrosine kinase -2.68427
ANXA7 annexin A7 -2.66896
MED7 mediator complex subunit 7 -2.6512
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.62893
ZNF706 zinc finger protein 706 -2.61935
MORF4L1 mortality factor 4 like 1 -2.56083
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.54206
BMP6 bone morphogenetic protein 6 -2.54181
TXNDC9 thioredoxin domain containing 9 -2.52578
PTBP2 polypyrimidine tract binding protein 2 -2.49229
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -2.48963
GNG5 guanine nucleotide binding protein (G protein), gamma 5 -2.47703
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.47176
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.43586
RHOB ras homolog family member B -2.40359
CFP complement factor properdin -2.40013
NOSIP nitric oxide synthase interacting protein -2.3774
JAK1 Janus kinase 1 -2.3682
GGT5 gamma-glutamyltransferase 5 -2.3558
THAP1 THAP domain containing, apoptosis associated protein 1 -2.34916
PRNP prion protein -2.34615
PRSS3 protease, serine, 3 -2.33592
PNPLA4 patatin-like phospholipase domain containing 4 -2.31669
MOSPD2 motile sperm domain containing 2 -2.29525
CAB39 calcium binding protein 39 -2.28655
ACVR1 activin A receptor, type I -2.28522
SCML2 sex comb on midleg-like 2 (Drosophila) -2.28483
TTC12 tetratricopeptide repeat domain 12 -2.2585
PCNP PEST proteolytic signal containing nuclear protein -2.25726
MUTYH mutY homolog -2.25341
ZC3H7A zinc finger CCCH-type containing 7A -2.24166
MED8 mediator complex subunit 8 -2.22409
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B -2.22372
GCC2 GRIP and coiled-coil domain containing 2 -2.21962
APOO apolipoprotein O -2.21855
AOPEP aminopeptidase O (putative) -2.20241
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.20077
PIR pirin (iron-binding nuclear protein) -2.19755
CRYZ crystallin, zeta (quinone reductase) -2.19514
SMNDC1 survival motor neuron domain containing 1 -2.17896
FAR2 fatty acyl CoA reductase 2 -2.17744
ZBTB16 zinc finger and BTB domain containing 16 -2.17611
LOC127933115 uncharacterized LOC127933115 -2.17188
DGUOK deoxyguanosine kinase -2.14636
SCYL3 SCY1-like 3 (S. cerevisiae) -2.13977
PTK6 protein tyrosine kinase 6 -2.12143
CCP110 centriolar coiled coil protein 110kDa -2.11817
GMPS guanine monphosphate synthase -2.11148
RAP1GAP2 RAP1 GTPase activating protein 2 -2.10958
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.1033
CRYBG3 beta-gamma crystallin domain containing 3 -2.10239
RBMX2 RNA binding motif protein, X-linked 2 -2.1015
TXNRD1 thioredoxin reductase 1 -2.09822
SEC11A SEC11 homolog A (S. cerevisiae) -2.09142
SNRPG small nuclear ribonucleoprotein polypeptide G -2.0907
EXOSC8 exosome component 8 -2.08916
ZFYVE16 zinc finger, FYVE domain containing 16 -2.07158
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.06516
GLB1L2 galactosidase, beta 1-like 2 -2.0579
ANO1 anoctamin 1, calcium activated chloride channel -2.05665
CIB1 calcium and integrin binding 1 (calmyrin) -2.05529
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -2.054
CETN3 centrin, EF-hand protein, 3 -2.04588
SLC31A2 solute carrier family 31 (copper transporter), member 2 -2.02986
GIN1 gypsy retrotransposon integrase 1 -2.02979
FKBP5 FK506 binding protein 5 -2.02919
TOR1B torsin family 1, member B (torsin B) -2.02788
GPR143 G protein-coupled receptor 143 -2.02586
TM9SF3 transmembrane 9 superfamily member 3 -2.02267
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -2.02134
CSNK1G3 casein kinase 1, gamma 3 -2.01843
BBIP1 BBSome interacting protein 1 -2.01772
WASHC3 WASH complex subunit 3 -2.01271
RETN resistin -2.00954